6PL1
| TRK-A IN COMPLEX WITH LIGAND 1B | 分子名称: | High affinity nerve growth factor receptor, N-(5-{[(7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-N'-[3-(trifluoromethyl)phenyl]urea | 著者 | Subramanian, G. | 登録日 | 2019-06-30 | 公開日 | 2019-10-09 | 最終更新日 | 2019-10-30 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Lead identification and characterization of hTrkA type 2 inhibitors. Bioorg.Med.Chem.Lett., 29, 2019
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6PQ5
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6P78
| queuine lyase from Clostridium spiroforme bound to SAM and queuine | 分子名称: | 2-amino-5-({[(1S,4S,5S)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, IRON/SULFUR CLUSTER, Queuine lyase, ... | 著者 | Almo, S.C, Grove, T.L. | 登録日 | 2019-06-05 | 公開日 | 2019-09-18 | 最終更新日 | 2019-12-18 | 実験手法 | X-RAY DIFFRACTION (1.726 Å) | 主引用文献 | Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens. Proc.Natl.Acad.Sci.USA, 116, 2019
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6P6F
| BG505 SOSIP-I53-50NP | 分子名称: | I53-50A.1NT1, I53-50B.4PT1 | 著者 | Berndsen, Z.T, Ward, A.B. | 登録日 | 2019-06-03 | 公開日 | 2019-06-19 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. Nat Commun, 10, 2019
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6PHC
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6PHB
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7ZEY
| Complex Cyp33-RRM : MLL1-PHD3 | 分子名称: | MLL cleavage product N320, Peptidyl-prolyl cis-trans isomerase E, ZINC ION | 著者 | Blatter, M, Allain, F, Meylan, C. | 登録日 | 2022-03-31 | 公開日 | 2022-04-13 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
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7ZHS
| 3D reconstruction of the cylindrical assembly of DnaJA2 delta G/F by imposing D5 symmetry | 分子名称: | Ubiquitin-like protein SMT3,DnaJ homolog subfamily A member 2, ZINC ION | 著者 | Cuellar, J, Velasco-Carneros, L, Santiago, C, Martin-Benito, J, Valpuesta, J, Muga, A. | 登録日 | 2022-04-07 | 公開日 | 2023-07-26 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | 主引用文献 | The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70. Nat Commun, 14, 2023
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830C
| COLLAGENASE-3 (MMP-13) COMPLEXED TO A SULPHONE-BASED HYDROXAMIC ACID | 分子名称: | 4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE, CALCIUM ION, MMP-13, ... | 著者 | Lovejoy, B, Welch, A, Carr, S, Luong, C, Broka, C, Hendricks, R.T, Campbell, J, Walker, K, Martin, R, Van Wart, H, Browner, M.F. | 登録日 | 1998-08-06 | 公開日 | 1999-08-06 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors. Nat.Struct.Biol., 6, 1999
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5WRE
| Hepatitis B virus core protein Y132A mutant in complex with heteroaryldihydropyrimidine (HAP_R01) | 分子名称: | (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid, CHLORIDE ION, Core protein, ... | 著者 | Zhou, Z, Xu, Z.H. | 登録日 | 2016-12-01 | 公開日 | 2017-02-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.946 Å) | 主引用文献 | Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep, 7, 2017
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5WB0
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5WPI
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5W9C
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5WJ7
| Crystal Structure of Amino Acids 1733-1797 of Human Beta Cardiac Myosin Fused to Xrcc4 | 分子名称: | DNA repair protein XRCC4,Myosin-7 | 著者 | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | 登録日 | 2017-07-21 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod. J. Struct. Biol., 200, 2017
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5WKB
| MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low complexity domain of TDP-43, residues 312-317 | 分子名称: | TAR DNA-binding protein 43 | 著者 | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | 登録日 | 2017-07-24 | 公開日 | 2018-05-23 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1 Å) | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5X3S
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5XV7
| SRPK1 in complex with Alectinib | 分子名称: | 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, serine-arginine (SR) protein kinase 1 | 著者 | Zeng, C, Ngo, J.C.K. | 登録日 | 2017-06-26 | 公開日 | 2018-03-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform Cell Chem Biol, 25, 2018
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5XRT
| Crystal structure of A/Minnesota/11/2010 (H3N2) influenza virus hemagglutinin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, H, Wilson, I.A. | 登録日 | 2017-06-09 | 公開日 | 2018-07-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun, 9, 2018
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5XRS
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5XRQ
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2BCX
| Crystal structure of calmodulin in complex with a ryanodine receptor peptide | 分子名称: | CALCIUM ION, Calmodulin, Ryanodine receptor 1 | 著者 | Maximciuc, A.A, Shamoo, Y, MacKenzie, K.R. | 登録日 | 2005-10-19 | 公開日 | 2006-10-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Complex of calmodulin with a ryanodine receptor target reveals a novel, flexible binding mode. Structure, 14, 2006
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2C4F
| crystal structure of factor VII.stf complexed with pd0297121 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[6-{3-[AMINO(IMINO)METHYL]PHENOXY}-4-(DIISOPROPYLAMINO)-3,5-DIFLUOROPYRIDIN-2-YL]OXY}-5-[(ISOBUTYLAMINO)CARBONYL]BEN ZOIC ACID, CALCIUM ION, ... | 著者 | Kohrt, J.T, Zhang, E. | 登録日 | 2005-10-18 | 公開日 | 2006-10-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | The Discovery of Fluoropyridine-Based Inhibitors of the Factor Viia/Tf Complex--Part 2 Bioorg.Med.Chem.Lett., 16, 2006
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2BOZ
| Photosynthetic Reaction Center Mutant With Gly M203 Replaced With Leu | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, DECANE, ... | 著者 | Potter, J.P, Fyfe, P.K, Jones, M.R. | 登録日 | 2005-04-15 | 公開日 | 2005-05-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Strong Effects of an Individual Water Molecule on the Rate of Light-Driven Charge Separation in the Rhodobacter Sphaeroides Reaction Center. J.Biol.Chem., 280, 2005
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2RLT
| phosphorylated CPI-17 (22-120) | 分子名称: | Protein phosphatase 1 regulatory subunit 14A | 著者 | Eto, M. | 登録日 | 2007-08-11 | 公開日 | 2008-07-15 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. Structure, 15, 2007
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1N9E
| Crystal structure of Pichia pastoris Lysyl Oxidase PPLO | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Guss, J.M, Duff, A.P. | 登録日 | 2002-11-24 | 公開日 | 2004-01-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The Crystal Structure of Pichia pastoris Lysyl Oxidase Biochemistry, 42, 2003
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