4R7N
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![BU of 4r7n by Molmil](/molmil-images/mine/4r7n) | Fab C2E3 | 分子名称: | Fab C2E3 Heavy chain, Fab C2E3 Light chain | 著者 | Loyau, J, Didelot, G, Malinge, P, Ravn, U, Magistrelli, G, Depoisier, J.F, Kosco-Vilbois, M, Fischer, N, Thore, S, Rousseau, F. | 登録日 | 2014-08-28 | 公開日 | 2015-07-29 | 最終更新日 | 2015-08-26 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Robust Antibody-Antigen Complexes Prediction Generated by Combining Sequence Analyses, Mutagenesis, In Vitro Evolution, X-ray Crystallography and In Silico Docking. J.Mol.Biol., 427, 2015
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4R7D
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![BU of 4r7d by Molmil](/molmil-images/mine/4r7d) | Fab Hu 15C1 | 分子名称: | Fab Hu 15C1 Heavy chain, Fab Hu 15C1 Light chain | 著者 | Loyau, J, Didelot, G, Malinge, P, Ravn, U, Magistrelli, G, Depoisier, J.F, Kosco-Vilbois, M, Fischer, N, Thore, S, Rousseau, F. | 登録日 | 2014-08-27 | 公開日 | 2015-07-29 | 最終更新日 | 2015-08-26 | 実験手法 | X-RAY DIFFRACTION (2.753 Å) | 主引用文献 | Robust Antibody-Antigen Complexes Prediction Generated by Combining Sequence Analyses, Mutagenesis, In Vitro Evolution, X-ray Crystallography and In Silico Docking. J.Mol.Biol., 427, 2015
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3I0N
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![BU of 3i0n by Molmil](/molmil-images/mine/3i0n) | Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain | 分子名称: | DNA repair and telomere maintenance protein nbs1, GLYCEROL | 著者 | Clapperton, J.A, Lloyd, J, Chapman, J.R, Jackson, S.P, Smerdon, S.J. | 登録日 | 2009-06-25 | 公開日 | 2009-10-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage Cell(Cambridge,Mass.), 139, 2009
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3I0M
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![BU of 3i0m by Molmil](/molmil-images/mine/3i0m) | Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain | 分子名称: | DNA repair and telomere maintenance protein nbs1, GLYCEROL | 著者 | Clapperton, J.A, Lloyd, J, Chapman, J.R, Jackson, S.P, Smerdon, S.J. | 登録日 | 2009-06-25 | 公開日 | 2009-10-13 | 最終更新日 | 2012-05-02 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage Cell(Cambridge,Mass.), 139, 2009
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3UN0
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![BU of 3un0 by Molmil](/molmil-images/mine/3un0) | Crystal Structure of MDC1 FHA Domain | 分子名称: | Mediator of DNA damage checkpoint protein 1, SULFATE ION | 著者 | Clapperton, J.A, Lloyd, J, Haire, L.F, Li, J, Smerdon, S.J. | 登録日 | 2011-11-15 | 公開日 | 2011-12-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator. Nucleic Acids Res., 40, 2012
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3UOT
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![BU of 3uot by Molmil](/molmil-images/mine/3uot) | Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus | 分子名称: | Mediator of DNA damage checkpoint protein 1 | 著者 | Clapperton, J.A, Lloyd, J, Haire, L.F, Li, J, Smerdon, S.J. | 登録日 | 2011-11-17 | 公開日 | 2011-12-28 | 最終更新日 | 2012-07-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator. Nucleic Acids Res., 40, 2012
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1DDJ
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![BU of 1ddj by Molmil](/molmil-images/mine/1ddj) | CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN | 分子名称: | PLASMINOGEN | 著者 | Wang, X, Terzyan, S, Tang, J, Loy, J, Lin, X, Zhang, X. | 登録日 | 1999-11-10 | 公開日 | 2000-02-18 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Human plasminogen catalytic domain undergoes an unusual conformational change upon activation. J.Mol.Biol., 295, 2000
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7D5L
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![BU of 7d5l by Molmil](/molmil-images/mine/7d5l) | Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection | 分子名称: | NS3/4A Protease, ZINC ION, [1,1,1-tris(fluoranyl)-2-methyl-propan-2-yl] ~{N}-[(1~{S},4~{R},6~{S},7~{Z},11~{R},13~{R},14~{S},18~{R})-13-ethyl-18-(7-fluoranyl-6-methoxy-isoquinolin-1-yl)oxy-11-methyl-4-[(1-methylcyclopropyl)sulfonylcarbamoyl]-2,15-bis(oxidanylidene)-3,16-diazatricyclo[14.3.0.0^{4,6}]nonadec-7-en-14-yl]carbamate | 著者 | Ghosh, K, Anumula, R, Kumar, A. | 登録日 | 2020-09-26 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 63, 2020
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8VDJ
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![BU of 8vdj by Molmil](/molmil-images/mine/8vdj) | Crystal structure of SARS-CoV-2 3CL protease (3CLpro) as a covalent complex with EDP-235 | 分子名称: | 3C-like proteinase nsp5, 4,6,7-trifluoro-N-{(2S)-1-[(3R,5'R)-5'-(iminomethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-1'-yl]-4-methyl-1-oxopentan-2-yl}-N-methyl-1H-indole-2-carboxamide, THIOCYANATE ION | 著者 | Cade, I.A, Rhodin, M.H.J. | 登録日 | 2023-12-15 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo. Nat Commun, 15, 2024
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6N7B
