4QBZ
 
 | | Crystal structure of human TLR8 in complex with DS-802 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl[1,3]oxazolo[4,5-c]quinolin-4-amine, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2014-05-09 | | 公開日 | 2014-10-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
J.Med.Chem., 57, 2014
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5JKE
 | | Crystal structure of human IZUMO1-JUNO complex (crystal form 3) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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5JKD
 | | Crystal structure of human IZUMO1-JUNO complex (crystal form 2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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5JK9
 | | Crystal structure of human IZUMO1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Izumo sperm-egg fusion protein 1 | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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4R6A
 | | Crystal structure of human TLR8 in complex with Hybrid-2 | | 分子名称: | 1-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2014-08-22 | | 公開日 | 2015-08-26 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Hybrid-2: AnImidazoquinoline Dual Toll-like receptor 7/8 Agonist that Potently Activates Cytokine Production by Human Newborn and Adult Leukocytes
To be Published
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1A2B
 | | HUMAN RHOA COMPLEXED WITH GTP ANALOGUE | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, TRANSFORMING PROTEIN RHOA | | 著者 | Ihara, K, Muraguchi, S, Kato, M, Shimizu, T, Shirakawa, M, Kuroda, S, Kaibuchi, K, Hakoshima, T. | | 登録日 | 1997-12-26 | | 公開日 | 1998-06-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
J.Biol.Chem., 273, 1998
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3VQ1
 | | Crystal structure of mouse TLR4/MD-2/lipid IVa complex | | 分子名称: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2012-03-17 | | 公開日 | 2012-05-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Proc.Natl.Acad.Sci.USA, 109, 2012
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3VU7
 | | Crystal structure of REV1-REV7-REV3 ternary complex | | 分子名称: | DNA polymerase zeta catalytic subunit, DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B | | 著者 | Kikuchi, S, Hara, K, Shimizu, T, Sato, M, Hashimoto, H. | | 登録日 | 2012-06-20 | | 公開日 | 2012-08-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis of recruitment of DNA polymerase [zeta] by interaction between REV1 and REV7 proteins
J.Biol.Chem., 287, 2012
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3VQ2
 | | Crystal structure of mouse TLR4/MD-2/LPS complex | | 分子名称: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2012-03-17 | | 公開日 | 2012-05-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Proc.Natl.Acad.Sci.USA, 109, 2012
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3VIR
 | | Crystal strcture of Swi5 from fission yeast | | 分子名称: | Mating-type switching protein swi5, octyl beta-D-glucopyranoside | | 著者 | Kuwabara, N, Yamada, N, Hashimoto, H, Sato, M, Iwasaki, H, Shimizu, T. | | 登録日 | 2011-10-06 | | 公開日 | 2012-08-22 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex
Structure, 20, 2012
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8J6N
 | | Crystal structure of Cystathionine gamma-lyase in complex with compound 1 | | 分子名称: | 1,2-ETHANEDIOL, Cystathionine gamma-lyase, GLYCEROL, ... | | 著者 | Hibi, R, Toma-Fukai, S, Shimizu, T, Hanaoka, K. | | 登録日 | 2023-04-26 | | 公開日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.
Sci Rep, 13, 2023
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1GD2
 | | CRYSTAL STRUCTURE OF BZIP TRANSCRIPTION FACTOR PAP1 BOUND TO DNA | | 分子名称: | DNA (5'-D(*AP*GP*GP*TP*TP*AP*CP*GP*TP*AP*AP*CP*C)-3'), TRANSCRIPTION FACTOR PAP1 | | 著者 | Fujii, Y, Shimizu, T, Toda, T, Yanagida, M, Hakoshima, T. | | 登録日 | 2000-08-25 | | 公開日 | 2000-10-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for the diversity of DNA recognition by bZIP transcription factors.
Nat.Struct.Biol., 7, 2000
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5ZHX
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7WSI
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7YTP
 | | TLR7 in complex with an inhibitor | | 分子名称: | (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2022-08-15 | | 公開日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | TLR7 in complex with an inhibitor
To Be Published
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1GLN
 | | ARCHITECTURES OF CLASS-DEFINING AND SPECIFIC DOMAINS OF GLUTAMYL-TRNA SYNTHETASE | | 分子名称: | GLUTAMYL-TRNA SYNTHETASE | | 著者 | Nureki, O, Vassylyev, D.G, Katayanagi, K, Shimizu, T, Sekine, S, Kigawa, T, Miyazawa, T, Yokoyama, S, Morikawa, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 1994-07-20 | | 公開日 | 1995-10-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Architectures of class-defining and specific domains of glutamyl-tRNA synthetase.
Science, 267, 1995
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8ISN
 | | HLA-A24 in complex with modified 9mer WT1 peptide | | 分子名称: | Beta-2-microglobulin, CYS-TYR-THR-TRP-ASN-GLN-MET-ASN-LEU, GLYCEROL, ... | | 著者 | Bekker, G.J, Numoto, N, Kawasaki, M, Hayashi, T, Yabuno, S, Kozono, Y, Shimizu, T, Kozono, H, Ito, N, Oda, M, Kamiya, N. | | 登録日 | 2023-03-21 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Elucidation of binding mechanism, affinity, and complex structure between mWT1 tumor-associated antigen peptide and HLA-A*24:02.
Protein Sci., 32, 2023
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5GMF
 | | Crystal structure of monkey TLR7 in complex with guanosine and polyU | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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5GMG
 | | Crystal structure of monkey TLR7 in complex with loxoribine and polyU | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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5GMH
 | | Crystal structure of monkey TLR7 in complex with R848 | | 分子名称: | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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8K7T
 | | Mouse Fc epsilon RI in complex with mIgE Fc | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, High affinity immunoglobulin epsilon receptor subunit alpha, High affinity immunoglobulin epsilon receptor subunit beta, ... | | 著者 | Zhang, Z, Yui, M, Ohto, U, Shimizu, T. | | 登録日 | 2023-07-27 | | 公開日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Mouse Fc epsilon RI in complex withMouse Fc epsilon RI in complex with mIgE Fc mIgE Fc
To Be Published
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5H6K
 | | DNA targeting ADP-ribosyltransferase Pierisin-1 | | 分子名称: | 1,2-ETHANEDIOL, Pierisin-1 | | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | | 登録日 | 2016-11-14 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
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5H6M
 | | DNA targeting ADP-ribosyltransferase Pierisin-1 | | 分子名称: | 1,2-ETHANEDIOL, Pierisin-1 | | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | | 登録日 | 2016-11-14 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
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5H6N
 | | DNA targeting ADP-ribosyltransferase Pierisin-1, autoinhibitory form | | 分子名称: | Pierisin-1 | | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | | 登録日 | 2016-11-14 | | 公開日 | 2017-08-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
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5H6L
 | | DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+ | | 分子名称: | 1,2-ETHANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pierisin-1 | | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | | 登録日 | 2016-11-14 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
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