4LBE
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![BU of 4lbe by Molmil](/molmil-images/mine/4lbe) | Structure of KcsA with R122A mutation | 分子名称: | DIACYL GLYCEROL, Fab heavy chain, Fab light chain, ... | 著者 | Nimigean, C.M, Posson, D.J, McCoy, J.M. | 登録日 | 2013-06-20 | 公開日 | 2013-10-30 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | 主引用文献 | Molecular interactions involved in proton-dependent gating in KcsA potassium channels. J.Gen.Physiol., 142, 2013
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4LCU
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![BU of 4lcu by Molmil](/molmil-images/mine/4lcu) | Structure of KcsA with E118A mutation | 分子名称: | DIACYL GLYCEROL, Fab heavy chain, Fab light chain, ... | 著者 | Nimigean, C.M, Posson, D.J, McCoy, J.M. | 登録日 | 2013-06-23 | 公開日 | 2013-10-30 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.752 Å) | 主引用文献 | Molecular interactions involved in proton-dependent gating in KcsA potassium channels. J.Gen.Physiol., 142, 2013
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6CJT
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6CJU
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6CJQ
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![BU of 6cjq by Molmil](/molmil-images/mine/6cjq) | Structure of the SthK cyclic nucleotide-gated potassium channel | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, SthK cyclic nucleotide-gated potassium channel | 著者 | Nimigean, C.M, Rheinberger, J. | 登録日 | 2018-02-26 | 公開日 | 2018-08-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures. Elife, 7, 2018
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9BC6
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![BU of 9bc6 by Molmil](/molmil-images/mine/9bc6) | HCN1 M305L with propofol | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Kim, E.D, Nimigean, C.M. | 登録日 | 2024-04-07 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632, 2024
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9BC7
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![BU of 9bc7 by Molmil](/molmil-images/mine/9bc7) | HCN1 M305L holo | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Kim, E.D, Nimigean, C.M. | 登録日 | 2024-04-08 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632, 2024
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3GB7
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![BU of 3gb7 by Molmil](/molmil-images/mine/3gb7) | Potassium Channel KcsA-Fab complex in Li+ | 分子名称: | DIACYL GLYCEROL, NICKEL (II) ION, Voltage-gated potassium channel, ... | 著者 | Thompson, A.N, Ilsoo, K, Panosian, T.D, Iverson, T.M, Allen, T.W, Nimigean, C.M. | 登録日 | 2009-02-18 | 公開日 | 2009-11-17 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nat.Struct.Mol.Biol., 16, 2009
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3IGA
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![BU of 3iga by Molmil](/molmil-images/mine/3iga) | Potassium Channel KcsA-Fab complex in Li+ and K+ | 分子名称: | Antibody Fab Fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | 著者 | Thompson, A.N, Ilsoo, K, Panosian, T.D, Iverson, T.M, Allen, T.W, Nimigean, C.M. | 登録日 | 2009-07-27 | 公開日 | 2009-11-17 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nat.Struct.Mol.Biol., 16, 2009
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8DJB
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8DE9
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![BU of 8de9 by Molmil](/molmil-images/mine/8de9) | Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPE mixed micelles | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, POTASSIUM ION, Potassium channel, ... | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | 登録日 | 2022-06-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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8DE8
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![BU of 8de8 by Molmil](/molmil-images/mine/8de8) | Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM/POPA mixed micelles | 分子名称: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, POTASSIUM ION, Potassium channel, ... | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | 登録日 | 2022-06-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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8DE7
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![BU of 8de7 by Molmil](/molmil-images/mine/8de7) | Cryo-EM structure of the zebrafish two pore domain K+ channel TREK1 (K2P2.1) in DDM detergent | 分子名称: | DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, Potassium channel, ... | 著者 | Schmidpeter, P.A.M, Nimigean, C.M, Riegelhaupt, P.M. | 登録日 | 2022-06-20 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1. Nat Commun, 14, 2023
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8FZ7
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![BU of 8fz7 by Molmil](/molmil-images/mine/8fz7) | TpeA bound closed MthK-A88F mutant in nanodisc | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1-(tripentyl-$l^{4}-azanyl)pentane, Calcium-gated potassium channel MthK, ... | 著者 | Agarwal, S, Nimigean, C.M. | 登録日 | 2023-01-27 | 公開日 | 2023-10-11 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Calcium-gated potassium channel blockade via membrane-facing fenestrations. Nat.Chem.Biol., 20, 2024
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3OGC
