3E4A
 
 | | Human IDE-inhibitor complex at 2.6 angstrom resolution | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ACETIC ACID, HYDROXAMATE PEPTIDE II1, ... | | 著者 | Malito, E, Leissring, M.A, Choi, S, Cuny, G.D, Tang, W.J. | | 登録日 | 2008-08-11 | | 公開日 | 2009-05-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Plos One, 5, 2010
|
|
1QA5
 | |
6OJ0
 | | Cryo-EM reconstruction of Sulfolobus polyhedral virus 1 (SPV1) | | 分子名称: | Structural protein VP4, Uncharacterized protein | | 著者 | Wang, F, Liu, Y, Conway, J.F, Krupovic, M, Prangishvili, D, Egelman, E.H. | | 登録日 | 2019-04-10 | | 公開日 | 2019-10-02 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | A packing for A-form DNA in an icosahedral virus.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
1QA4
 | |
8P2E
 | | Homotypic interacting B1 fab bound to Chondroitin Sulfate A | | 分子名称: | B1 fab heavy, B1 fab light | | 著者 | Raghavan, S.S.R, Dagil, R, Wang, K.T, Salanti, A. | | 登録日 | 2023-05-16 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate.
Nat Commun, 15, 2024
|
|
7KXI
 | | Structure of XL5-ligated hRpn13 Pru domain | | 分子名称: | 2-{[(2S)-2-cyano-3-{3-[(4-methylbenzene-1-carbonyl)amino]phenyl}propanoyl]amino}benzoic acid, Proteasomal ubiquitin receptor ADRM1 | | 著者 | Lu, X, Walters, K.J. | | 登録日 | 2020-12-03 | | 公開日 | 2021-12-15 | | 最終更新日 | 2021-12-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
Nat Commun, 12, 2021
|
|
7KP6
 | | Structure of Ack1 kinase in complex with a selective inhibitor | | 分子名称: | 5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine, Activated CDC42 kinase 1, CHLORIDE ION | | 著者 | Thakur, M.K, Miller, W.T, Mahajan, N, Seeliger, M.A. | | 登録日 | 2020-11-10 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance.
Nat Commun, 13, 2022
|
|
4ORZ
 | |
2OA8
 | | Crystal Structure of mTREX1 with ssDNA | | 分子名称: | 5'-D(*GP*AP*CP*G)-3', CALCIUM ION, Three prime repair exonuclease 1 | | 著者 | de Silva, U, Hollis, T. | | 登録日 | 2006-12-15 | | 公開日 | 2007-02-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Crystal Structure of TREX1 Explains the 3' Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering.
J.Biol.Chem., 282, 2007
|
|
2IOC
 | |
7P4M
 | |
7P4Q
 | |
7P4P
 | |
6I0R
 | | Structure of quinolinate synthase in complex with 5-mercaptopyridine-2,3-dicarboxylic acid | | 分子名称: | 5-mercaptopyridine-2,3-dicarboxylic acid, FE (III) ION, HYDROSULFURIC ACID, ... | | 著者 | Volbeda, A, Fontecilla-Camps, J.C. | | 登録日 | 2018-10-26 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.
Chem.Commun.(Camb.), 55, 2019
|
|
6I0K
 | | Structure of quinolinate synthase in complex with 4-mercaptophthalic acid | | 分子名称: | 4-mercaptoidenecyclohexa-2,5-diene-1,2-dicarboxylic acid, CHLORIDE ION, IRON/SULFUR CLUSTER, ... | | 著者 | Volbeda, A, Fontecilla-Camps, J.C. | | 登録日 | 2018-10-26 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.
Chem.Commun.(Camb.), 55, 2019
|
|
8EXH
 | | Agrobacterium tumefaciens Tpilus | | 分子名称: | (14S,17R)-20-amino-17-hydroxy-11,17-dioxo-12,16,18-trioxa-17lambda~5~-phosphaicosan-14-yl tetradecanoate, Protein virB2 | | 著者 | Beltran, L.C, Egelman, E.H. | | 登録日 | 2022-10-25 | | 公開日 | 2023-03-22 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery
Nat Commun, 14, 2023
|
|
6I0P
 | | Structure of quinolinate synthase in complex with 6-mercaptopyridine-2,3-dicarboxylic acid | | 分子名称: | 6-mercaptopyridine-2,3-dicarboxylic acid, CHLORIDE ION, IRON/SULFUR CLUSTER, ... | | 著者 | Volbeda, A, Fontecilla-Camps, J.C. | | 登録日 | 2018-10-26 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.
Chem.Commun.(Camb.), 55, 2019
|
|
8DFU
 | | Cryo-EM structure of conjugation pili from Aeropyrum pernix | | 分子名称: | (2S)-3-{[(3R,7S,11S,15S)-3,7,11,15,19-pentamethylicosyl]oxy}-2-{[(2R,6S,10S,14R)-2,6,10,14,18-pentamethylnonadecyl]oxy}propyl dihydrogen phosphate, Pilin protein | | 著者 | Beltran, L.C, Egelman, E.H. | | 登録日 | 2022-06-22 | | 公開日 | 2023-03-22 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery.
Nat Commun, 14, 2023
|
|
8DFT
 | | Cryo-EM structure of conjugative pili from Pyrobaculum calidifontis | | 分子名称: | Pilin protein, [(2~{S},7~{S},11~{S},15~{S},19~{R},22~{R},26~{S},30~{R},34~{R},38~{S},43~{S},47~{S},51~{S},55~{R},58~{R},62~{S},66~{R},70~{R})-38-(hydroxymethyl)-7,11,15,19,22,26,30,34,43,47,51,55,58,62,66,70-hexadecamethyl-1,4,37,40-tetraoxacyclodoheptacont-2-yl]methanol | | 著者 | Beltran, L.C, Egelman, E.H. | | 登録日 | 2022-06-22 | | 公開日 | 2023-03-22 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery.
Nat Commun, 14, 2023
|
|
6D5F
 | | Cryo-EM reconstruction of membrane-enveloped filamentous virus SFV1 (Sulfolobus filamentous virus 1) | | 分子名称: | DNA (336-MER), Fimbrial protein | | 著者 | Wang, F, Osinski, T, Liu, Y, Krupovic, M, Prangishvili, D, Egelman, E.H. | | 登録日 | 2018-04-19 | | 公開日 | 2018-08-29 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile.
Nat Commun, 9, 2018
|
|
6T8P
 | | HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide | | 分子名称: | 1,2-ETHANEDIOL, 3,5-bis(fluoranyl)-~{N}-[5-[(2~{R})-2-(3-fluorophenyl)-3-methyl-butyl]-1,3,4-thiadiazol-2-yl]benzenesulfonamide, IODIDE ION, ... | | 著者 | Blaesse, M, Venalainen, J. | | 登録日 | 2019-10-24 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
|
|
6T8Q
 | | HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide | | 分子名称: | (2~{R})-1-[6-methyl-5-(oxan-4-yl)-7-oxidanylidene-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]-~{N}-(phenylmethyl)pyrrolidine-2-carboxamide, ACETATE ION, CADMIUM ION, ... | | 著者 | Blaesse, M, Venalainen, J. | | 登録日 | 2019-10-24 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
|
|
7NNH
 | |
7RO4
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 3 | | 分子名称: | major capsid protein | | 著者 | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | 登録日 | 2021-07-30 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
|
|
7ROI
 | | Cryo-EM reconstruction of Sulfolobus monocaudavirus SMV1, symmetry 12 | | 分子名称: | major capsid protein | | 著者 | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | | 登録日 | 2021-07-30 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.
Cell, 185, 2022
|
|
