8IUF
| Cryo-EM structure of Euglena gracilis super-complex I+III2+IV, composite | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | 著者 | Wu, M.C, Tian, H.T, He, Z.X, Hu, Y.Q, Zhou, L. | 登録日 | 2023-03-24 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8J9H
| Cryo-EM structure of Euglena gracilis respiratory complex I, deactive state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | 著者 | Wu, M.C, He, Z.X, Tian, H.T, Hu, Y.Q, Han, F.Z, Zhou, L. | 登録日 | 2023-05-03 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8J9I
| Cryo-EM structure of Euglena gracilis complex I, turnover state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | 著者 | Wu, M.C, He, Z.X, Tian, H.T, Hu, Y.Q, Han, F.Z, Zhou, L. | 登録日 | 2023-05-03 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8IUJ
| Cryo-EM structure of Euglena gracilis super-complex III2+IV2, composite | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | 著者 | Wu, M.C, Tian, H.T, He, Z.X, Hu, Y.Q, Zhou, L. | 登録日 | 2023-03-24 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8J9J
| Cryo-EM structure of Euglena gracilis complex I, NADH state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | 著者 | Wu, M.C, He, Z.X, Tian, H.T, Hu, Y.Q, Han, F.Z, Zhou, L. | 登録日 | 2023-05-03 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8JC5
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8JCA
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5EWS
| Sugar binding protein - human galectin-2 | 分子名称: | Galectin-2, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | 著者 | Su, J.Y, Si, Y.L. | 登録日 | 2015-11-21 | 公開日 | 2016-09-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutination. Acta Biochim. Biophys. Sin. (Shanghai), 48, 2016
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6X1C
| Tubulin-RB3_SLD-TTL in complex with compound 5j | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chlorofuro[3,2-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2020-05-18 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
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6X1F
| Tubulin-RB3_SLD-TTL in complex with compound 5m | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-methoxy-4-(2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2020-05-18 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
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6X1E
| Tubulin-RB3_SLD-TTL in complex with compound 5l | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2020-05-18 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64, 2021
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8K6P
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8K6Q
| Crystal structure of HOIL-1L LTM domain | 分子名称: | RanBP-type and C3HC4-type zinc finger-containing protein 1 | 著者 | Yan, Z, Pan, L.F. | 登録日 | 2023-07-25 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN. Biochem.Biophys.Res.Commun., 689, 2023
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7DF3
| SARS-CoV-2 S trimer, S-closed | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Cong, X, Yao, C. | 登録日 | 2020-11-06 | 公開日 | 2020-12-16 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. Sci Adv, 7, 2021
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7DF4
| SARS-CoV-2 S-ACE2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Cong, X, Yao, C. | 登録日 | 2020-11-06 | 公開日 | 2020-12-16 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. Sci Adv, 7, 2021
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7VJL
| The crystal structure of FGFR4 kinase domain in complex with N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(2,2,2-trifluoroacetyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide | 分子名称: | Fibroblast growth factor receptor 4, N-[5-(aminomethyl)-4-(2-methoxyethylamino)pyridin-2-yl]-7-[2,2,2-tris(fluoranyl)ethanoyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide | 著者 | Zhang, Z.M, Wang, Y.J. | 登録日 | 2021-09-28 | 公開日 | 2022-02-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.900173 Å) | 主引用文献 | Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design. Bioorg.Med.Chem., 50, 2021
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7CYP
| Complex of SARS-CoV-2 spike trimer with its neutralizing antibody HB27 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of HB27, ... | 著者 | Wang, X, Zhu, L. | 登録日 | 2020-09-04 | 公開日 | 2021-06-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2. Natl Sci Rev, 8, 2021
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8IWO
| The rice Na+/H+ antiporter SOS1 in an auto-inhibited state | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, OsSOS1 | 著者 | Zhang, X.Y, Tang, L.H, Zhang, C.R, Nie, J.W. | 登録日 | 2023-03-30 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na + /H + antiporter. Nat.Plants, 9, 2023
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3KMY
| Structure of BACE bound to SCH12472 | 分子名称: | 3-[2-(3-chlorophenyl)ethyl]pyridin-2-amine, Beta-secretase 1 | 著者 | Strickland, C, Wang, Y. | 登録日 | 2009-11-11 | 公開日 | 2010-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors. J.Med.Chem., 53, 2010
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7DK3
| SARS-CoV-2 S trimer, S-open | 分子名称: | Spike glycoprotein | 著者 | Xu, C, Cong, Y. | 登録日 | 2020-11-23 | 公開日 | 2020-12-16 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. Sci Adv, 7, 2021
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8JEU
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8JET
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8JEC
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5W0T
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3KMX
| Structure of BACE bound to SCH346572 | 分子名称: | 4-butoxy-3-chlorobenzyl imidothiocarbamate, Beta-secretase 1 | 著者 | Strickland, C, Wang, Y. | 登録日 | 2009-11-11 | 公開日 | 2010-01-19 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors. J.Med.Chem., 53, 2010
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