6RMH
 
 | | The Rigid-body refined model of the normal Huntingtin. | | 分子名称: | Huntingtin | | 著者 | Jung, T, Tamo, G, Dal Perraro, M, Hebert, H, Song, J. | | 登録日 | 2019-05-06 | | 公開日 | 2020-06-03 | | 最終更新日 | 2020-12-16 | | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | | 主引用文献 | The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.
Structure, 28, 2020
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6YEJ
 | | Cryo-EM structure of the Full-length disease type human Huntingtin | | 分子名称: | Huntingtin | | 著者 | Tame, G, Jung, T, Dal Perraro, M, Hebert, H, Song, J. | | 登録日 | 2020-03-24 | | 公開日 | 2020-12-16 | | 実験手法 | ELECTRON MICROSCOPY (18.200001 Å) | | 主引用文献 | The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.
Structure, 28, 2020
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7XMH
 | | Crystal structure of a rice class IIIb chitinase, Oschib2 | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Putative class III chitinase | | 著者 | Jun, T, Tomoya, T, Tomoyuki, N, Takayuki, O. | | 登録日 | 2022-04-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Characterization of two rice GH18 chitinases belonging to family 8 of plant pathogenesis-related proteins.
Plant Sci., 326, 2023
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4UW2
 | | Crystal structure of Csm1 in T.onnurineus | | 分子名称: | CSM1 | | 著者 | Jung, T.Y, An, Y, Park, K.H, Lee, M.H, Oh, B.H, Woo, E.J. | | 登録日 | 2014-08-08 | | 公開日 | 2015-03-25 | | 最終更新日 | 2015-09-23 | | 実験手法 | X-RAY DIFFRACTION (2.632 Å) | | 主引用文献 | Crystal Structure of the Csm1 Subunit of the Csm Complex and its Single-Stranded DNA-Specific Nuclease Activity.
Structure, 23, 2015
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5G4D
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8PFI
 | | Crystal structure of human TLR8 in complex with compound 34 | | 分子名称: | (3~{S})-~{N}-[4-[[5-(1,6-dimethylpyrazolo[3,4-b]pyridin-4-yl)-3-methyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-1-yl]methyl]-1-bicyclo[2.2.2]octanyl]morpholine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | | 著者 | Faller, M, Zink, F. | | 登録日 | 2023-06-16 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.785 Å) | | 主引用文献 | Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases.
Acs Med.Chem.Lett., 14, 2023
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5XBK
 | | Crystal structure of human Importin4 | | 分子名称: | Importin-4, histone H3 | | 著者 | Song, J.J, Yoon, J. | | 登録日 | 2017-03-20 | | 公開日 | 2018-02-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.223 Å) | | 主引用文献 | Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding
J. Mol. Biol., 430, 2018
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7R53
 | | Crystal structure of human TLR8 in complex with Compound 15 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-~{N}-[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]-1~{H}-indazol-3-amine, Toll-like receptor 8, ... | | 著者 | Faller, M, Zink, F. | | 登録日 | 2022-02-10 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.121 Å) | | 主引用文献 | Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.
Acs Med.Chem.Lett., 13, 2022
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7R52
 | | Crystal structure of human TLR8 in complex with Compound 2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methoxy-6-pyridin-4-yl-1~{H}-indole, Toll-like receptor 8, ... | | 著者 | Faller, M, Zink, F. | | 登録日 | 2022-02-10 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.943 Å) | | 主引用文献 | Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.
Acs Med.Chem.Lett., 13, 2022
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7R54
 | | Crystal structure of human TLR8 in complex with Compound 4 | | 分子名称: | (5-methoxy-6-pyridin-4-yl-1~{H}-indazol-3-yl)-(4-methylpiperazin-1-yl)methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | | 著者 | Faller, M, Zink, F. | | 登録日 | 2022-02-10 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.836 Å) | | 主引用文献 | Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.
Acs Med.Chem.Lett., 13, 2022
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6TY5
 | | Crystal structure of human TLR8 in complex with Compound 11 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methyl-7-(7-methyl-2-piperidin-4-yl-indazol-5-yl)furo[3,2-c]pyridin-4-one, Toll-like receptor 8, ... | | 著者 | Faller, M, Zink, F. | | 登録日 | 2020-01-15 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.793 Å) | | 主引用文献 | Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.
J.Med.Chem., 63, 2020
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8SVE
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8DNX
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8DNY
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8DNZ
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8DO3
 | | Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I | | 分子名称: | N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | | 著者 | Park, E, Itskanov, S. | | 登録日 | 2022-07-12 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
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8DNV
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8DNW
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8DO0
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8DO1
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8DO2
 | | Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) | | 分子名称: | 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | | 著者 | Park, E, Itskanov, S. | | 登録日 | 2022-07-12 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
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4IXD
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5XAH
 | | Crystal structure of human Importin4 | | 分子名称: | Importin-4 | | 著者 | Song, J.J, Yoon, J. | | 登録日 | 2017-03-13 | | 公開日 | 2018-02-14 | | 最終更新日 | 2018-04-11 | | 実験手法 | X-RAY DIFFRACTION (3.004 Å) | | 主引用文献 | Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding
J. Mol. Biol., 430, 2018
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6AHC
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6JM9
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