8JNB
 
 | | CRAF ras-binding domain chimera, ligand complex | | 分子名称: | 2-[4-[[(2S)-1-ethanoyl-3-oxidanylidene-2H-indol-2-yl]methyl]-2-methoxy-phenoxy]ethanamide, RAF proto-oncogene serine/threonine-protein kinase, CRaf | | 著者 | Kawamura, T, Kumasaka, T. | | 登録日 | 2023-06-06 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers
To Be Published
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8JNA
 | | CRAF ras-binding domain chimera, apo form | | 分子名称: | RAF proto-oncogene serine/threonine-protein kinase, CRaf | | 著者 | Kawamura, T, Kumasaka, T. | | 登録日 | 2023-06-06 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers
To Be Published
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8IG1
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6JIG
 | | Crystal structure of GMP reductase C318A from Trypanosoma brucei in complex with guanosine 5'-monophosphate | | 分子名称: | GMP reductase, GUANOSINE-5'-MONOPHOSPHATE, POTASSIUM ION | | 著者 | Mase, H, Imamura, A, Nishimura, S, Inui, T. | | 登録日 | 2019-02-21 | | 公開日 | 2020-02-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | | 主引用文献 | Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-beta-synthase domain.
Nat Commun, 11, 2020
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6JL8
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7EJQ
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7EJR
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7C7F
 | | Crystal structures of AKR1C3 binary complex with NADP+ | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Aldo-keto reductase family 1 member C3, ... | | 著者 | Irie, K, Toyooka, N, Endo, S. | | 登録日 | 2020-05-25 | | 公開日 | 2020-09-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer.
J.Med.Chem., 63, 2020
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7C7G
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7C7H
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1DZE
 | | Structure of the M Intermediate of Bacteriorhodopsin trapped at 100K | | 分子名称: | 2,3-DI-O-PHYTANLY-3-SN-GLYCERO-1-PHOSPHORYL-3'-SN-GLYCEROL-1'-PHOSPHATE, 2,3-DI-PHYTANYL-GLYCEROL, 3-PHOSPHORYL-[1,2-DI-PHYTANYL]GLYCEROL, ... | | 著者 | Takeda, K, Matsui, Y, Sato, H, Hino, T, Kanamori, E, Okumura, H, Yamane, T, Iizuka, T, Kamiya, N, Adachi, S, Kouyama, T. | | 登録日 | 2000-02-25 | | 公開日 | 2000-08-16 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of the M Intermediate of Bacteriorhodopsin: Allosteric Structural Changes Mediated by Sliding Movement of a Transmembrane Helix
J.Mol.Biol., 341, 2004
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7W9Q
 | | Crystal structure of V30M-TTR in complex with naringenin derivative-14 | | 分子名称: | (2~{R})-2-(3-chloranyl-4-oxidanyl-phenyl)-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, CALCIUM ION, Transthyretin | | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | | 登録日 | 2021-12-10 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis.
J.Med.Chem., 65, 2022
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7W9R
 | | Crystal structure of V30M-TTR in complex with naringenin derivative-18 | | 分子名称: | (2~{R})-2-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, Transthyretin | | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | | 登録日 | 2021-12-10 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis.
J.Med.Chem., 65, 2022
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1WMI
 | | Crystal structure of archaeal RelE-RelB complex from Pyrococcus horikoshii OT3 | | 分子名称: | hypothetical protein PHS013, hypothetical protein PHS014 | | 著者 | Takagi, H, Kakuta, Y, Kamachi, R, Yao, M, Tanaka, I, Kimura, M. | | 登録日 | 2004-07-09 | | 公開日 | 2005-03-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects
Nat.Struct.Mol.Biol., 12, 2005
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2QMC
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2QM6
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2Z8I
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2Z8J
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2Z8K
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