6M78
 
 | | Aromatic interactions drive the coupled folding and binding of the intrinsically disordered Sesbania mosaic virus VPg protein | | 分子名称: | Polyprotein | | 著者 | Dixit, K, Karanth, N.M, Nair, S, Kumari, K, Chakraborti, K.S, Savithri, H.S, Sarma, S.P. | | 登録日 | 2020-03-17 | | 公開日 | 2021-01-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Aromatic Interactions Drive the Coupled Folding and Binding of the Intrinsically Disordered Sesbania mosaic Virus VPg Protein.
Biochemistry, 59, 2020
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6LXF
 | | Aromatic interactions drive the coupled folding and binding of the intrinsically disordered Sesbania mosaic virus VPg protein. | | 分子名称: | Polyprotein | | 著者 | Dixit, K, Karanth, N.M, Nair, S, Kumari, K, Chakrabarti, K.S, Savithri, H.S, Sarma, S.P. | | 登録日 | 2020-02-11 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Aromatic Interactions Drive the Coupled Folding and Binding of the Intrinsically Disordered Sesbania mosaic Virus VPg Protein.
Biochemistry, 59, 2020
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3FS4
 | | Crystal structure determination of Ostrich hemoglobin at 2.2 Angstrom resolution | | 分子名称: | Hemoglobin subunit alpha-A, Hemoglobin subunit beta, OXYGEN MOLECULE, ... | | 著者 | Sundaresan, S.S, Ramesh, P, Sivakumar, K, Ponnuswamy, M.N. | | 登録日 | 2009-01-09 | | 公開日 | 2009-03-31 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Structural studies of hemoglobin from two flightless birds, ostrich and turkey: insights into their differing oxygen-binding properties.
Acta Crystallogr D Struct Biol, 77, 2021
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1IL9
 | | STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 8-METHYL-9-OXOGUANINE | | 分子名称: | 5-AMINO-2-METHYL-6H-OXAZOLO[5,4-D]PYRIMIDIN-7-ONE, RICIN A CHAIN | | 著者 | Miller, D.J, Ravikumar, K, Shen, H, Suh, J.-K, Kerwin, S.M, Robertus, J.D. | | 登録日 | 2001-05-07 | | 公開日 | 2002-01-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
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1IL4
 | | STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 9-DEAZAGUANINE | | 分子名称: | 9-DEAZAGUANINE, RICIN A CHAIN | | 著者 | Miller, D.J, Ravikumar, K, Shen, H, Suh, J.-K, Kerwin, S.M, Robertus, J.D. | | 登録日 | 2001-05-07 | | 公開日 | 2002-01-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
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1IL5
 | | STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 2,5-DIAMINO-4,6-DIHYDROXYPYRIMIDINE (DDP) | | 分子名称: | 2,4-DIAMINO-4,6-DIHYDROXYPYRIMIDINE, RICIN A CHAIN | | 著者 | Miller, D.J, Ravikumar, K, Shen, H, Suh, J.-K, Kerwin, S.M, Robertus, J.D. | | 登録日 | 2001-05-07 | | 公開日 | 2002-01-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
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1IL3
 | | STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 7-DEAZAGUANINE | | 分子名称: | 7-DEAZAGUANINE, RICIN A CHAIN | | 著者 | Miller, D.J, Ravikumar, K, Shen, H, Suh, J.-K, Kerwin, S.M, Robertus, J.D. | | 登録日 | 2001-05-07 | | 公開日 | 2002-01-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
J.Med.Chem., 45, 2002
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6FOP
 | | Glycoside hydrolase family 81 from Clostridium thermocellum (CtLam81A), Mutant E515A | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... | | 著者 | Correia, M.A.S.C, Carvalho, A.L. | | 登録日 | 2018-02-08 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Novel insights into the degradation of beta-1,3-glucans by the cellulosome of Clostridium thermocellum revealed by structure and function studies of a family 81 glycoside hydrolase.
Int.J.Biol.Macromol., 117, 2018
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6UWY
 | | DYRK1A bound to a harmine derivative | | 分子名称: | 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, TETRAETHYLENE GLYCOL | | 著者 | Khamrui, S, Lazarus, M.B. | | 登録日 | 2019-11-05 | | 公開日 | 2020-02-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human beta-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor.
J.Med.Chem., 63, 2020
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4YQU
 | | Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-31 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Glutathione S-transferase omega-1, N-{5-(azepan-1-ylsulfonyl)-2-[(ethylsulfanyl)methoxy]phenyl}acetamide | | 著者 | Stuckey, J.A. | | 登録日 | 2015-03-13 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor.
Nat Commun, 7, 2016
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4YQM
 | | Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-27 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloro-N-[4-chloro-3-(dimethylsulfamoyl)phenyl]acetamide, Glutathione S-transferase omega-1 | | 著者 | Stuckey, J.A. | | 登録日 | 2015-03-13 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor.
