4R09
 
 | | Crystal structure of human TLR8 in complex with ORN06S | | 分子名称: | 1-[(2R,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1H,3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2014-07-30 | | 公開日 | 2015-01-14 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Toll-like receptor 8 senses degradation products of single-stranded RNA.
Nat.Struct.Mol.Biol., 22, 2015
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6IR4
 | | Crystal structure of BioU from Synechocystis sp.PCC6803 (apo form) | | 分子名称: | Slr0355 protein | | 著者 | Sakaki, K, Oishi, K, Shimizu, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | | 登録日 | 2018-11-10 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria.
Nat.Chem.Biol., 16, 2020
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3VLA
 | | Crystal structure of edgp | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EDGP | | 著者 | Yoshizawa, T, Shimizu, T, Hirano, H, Sato, M, Hashimoto, H. | | 登録日 | 2011-11-30 | | 公開日 | 2012-04-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor
J.Biol.Chem., 287, 2012
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3VLB
 | | Crystal structure of xeg-edgp | | 分子名称: | EDGP, Xyloglucan-specific endo-beta-1,4-glucanase A | | 著者 | Yoshizawa, T, Shimizu, T, Hirano, H, Sato, M, Hashimoto, H. | | 登録日 | 2011-11-30 | | 公開日 | 2012-04-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor
J.Biol.Chem., 287, 2012
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3VL8
 | | Crystal structure of XEG | | 分子名称: | SULFATE ION, Xyloglucan-specific endo-beta-1,4-glucanase A | | 著者 | Yoshizawa, T, Shimizu, T, Hirano, H, Sato, M, Hashimoto, H. | | 登録日 | 2011-11-30 | | 公開日 | 2012-04-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor
J.Biol.Chem., 287, 2012
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5IRM
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3VJH
 | | Human PPAR GAMMA ligand binding domain in complex with JKPL35 | | 分子名称: | (2S)-2-[4-methoxy-3-({[4-(trifluoromethyl)benzoyl]amino}methyl)benzyl]pentanoic acid, Peroxisome proliferator-activated receptor gamma | | 著者 | Tomioka, D, Kuwabara, N, Hashimoto, H, Sato, M, Shimizu, T. | | 登録日 | 2011-10-20 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
J.Med.Chem., 55, 2012
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3VJI
 | | Human PPAR gamma ligand binding domain in complex with JKPL53 | | 分子名称: | (2S)-2-{4-butoxy-3-[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]benzoyl}amino)methyl]benzyl}butanoic acid, Peroxisome proliferator-activated receptor gamma | | 著者 | Tomioka, D, Kuwabara, N, Hashimoto, H, Sato, M, Shimizu, T. | | 登録日 | 2011-10-20 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
J.Med.Chem., 55, 2012
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5IRL
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6IF5
 | | Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guanosine 2',3'-cyclic phosphate) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-PHOSPHATE-2',3'-CYCLIC PHOSPHATE, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2018-09-18 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
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1GC6
 | | CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, RADIXIN | | 著者 | Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. | | 登録日 | 2000-07-21 | | 公開日 | 2000-09-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.
EMBO J., 19, 2000
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1GC7
 | | CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN | | 分子名称: | RADIXIN | | 著者 | Hamada, K, Shimizu, T, Matsui, T, Tsukita, S, Tsukita, S, Hakoshima, T. | | 登録日 | 2000-07-21 | | 公開日 | 2000-09-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.
EMBO J., 19, 2000
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7BY1
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7WM4
 | | Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (81-MER), ... | | 著者 | Sakaniwa, K, Ohto, U, Shimizu, T. | | 登録日 | 2022-01-14 | | 公開日 | 2023-01-25 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
Nat Commun, 14, 2023
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8HRX
 | | Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex | | 分子名称: | Fab heavy chain from antibody IgG clone number YN9048, Fab light chain from antibody IgG clone number YN9048, PreS1 protein (Fragment), ... | | 著者 | Asami, J, Shimizu, T, Ohto, U. | | 登録日 | 2022-12-16 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
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8HRY
 | | Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex | | 分子名称: | Fab heavy chain from antibody IgG clone number YN9016, Fab light chain from antibody IgG clone number YN9016, Large S protein (Fragment), ... | | 著者 | Asami, J, Shimizu, T, Ohto, U. | | 登録日 | 2022-12-16 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
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1BDJ
 | | COMPLEX STRUCTURE OF HPT DOMAIN AND CHEY | | 分子名称: | AEROBIC RESPIRATION CONTROL SENSOR PROTEIN ARCB, CHEY, SULFATE ION | | 著者 | Kato, M, Mizuno, T, Shimizu, T, Hakoshima, T. | | 登録日 | 1998-05-10 | | 公開日 | 1999-05-11 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor protein ArcB complexed with the chemotaxis response regulator CheY.
Acta Crystallogr.,Sect.D, 55, 1999
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4ZLC
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4ZLD
 | | Crystal structure of human Roquin-2 ROQ domain in complex with Roquin CDE RNA | | 分子名称: | GLYCEROL, RNA (5'-R(*UP*AP*AP*CP*UP*UP*CP*UP*GP*UP*GP*AP*AP*GP*UP*UP*G)-3'), Roquin-2 | | 著者 | Sakurai, S, Ohto, U, Shimizu, T. | | 登録日 | 2015-05-01 | | 公開日 | 2015-08-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of human Roquin-2 and its complex with constitutive-decay element RNA
Acta Crystallogr.,Sect.F, 71, 2015
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5DST
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1J19
 | | Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide | | 分子名称: | 16-mer peptide from Intercellular adhesion molecule-2, radixin | | 著者 | Hamada, K, Shimizu, T, Yonemura, S, Tsukita, S, Tsukita, S, Hakoshima, T. | | 登録日 | 2002-12-02 | | 公開日 | 2003-03-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex
EMBO J., 22, 2003
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5JKC
 | | Crystal structure of human IZUMO1-JUNO complex (crystal form 1) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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5JKB
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5JKA
 | | Crystal structure of human JUNO (crystal form 1) | | 分子名称: | CHLORIDE ION, Sperm-egg fusion protein Juno, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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4QC0
 | | Crystal structure of human TLR8 in complex with XG-1-236 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine, Toll-like receptor 8, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2014-05-09 | | 公開日 | 2014-10-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
J.Med.Chem., 57, 2014
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