8F17
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![BU of 8f17 by Molmil](/molmil-images/mine/8f17) | Structure of the STUB1 TPR domain in complex with H204, an all-D Helicon Polypeptide | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CHIP, N,N'-(1,4-phenylene)diacetamide, ... | 著者 | Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. | 登録日 | 2022-11-04 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
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8F15
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![BU of 8f15 by Molmil](/molmil-images/mine/8f15) | Structure of the STUB1 TPR domain in complex with H202, an all-D Helicon Polypeptide | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CHIP, N,N'-(1,4-phenylene)diacetamide, ... | 著者 | Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. | 登録日 | 2022-11-04 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
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8F16
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![BU of 8f16 by Molmil](/molmil-images/mine/8f16) | Structure of the STUB1 TPR domain in complex with H203, an all-D Helicon Polypeptide | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CHIP, N,N'-(1,4-phenylene)diacetamide, ... | 著者 | Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. | 登録日 | 2022-11-04 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
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4PAR
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![BU of 4par by Molmil](/molmil-images/mine/4par) | The 5-Hydroxymethylcytosine-Specific Restriction Enzyme AbaSI in a Complex with Product-like DNA | 分子名称: | 1,2-ETHANEDIOL, DNA 14-MER, DNA 18-MER, ... | 著者 | Horton, J.R, Cheng, X. | 登録日 | 2014-04-09 | 公開日 | 2014-06-25 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA. Nucleic Acids Res., 42, 2014
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7T2P
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![BU of 7t2p by Molmil](/molmil-images/mine/7t2p) | |
7T4G
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![BU of 7t4g by Molmil](/molmil-images/mine/7t4g) | |
6NAO
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![BU of 6nao by Molmil](/molmil-images/mine/6nao) | Discovery of a high affinity inhibitor of cGAS | 分子名称: | (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid, CYCLIC GMP-AMP SYNTHASE, ZINC ION | 著者 | Hall, J. | 登録日 | 2018-12-06 | 公開日 | 2018-12-19 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | 主引用文献 | Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE, 12, 2017
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8F0Z
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![BU of 8f0z by Molmil](/molmil-images/mine/8f0z) | Structure of the MDM2 P53 binding domain in complex with H101, an all-D Helicon Polypeptide | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, H101, ... | 著者 | Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. | 登録日 | 2022-11-04 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
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8F10
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![BU of 8f10 by Molmil](/molmil-images/mine/8f10) | Structure of the MDM2 P53 binding domain in complex with H102, an all-D Helicon Polypeptide | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... | 著者 | Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. | 登録日 | 2022-11-04 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
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8F14
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![BU of 8f14 by Molmil](/molmil-images/mine/8f14) | Structure of the STUB1 TPR domain in complex with H201, an all-D Helicon Polypeptide | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CHIP, N,N'-(1,4-phenylene)diacetamide, ... | 著者 | Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. | 登録日 | 2022-11-04 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
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7M6E
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![BU of 7m6e by Molmil](/molmil-images/mine/7m6e) | |
7M6G
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![BU of 7m6g by Molmil](/molmil-images/mine/7m6g) | |
7M6H
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![BU of 7m6h by Molmil](/molmil-images/mine/7m6h) | |
7M6D
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![BU of 7m6d by Molmil](/molmil-images/mine/7m6d) | |
6S0K
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![BU of 6s0k by Molmil](/molmil-images/mine/6s0k) | Ribosome nascent chain in complex with SecA | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | 著者 | Jomaa, A, Wang, S, Shan, S, Ban, N. | 登録日 | 2019-06-17 | 公開日 | 2019-10-09 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | The molecular mechanism of cotranslational membrane protein recognition and targeting by SecA. Nat.Struct.Mol.Biol., 26, 2019
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6Z45
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![BU of 6z45 by Molmil](/molmil-images/mine/6z45) | CDK9-Cyclin-T1 complex bound by compound 24 | 分子名称: | (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... | 著者 | Ferguson, A, Collie, G.W. | 登録日 | 2020-05-22 | 公開日 | 2020-12-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
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7SRS
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![BU of 7srs by Molmil](/molmil-images/mine/7srs) | 5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM) | 分子名称: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 2B, ... | 著者 | Barros-Alvarez, X, Cao, C, Panova, O, Roth, B.L, Skiniotis, G. | 登録日 | 2021-11-08 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7SRQ
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![BU of 7srq by Molmil](/molmil-images/mine/7srq) | 5-HT2B receptor bound to LSD obtained by cryo-electron microscopy (cryoEM) | 分子名称: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 2B | 著者 | Barros-Alvarez, X, Cao, C, Panova, O, Roth, B.L, Skiniotis, G. | 登録日 | 2021-11-08 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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5FGJ
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![BU of 5fgj by Molmil](/molmil-images/mine/5fgj) | Structure of tetrameric rat phenylalanine hydroxylase, residues 1-453 | 分子名称: | FE (III) ION, MAGNESIUM ION, Phenylalanine-4-hydroxylase | 著者 | Taylor, A.B, Roberts, K.M, Fitzpatrick, P.F. | 登録日 | 2015-12-20 | 公開日 | 2016-05-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering. J.Am.Chem.Soc., 138, 2016
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7SRR
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![BU of 7srr by Molmil](/molmil-images/mine/7srr) | 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM) | 分子名称: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2B, G protein subunit q (Gi2-mini-Gq chimera), ... | 著者 | Barros-Alvarez, X, Kim, K, Panova, O, Cao, C, Roth, B.L, Skiniotis, G. | 登録日 | 2021-11-08 | 公開日 | 2022-09-21 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7RE5
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![BU of 7re5 by Molmil](/molmil-images/mine/7re5) | |
6NQD
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7RCU
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![BU of 7rcu by Molmil](/molmil-images/mine/7rcu) | Synthetic Max homodimer mimic in complex with DNA | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2-(2,5-dioxopyrrolidin-1-yl)acetamide, ACETAMIDE, ... | 著者 | Speltz, T, Qiao, Z, Shangguan, S, Fanning, S, Greene, J, Moellering, R. | 登録日 | 2021-07-08 | 公開日 | 2022-09-14 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat.Biotechnol., 41, 2023
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7X2M
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![BU of 7x2m by Molmil](/molmil-images/mine/7x2m) | Crystal structure of nanobody 1-2C7 with SARS-CoV-2 RBD | 分子名称: | 1-2C7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1 | 著者 | Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X. | 登録日 | 2022-02-25 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses. Nat Commun, 13, 2022
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7X2J
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![BU of 7x2j by Molmil](/molmil-images/mine/7x2j) | Crystal structure of nanobody Nb70 with SARS-CoV RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nb70, Spike protein S1 | 著者 | Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X. | 登録日 | 2022-02-25 | 公開日 | 2022-12-21 | 最終更新日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses. Nat Commun, 13, 2022
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