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![BU of 3ogc by Molmil](/molmil-images/mine/3ogc) | KcsA E71A variant in presence of Na+ | 分子名称: | SODIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ... | 著者 | McCoy, J.G, Nimigean, C.M. | 登録日 | 2010-08-16 | 公開日 | 2011-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Mechanism for selectivity-inactivation coupling in KcsA potassium channels. Proc.Natl.Acad.Sci.USA, 108, 2011
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8UC8
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![BU of 8uc8 by Molmil](/molmil-images/mine/8uc8) | HCN1 nanodisc | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Kim, E.D, Nimigean, C.M. | 登録日 | 2023-09-25 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632, 2024
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8UC7
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![BU of 8uc7 by Molmil](/molmil-images/mine/8uc7) | HCN1 complex with propofol | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Kim, E.D, Nimigean, C.M. | 登録日 | 2023-09-25 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632, 2024
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4HZ3
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![BU of 4hz3 by Molmil](/molmil-images/mine/4hz3) | MthK pore crystallized in presence of TBSb | 分子名称: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | 著者 | Posson, D.J, McCoy, J.G, Nimigean, C.M. | 登録日 | 2012-11-14 | 公開日 | 2012-12-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter. Nat.Struct.Mol.Biol., 20, 2013
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4HYO
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![BU of 4hyo by Molmil](/molmil-images/mine/4hyo) | Crystal Structure of MthK Pore | 分子名称: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | 著者 | Posson, D.J, McCoy, J.G, Nimigean, C.M. | 登録日 | 2012-11-13 | 公開日 | 2012-12-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter. Nat.Struct.Mol.Biol., 20, 2013
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4CHW
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![BU of 4chw by Molmil](/molmil-images/mine/4chw) | The electron crystallography structure of the cAMP-free potassium channel MloK1 | 分子名称: | CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION | 著者 | Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. | 登録日 | 2013-12-04 | 公開日 | 2014-01-15 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (7 Å) | 主引用文献 | Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1. Nat Commun, 5, 2014
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4CHV
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![BU of 4chv by Molmil](/molmil-images/mine/4chv) | The electron crystallography structure of the cAMP-bound potassium channel MloK1 | 分子名称: | CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION | 著者 | Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. | 登録日 | 2013-12-04 | 公開日 | 2014-01-15 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (7 Å) | 主引用文献 | Ligand-Induced Structural Changes in the Cyclic Nucleotide-Modulated Potassium Channel Mlok1 Nat.Commun., 5, 2014
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5BKI
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![BU of 5bki by Molmil](/molmil-images/mine/5bki) | Blocker-free closed MthK channel in nanodisc | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CADMIUM ION, Calcium-gated potassium channel MthK, ... | 著者 | Fan, C, Nimigean, C.M. | 登録日 | 2021-03-19 | 公開日 | 2022-09-21 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Calcium-gated potassium channel blockade via membrane-facing fenestrations. Nat.Chem.Biol., 2023
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5BKJ
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![BU of 5bkj by Molmil](/molmil-images/mine/5bkj) | TPeA-bound closed MthK channel in nanodisc | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1-(tripentyl-$l^{4}-azanyl)pentane, Calcium-gated potassium channel MthK, ... | 著者 | Fan, C, Nimigean, C.M. | 登録日 | 2021-03-19 | 公開日 | 2022-09-21 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Calcium-gated potassium channel blockade via membrane-facing fenestrations. Nat.Chem.Biol., 2023
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5BKK
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![BU of 5bkk by Molmil](/molmil-images/mine/5bkk) | bbTBA-bound closed MthK channel in nanodisc | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, (~{R})-phenyl-[4-[(tributyl-$l^{4}-azanyl)methyl]phenyl]methanol, Calcium-gated potassium channel MthK, ... | 著者 | Fan, C, Nimigean, C.M. | 登録日 | 2021-03-19 | 公開日 | 2022-09-21 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Calcium-gated potassium channel blockade via membrane-facing fenestrations. Nat.Chem.Biol., 2023
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5E1A
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![BU of 5e1a by Molmil](/molmil-images/mine/5e1a) | Structure of KcsA with L24C/R117C mutations | 分子名称: | POTASSIUM ION, antibody Fab fragment heavy chain, antibody Fab fragment light chain, ... | 著者 | Upadhyay, V, Kim, D.M, Nimigean, C.M. | 登録日 | 2015-09-29 | 公開日 | 2016-07-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles. J.Gen.Physiol., 148, 2016
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