4IVB
| JAK1 kinase (JH1 domain) in complex with the inhibitor TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXANECARBONITRILE | 分子名称: | Tyrosine-protein kinase JAK1, trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile | 著者 | Eigenbrot, C, Steffek, M. | 登録日 | 2013-01-22 | 公開日 | 2013-05-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2. J.Med.Chem., 56, 2013
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4IVC
| JAK1 kinase (JH1 domain) in complex with the inhibitor (TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXYL)ACETONITRILE | 分子名称: | (trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexyl)acetonitrile, Tyrosine-protein kinase JAK1 | 著者 | Eigenbrot, C, Shia, S. | 登録日 | 2013-01-22 | 公開日 | 2013-05-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2. J.Med.Chem., 56, 2013
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8E4V
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3QYF
| Crystal structure of the CRISPR-associated protein SSO1393 from Sulfolobus solfataricus | 分子名称: | CRISPR-ASSOCIATED PROTEIN, MAGNESIUM ION | 著者 | Petit, P, Xu, X, Chang, C, Savchenko, A, Yakunin, A.F. | 登録日 | 2011-03-03 | 公開日 | 2011-03-23 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the CRISPR-associated protein SSO1393 from Sulfolobus solfataricus To be Published
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8DEH
| Ankyrin domain of SKD3 | 分子名称: | Caseinolytic peptidase B protein homolog | 著者 | Lee, S, Tsai, F.T.F. | 登録日 | 2022-06-20 | 公開日 | 2023-04-19 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.815 Å) | 主引用文献 | Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria. Nat Commun, 14, 2023
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3I9S
| Structure from the mobile metagenome of V.cholerae. Integron cassette protein VCH_CASS6 | 分子名称: | CHLORIDE ION, Integron cassette protein, SULFATE ION | 著者 | Deshpande, C.N, Sureshan, V, Harrop, S.J, Boucher, Y, Xu, X, Cui, H, Edwards, A, Savchenko, A, Joachimiak, A, Chang, C, Stokes, H.W, Curmi, P.M.G, Mabbutt, B.C, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2009-07-13 | 公開日 | 2009-08-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure from the mobile metagenome of V.cholerae. Integron cassette protein VCH_CASS6 To be Published
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4EVR
| Crystal structure of ABC transporter from R. palustris - solute binding protein (RPA0668) in complex with benzoate | 分子名称: | BENZOIC ACID, Putative ABC transporter subunit, substrate-binding component | 著者 | Michalska, K, Mack, J.C, Zerbs, S, Collart, F.R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2012-04-26 | 公開日 | 2012-05-23 | 最終更新日 | 2013-01-09 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Characterization of transport proteins for aromatic compounds derived from lignin: benzoate derivative binding proteins. J.Mol.Biol., 423, 2012
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4OKW
| Crystal structure of W741L-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, R-BICALUTAMIDE, co-regulator peptide | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-23 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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3TX6
| The Structure of a putative ABC-transporter periplasmic component from Rhodopseudomonas palustris | 分子名称: | 1,2-ETHANEDIOL, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ACETIC ACID, ... | 著者 | Cuff, M.E, Mack, J.C, Zerbs, S, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2011-09-22 | 公開日 | 2011-11-09 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural and functional characterization of solute binding proteins for aromatic compounds derived from lignin: p-Coumaric acid and related aromatic acids. Proteins, 81, 2013
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4OEA
| Crystal structure of AR-LBD | 分子名称: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-12 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4OFR
| Crystal structure of AR-LBD bound with co-regulator peptide | 分子名称: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, co-regulator peptide | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-15 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4OFU
| Crystal structure of AR-LBD bound with co-regulator peptide | 分子名称: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, co-regulator peptide | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-15 | 公開日 | 2014-08-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4EVQ
| Crystal structure of ABC transporter from R. palustris - solute binding protein (RPA0668) in complex with 4-hydroxybenzoate | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, GLYCEROL, ... | 著者 | Michalska, K, Mack, J.C, Zerbs, S, Collart, F.R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2012-04-26 | 公開日 | 2012-05-23 | 最終更新日 | 2013-01-09 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Characterization of transport proteins for aromatic compounds derived from lignin: benzoate derivative binding proteins. J.Mol.Biol., 423, 2012
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4OK1
| Crystal structure of W741L-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, R-BICALUTAMIDE, co-regulator peptide | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-21 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4OIU
| Crystal structure of T877A-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, HYDROXYFLUTAMIDE, co-regulator peptide | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-20 | 公開日 | 2014-08-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4OKT
| Crystal structure of W741L-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, R-BICALUTAMIDE, co-regulator peptide | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-22 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4OLM
| Crystal structure of W741L-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, R-BICALUTAMIDE, co-regulator peptide | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-24 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4OQJ
| Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmQ KS1 | 分子名称: | GLYCEROL, PHOSPHATE ION, PKS, ... | 著者 | Nocek, B, Mack, J, Endras, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2014-02-09 | 公開日 | 2014-03-19 | 最終更新日 | 2016-11-02 | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | 主引用文献 | Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
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5MMB
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ434 (compound 6p) | 分子名称: | DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), GLYCEROL, ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2016-12-09 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. J. Med. Chem., 60, 2017
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4OPE
| Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmH KS7 | 分子名称: | NITRATE ION, NRPS/PKS | 著者 | Osipiuk, J, Mack, J, Endres, M, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2014-02-05 | 公開日 | 2014-02-19 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
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4OH5
| Crystal structure of T877A-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, HYDROXYFLUTAMIDE, SULFATE ION, ... | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-17 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4OHA
| Crystal structure of T877A-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, HYDROXYFLUTAMIDE, SULFATE ION, ... | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-17 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4OJ9
| Crystal structure of T877A-AR-LBD bound with co-regulator peptide | 分子名称: | Androgen receptor, GLYCEROL, HYDROXYFLUTAMIDE, ... | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-20 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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5MMA
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ379 (compound 5'g) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... | 著者 | Maskell, D.P, Pye, V.E, Cherepanov, P. | 登録日 | 2016-12-09 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. J. Med. Chem., 60, 2017
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4OGH
| Crystal structure of T877A-AR-LBD | 分子名称: | Androgen receptor, HYDROXYFLUTAMIDE, SULFATE ION | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-16 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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