8FYO
| MicroED structure of Proteinase K from lamellae milled from multiple plasma sources | 分子名称: | CALCIUM ION, NITRATE ION, Proteinase K | 著者 | Martynowycz, M.W, Shiriaeva, A, Clabbers, M.T.B, Nicolas, W.J, Weaver, S.J, Hattne, J, Gonen, T. | 登録日 | 2023-01-26 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.39 Å) | 主引用文献 | A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals. Nat Commun, 14, 2023
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6MGY
| Crystal Structure of the New Deli Metallo Beta Lactamase Variant 5 from Klebsiella pneumoniae | 分子名称: | GLYCEROL, Metallo-beta-lactamase NDM-5, POTASSIUM ION, ... | 著者 | Kim, Y, Tesar, C, Jedrzejczak, R, Babnigg, G, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2018-09-16 | 公開日 | 2018-10-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal Structure of the New Deli Metallo Beta Lactamase Variant 5 from Klebsiella pneumoniae To Be Published
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3MSE
| Crystal structure of C-terminal domain of PF110239. | 分子名称: | CALCIUM ION, Calcium-dependent protein kinase, putative, ... | 著者 | Wernimont, A.K, Artz, J.D, Hutchinson, A, Sullivan, H, Weadge, J, Tempel, W, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Lin, Y.H, Neculai, A.M, Amani, M, Structural Genomics Consortium (SGC) | 登録日 | 2010-04-29 | 公開日 | 2010-06-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of C-terminal domain of PF110239 To be Published
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6SEB
| Cold-adapted beta-D-galactosidase from Arthrobacter sp. 32cB in complex with IPTG | 分子名称: | 1-methylethyl 1-thio-beta-D-galactopyranoside, ACETATE ION, Beta-galactosidase, ... | 著者 | Rutkiewicz, M, Bujacz, A, Kaminska, P, Bujacz, G. | 登録日 | 2019-07-29 | 公開日 | 2019-09-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.272 Å) | 主引用文献 | Active Site Architecture and Reaction Mechanism Determination of Cold Adapted beta-d-galactosidase fromArthrobactersp. 32cB. Int J Mol Sci, 20, 2019
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8FOB
| Cryo-EM structure of human TRPV6 in the open state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2022-12-30 | 公開日 | 2023-05-24 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14, 2023
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8FOA
| Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2022-12-30 | 公開日 | 2023-05-24 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14, 2023
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1ENX
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8FSI
| The structure of a crystallizable variant of E. coli pyruvate formate-lyase activating enzyme bound to SAM | 分子名称: | CHLORIDE ION, IRON/SULFUR CLUSTER, POTASSIUM ION, ... | 著者 | Moody, J.D, Galambas, A, Lawrence, C.M, Broderick, J.B. | 登録日 | 2023-01-10 | 公開日 | 2023-05-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage. J.Biol.Chem., 299, 2023
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6N1R
| Tetrahedral oligomeric complex of GyrA N-terminal fragment, solved by cryoEM in tetrahedral symmetry | 分子名称: | DNA gyrase subunit A | 著者 | Soczek, K.M, Grant, T, Rosenthal, P.B, Mondragon, A. | 登録日 | 2018-11-10 | 公開日 | 2018-12-05 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage. Elife, 7, 2018
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6MJU
| human cGAS catalytic domain bound with the inhibitor G108 | 分子名称: | 1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T. | 登録日 | 2018-09-22 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10, 2019
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6N2V
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6N36
| Beta-lactamase from Chitinophaga pinensis | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, ZINC ION | 著者 | Osipiuk, J, Tesar, C, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2018-11-14 | 公開日 | 2018-11-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Beta-lactamase from Chitinophaga pinensis to be published
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6MK1
| Cryo-EM of self-assembly peptide filament HEAT_R1 | 分子名称: | peptide HEAT_R1 | 著者 | Wang, F, Hughes, S.A, Orlova, A, Conticello, V.P, Egelman, E.H. | 登録日 | 2018-09-24 | 公開日 | 2019-06-26 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs. Proc.Natl.Acad.Sci.USA, 116, 2019