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![BU of 6n7b by Molmil](/molmil-images/mine/6n7b) | Structure of the human JAK1 kinase domain with compound 38 | 分子名称: | GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-1H-pyrazolo[4,3-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N7C
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![BU of 6n7c by Molmil](/molmil-images/mine/6n7c) | Structure of the human JAK1 kinase domain with compound 56 | 分子名称: | GLYCEROL, N-[5-(3-methoxynaphthalen-2-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N79
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![BU of 6n79 by Molmil](/molmil-images/mine/6n79) | Structure of the human JAK1 kinase domain with compound 20 | 分子名称: | GLYCEROL, N-{5-[5-chloro-2-(difluoromethoxy)phenyl]-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N78
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![BU of 6n78 by Molmil](/molmil-images/mine/6n78) | Structure of the human JAK1 kinase domain with compound 21 | 分子名称: | GLYCEROL, N-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N7A
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![BU of 6n7a by Molmil](/molmil-images/mine/6n7a) | Structure of the human JAK1 kinase domain with compound 39 | 分子名称: | GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-2-methyl-2H-pyrazolo[4,3-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N77
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![BU of 6n77 by Molmil](/molmil-images/mine/6n77) | Structure of the human JAK1 kinase domain with compound 15 | 分子名称: | GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N7D
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![BU of 6n7d by Molmil](/molmil-images/mine/6n7d) | Structure of the human JAK1 kinase domain with compound 54 | 分子名称: | GLYCEROL, N-[5-(6-methoxy-1H-indazol-5-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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3MAC
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![BU of 3mac by Molmil](/molmil-images/mine/3mac) | crystal structure of GP41-derived protein complexed with fab 8062 | 分子名称: | Fab8062, Transmembrane glycoprotein | 著者 | Li, M, Gustchina, E, Louis, J, Gustchina, A, Wlodawer, A, Clore, M. | 登録日 | 2010-03-23 | 公開日 | 2010-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41. Plos Pathog., 6, 2010
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3MA9
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![BU of 3ma9 by Molmil](/molmil-images/mine/3ma9) | Crystal structure of gp41 derived protein complexed with fab 8066 | 分子名称: | Fab8066 FAB ANTIBODY FRAGMENT, Heavy Chain, Light Chain, ... | 著者 | Li, M, Gustchina, E, Louis, J, Gustchina, A, Wlodawer, A, Clore, M. | 登録日 | 2010-03-23 | 公開日 | 2010-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41. Plos Pathog., 6, 2010
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6RNX
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![BU of 6rnx by Molmil](/molmil-images/mine/6rnx) | Crystal structure of the essential repressor DdrO from radiation-resistant Deinococcus bacteria (Deinococcus deserti) | 分子名称: | CHLORIDE ION, HTH-type transcriptional regulator DdrOC | 著者 | Arnoux, P, Siponen, M.I, Pignol, D, De Groot, A, Blanchard, L. | 登録日 | 2019-05-09 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus. Nucleic Acids Res., 47, 2019
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6RMQ
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![BU of 6rmq by Molmil](/molmil-images/mine/6rmq) | Crystal structure of a selenomethionine-substituted A70M I84M mutant of the essential repressor DdrO from radiation resistant-Deinococcus bacteria (Deinococcus deserti) | 分子名称: | HTH-type transcriptional regulator DdrOC | 著者 | Arnoux, P, Siponen, M.I, Pignol, D, De Groot, A, Blanchard, L. | 登録日 | 2019-05-07 | 公開日 | 2019-10-09 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus. Nucleic Acids Res., 47, 2019
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6RNZ
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![BU of 6rnz by Molmil](/molmil-images/mine/6rnz) | Crystal structure of the N-terminal HTH DNA-binding domain of the essential repressor DdrO from radiation-resistant Deinococcus bacteria (Deinococcus deserti) | 分子名称: | GLYCEROL, HTH-type transcriptional regulator DdrOC | 著者 | Arnoux, P, Siponen, M.I, Pignol, D, Brandelet, G, De Groot, A, Blanchard, L. | 登録日 | 2019-05-10 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus. Nucleic Acids Res., 47, 2019
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6RO6
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![BU of 6ro6 by Molmil](/molmil-images/mine/6ro6) | Crystal structure of the C-terminal dimerization domain of the essential repressor DdrO from radiation-resistant Deinococcus bacteria (Deinococcus deserti) | 分子名称: | HTH-type transcriptional regulator DdrOC, SULFATE ION | 著者 | Pignol, D, Arnoux, P, Siponen, M.I, Brandelet, G, De Groot, A, Blanchard, L. | 登録日 | 2019-05-10 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus. Nucleic Acids Res., 47, 2019
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