1NA6
 
 | | Crystal structure of restriction endonuclease EcoRII mutant R88A | | 分子名称: | Restriction endonuclease EcoRII | | 著者 | Zhou, X.E, Wang, Y, Reuter, M, Mucke, M, Kruger, D.H, Meehan, E.J, Chen, L. | | 登録日 | 2002-11-26 | | 公開日 | 2003-12-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of type IIE restriction endonuclease EcoRII reveals an autoinhibition mechanism by a novel effector-binding fold.
J.Mol.Biol., 335, 2004
|
|
5FIQ
 | | Exonuclease domain-containing 1 (Exd1) in the native conformation | | 分子名称: | EXD1 | | 著者 | Yang, Z, Chen, K.M, Pandey, R.R, Homolka, D, Reuter, M, Rodino Janeiro, B.K, Sachidanandam, R, Fauvarque, M.O, McCarthy, A.A, Pillai, R.S. | | 登録日 | 2015-10-01 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Piwi Slicing and Exd1 Drive Biogenesis of Nuclear Pirnas from Cytosolic Targets of the Mouse Pirna Pathway
Mol.Cell, 61, 2016
|
|
5FIS
 | | Exonuclease domain-containing 1 (Exd1) in the Gd bound conformation | | 分子名称: | EXD1, GADOLINIUM ATOM | | 著者 | Yang, Z, Chen, K.M, Pandey, R.R, Homolka, D, Reuter, M, Rodino Janeiro, B.K, Sachidanandam, R, Fauvarque, M.O, McCarthy, A.A, Pillai, R.S. | | 登録日 | 2015-10-02 | | 公開日 | 2015-12-23 | | 最終更新日 | 2016-01-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Piwi Slicing and Exd1 Drive Biogenesis of Nuclear Pirnas from Cytosolic Targets of the Mouse Pirna Pathway
Mol.Cell, 61, 2016
|
|
5O8M
 | |
2XFM
 | | Complex structure of the MIWI Paz domain bound to methylated single stranded RNA | | 分子名称: | 5'-R(*AP*CP*CP*GP*AP*CP*UP*(OMU)P)-3', PIWI-LIKE PROTEIN 1 | | 著者 | Simon, B, Kirkpatrick, J.P, Eckhardt, S, Sehr, P, Andrade-Navarro, M.A, Pillai, R.S, Carlomagno, T. | | 登録日 | 2010-05-27 | | 公開日 | 2011-01-26 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recognition of 2'-O-Methylated 3'-End of Pirna by the Paz Domain of a Piwi Protein.
Structure, 19, 2011
|
|
2A1S
 | |
2A1R
 | | Crystal structure of PARN nuclease domain | | 分子名称: | 5'-R(*AP*AP*A)-3', Poly(A)-specific ribonuclease PARN | | 著者 | Wu, M, Song, H. | | 登録日 | 2005-06-21 | | 公開日 | 2005-12-20 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural insight into poly(A) binding and catalytic mechanism of human PARN
Embo J., 24, 2005
|
|
3HQF
 | | Crystal structure of restriction endonuclease EcoRII N-terminal effector-binding domain in complex with cognate DNA | | 分子名称: | 5'-D(*CP*GP*CP*CP*AP*GP*GP*GP*C)-3', 5'-D(*GP*CP*CP*CP*TP*GP*GP*CP*G)-3', Restriction endonuclease | | 著者 | Golovenko, D, Manakova, E, Grazulis, S, Tamulaitiene, G, Siksnys, V. | | 登録日 | 2009-06-06 | | 公開日 | 2009-09-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Structural mechanisms for the 5'-CCWGG sequence recognition by the N- and C-terminal domains of EcoRII.
Nucleic Acids Res., 37, 2009
|
|
3HQG
 | | Crystal structure of restriction endonuclease EcoRII catalytic C-terminal domain in complex with cognate DNA | | 分子名称: | 5'-D(*TP*AP*GP*CP*CP*TP*GP*GP*TP*CP*GP*A)-3', 5'-D(*TP*CP*GP*AP*CP*CP*AP*GP*GP*CP*TP*A)-3', GLYCEROL, ... | | 著者 | Golovenko, D, Manakova, E, Grazulis, S, Tamulaitiene, G, Siksnys, V. | | 登録日 | 2009-06-06 | | 公開日 | 2009-09-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural mechanisms for the 5'-CCWGG sequence recognition by the N- and C-terminal domains of EcoRII.
Nucleic Acids Res., 37, 2009
|
|
4H4A
 | |
4IWD
 | | Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-8033 analog | | 分子名称: | 1-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-N-(pyridin-2-ylmethyl)methanesulfonamide, Hepatocyte growth factor receptor | | 著者 | Soisson, S.M, Northrup, A, Rickert, K, Patel, S, Allison, T. | | 登録日 | 2013-01-23 | | 公開日 | 2013-12-11 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
J.Med.Chem., 56, 2013
|
|
6UXX
 | | PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 1a | | 分子名称: | (5R)-2-amino-5-(4-methoxyphenyl)-3-methyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-yl]-3,5-dihydro-4H-imidazol-4-one, Methylosome protein 50, Protein arginine N-methyltransferase 5 | | 著者 | Palte, R.L, Schneider, S.E. | | 登録日 | 2019-11-08 | | 公開日 | 2020-08-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).
Acs Med.Chem.Lett., 11, 2020
|
|
6UXY
 | | PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 8 | | 分子名称: | (5R)-2-amino-5-(2-cyclohexylethyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one, 1,2-ETHANEDIOL, GLYCEROL, ... | | 著者 | Palte, R.L, Schneider, S.E. | | 登録日 | 2019-11-08 | | 公開日 | 2020-08-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).
Acs Med.Chem.Lett., 11, 2020
|
|
