8BUS
 
 | | Structure of DDB1 bound to DS59-engaged CDK12-cyclin K | | 分子名称: | 1,3-dimethyl-5-[[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]methyl]pyrazole-4-sulfonamide, Cyclin-K, Cyclin-dependent kinase 12, ... | | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | | 登録日 | 2022-11-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | | 主引用文献 | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
|
|
8BUH
 | | Structure of DDB1 bound to WX3-engaged CDK12-cyclin K | | 分子名称: | 6-[[[2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-9-propan-2-yl-purin-6-yl]amino]methyl]-3-pyridin-2-yl-1~{H}-pyridin-2-one, Cyclin-K, Cyclin-dependent kinase 12, ... | | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | | 登録日 | 2022-11-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.79 Å) | | 主引用文献 | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
|
|
8BUC
 | | Structure of DDB1 bound to dCeMM3-engaged CDK12-cyclin K | | 分子名称: | 2-(1~{H}-benzimidazol-2-ylsulfanyl)-~{N}-(5-chloranylpyridin-2-yl)ethanamide, CITRIC ACID, Cyclin-K, ... | | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | | 登録日 | 2022-11-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.85 Å) | | 主引用文献 | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
|
|
8BUT
 | | Structure of DDB1 bound to DS61-engaged CDK12-cyclin K | | 分子名称: | 2-[[6-[[4-(2-hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | | 登録日 | 2022-11-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
|
|
8BUD
 | | Structure of DDB1 bound to Z7-engaged CDK12-cyclin K | | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | | 登録日 | 2022-11-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
|
|
8BUE
 | | Structure of DDB1 bound to Z11-engaged CDK12-cyclin K | | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | | 登録日 | 2022-11-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
|
|
8BUG
 | | Structure of DDB1 bound to HQ461-engaged CDK12-cyclin K | | 分子名称: | 2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-~{N}-(5-methyl-1,3-thiazol-2-yl)ethanamide, CITRIC ACID, Cyclin-K, ... | | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | | 登録日 | 2022-11-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | | 主引用文献 | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
|
|