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6Y4V
| Crystal structure of p38 in complex with SR68 | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-(3-methylbutylamino)-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Chaikuad, A, Roehm, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-23 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
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6MLB
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6MLL
| Crystal structure of KPC-2 with compound 7 | 分子名称: | 1,5-diphenyl-N-(1H-tetrazol-5-yl)-1H-pyrazole-3-carboxamide, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL | 著者 | Akhtar, A, Chen, Y. | 登録日 | 2018-09-27 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. Acs Infect Dis., 5, 2019
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5A7W
| Crystal structure of human JMJD2A in complex with compound 35 | 分子名称: | 1,2-ETHANEDIOL, 2-[5-[(4-hydroxyphenyl)carbonylamino]-2-oxidanyl-phenyl]pyridine-4-carboxylic acid, DIMETHYL SULFOXIDE, ... | 著者 | Nowak, R, Velupillai, S, Krojer, T, Gileadi, C, Johansson, C, Korczynska, M, Le, D.D, Younger, N, Gregori-Puigjane, E, Tumber, A, Iwasa, E, Pollock, S.B, Ortiz Torres, I, Kopec, J, Tallant, C, Froese, S, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Shoichet, B.K, Fujimori, D.G, Oppermann, U. | 登録日 | 2015-07-10 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Docking and Linking of Fragments to Discover Jumonji Histone Demethylase Inhibitors. J.Med.Chem., 59, 2016
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6MLT
| Crystal structure of the V. cholerae biofilm matrix protein Bap1 | 分子名称: | CALCIUM ION, CITRATE ANION, GLYCEROL, ... | 著者 | Kaus, K, Biester, A, Chupp, E, Lu, K, Vidsudharomn, C, Olson, R. | 登録日 | 2018-09-28 | 公開日 | 2019-08-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The 1.9 angstrom crystal structure of the extracellular matrix protein Bap1 fromVibrio choleraeprovides insights into bacterial biofilm adhesion. J.Biol.Chem., 294, 2019
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2MD2
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3M6U
| Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group 43 | 分子名称: | SULFATE ION, rRNA methylase | 著者 | Demirci, H, Larsen, H.G.L, Hansen, T, Rasmussen, A, Cadambi, A, Gregory, S.T, Kirpekar, F, Jogl, G. | 登録日 | 2010-03-16 | 公開日 | 2010-03-31 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.402 Å) | 主引用文献 | Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Rna, 16, 2010
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6N91
| Crystal Structure of Adenosine Deaminase from Vibrio cholerae Complexed with Pentostatin (Deoxycoformycin) | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYCOFORMYCIN, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... | 著者 | Maltseva, N, Kim, Y, Endres, M, Welk, L, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2018-11-30 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal Structure of Adenosine Deaminase from Vibrio cholerae Complexed with Pentostatin (Deoxycoformycin) (CASP target) To Be Published
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5DXU
| p110delta/p85alpha with GDC-0326 | 分子名称: | (2S)-2-({2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 著者 | Heffron, T.P, Heald, R.A, Ndubaku, C, Wei, B.Q, Augustin, M, Do, S, Edgar, K, Eigenbrot, C, Friedman, L, Gancia, E, Jackson, P.S, Jones, G, Kolesnikov, A, Lee, L.B, Lesnick, J.D, Lewis, C, McLean, N, Mortle, M, Nonomiya, J, Pang, J, Price, S, Prior, W.W, Salphati, L, Sideris, S, Staben, S.T, Steinbacher, S, Tsui, V, Wallin, J, Sampath, D, Olivero, A. | 登録日 | 2015-09-23 | 公開日 | 2016-01-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326). J.Med.Chem., 59, 2016
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6MGE
| Structure of human 4-1BBL | 分子名称: | GLYCEROL, PHOSPHATE ION, Tumor necrosis factor ligand superfamily member 9 | 著者 | Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. | 登録日 | 2018-09-13 | 公開日 | 2018-11-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab. Nat Commun, 9, 2018
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6MR0
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6MGV
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