Nat Commun, 7, 2016
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4YQV
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9BJK
 | | Inactive mu opioid receptor bound to Nb6, naloxone and NAM | | 分子名称: | Mu-type opioid receptor, Naloxone, Nalpha-[({(1M)-1-[5-(benzyloxy)pyridin-3-yl]naphthalen-2-yl}sulfanyl)acetyl]-3-methoxy-N,4-dimethyl-L-phenylalaninamide, ... | | 著者 | O'Brien, E.S, Wang, H, Kaavya Krishna, K, Zhang, C, Kobilka, B.K. | | 登録日 | 2024-04-25 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | A mu-opioid receptor modulator that works cooperatively with naloxone.
Nature, 631, 2024
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9BR7
 | | Crystal structure of human succinyl-CoA:glutarate-CoA transferase (SUGCT) in complex with Losartan carboxylic acid | | 分子名称: | AMMONIUM ION, SULFATE ION, Succinate--hydroxymethylglutarate CoA-transferase, ... | | 著者 | Wu, R, Lazarus, M.B. | | 登録日 | 2024-05-10 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Characterization, Structure, and Inhibition of the Human Succinyl-CoA:glutarate-CoA Transferase, a Putative Genetic Modifier of Glutaric Aciduria Type 1.
Acs Chem.Biol., 19, 2024
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9BR6
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8ABX
 | | Crystal structure of IDO1 in complex with Apoxidole-1 | | 分子名称: | Indoleamine 2,3-dioxygenase 1, O1-tert-butyl O2-ethyl O5-methyl (E,5R)-5-(1-methylindol-2-yl)-5-[(4-methylphenyl)sulfonylamino]pent-2-ene-1,2,5-tricarboxylate, O2-tert-butyl O3-ethyl O6-methyl (2S,6R)-6-(1-methylindol-2-yl)-2,5-dihydro-1H-pyridine-2,3,6-tricarboxylate, ... | | 著者 | Dotsch, L, Ziegler, S, Waldmann, H, Gasper, R. | | 登録日 | 2022-07-05 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype.
Angew.Chem.Int.Ed.Engl., 61, 2022
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1VE3
 | | Crystal structure of PH0226 protein from Pyrococcus horikoshii OT3 | | 分子名称: | S-ADENOSYLMETHIONINE, hypothetical protein PH0226 | | 著者 | Lokanath, N.K, Yamamoto, H, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2004-03-26 | | 公開日 | 2005-05-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of SAM-dependent methyltransferase from Pyrococcus horikoshii.
Acta Crystallogr.,Sect.F, 73, 2017
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6WPW
 | | GCGR-Gs signaling complex bound to a designed glucagon derivative | | 分子名称: | Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Hilger, D, Krishna Kumar, K, Hu, H, Mathiesen, J.M, Skiniotis, G, Kobilka, B.K. | | 登録日 | 2020-04-28 | | 公開日 | 2020-08-12 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insights into differences in G protein activation by family A and family B GPCRs.
Science, 369, 2020
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3S48
 | | Human Alpha-Haemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus | | 分子名称: | Hemoglobin subunit alpha, Iron-regulated surface determinant protein H, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Kumar, K.K, Jacques, D.A, Caradoc-Davies, T.T, Guss, J.M, Gell, D.A. | | 登録日 | 2011-05-19 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | The structure of alpha-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive alpha-haemoglobin dimerization interface
ACTA CRYSTALLOGR.,SECT.F, 70, 2014
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3SZK
 | | Crystal Structure of Human metHaemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus | | 分子名称: | Hemoglobin subunit alpha, Hemoglobin subunit beta, Iron-regulated surface determinant protein H, ... | | 著者 | Jacques, D.A, Kumar, K.K, Guss, J.M, Gell, D.A. | | 登録日 | 2011-07-19 | | 公開日 | 2011-09-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH
J.Biol.Chem., 286, 2011
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4QDM
 | | Crystal structure of N-terminal mutant (V1L) of an alkali thermostable GH10 xylanase from Bacillus sp. NG-27 | | 分子名称: | Alkaline thermostable endoxylanase, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Mahanta, P, Bhardwaj, A, Reddy, V.S, Ramakumar, S. | | 登録日 | 2014-05-14 | | 公開日 | 2015-05-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.964 Å) | | 主引用文献 | Structural insights into N-terminal to C-terminal interactions and implications for thermostability of a (beta/alpha)8-triosephosphate isomerase barrel enzyme
Febs J., 282, 2015
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4QCE
 | | Crystal structure of recombinant alkali thermostable GH10 xylanase from Bacillus sp. NG-27 | | 分子名称: | Alkaline thermostable endoxylanase, MAGNESIUM ION, SODIUM ION | | 著者 | Mahanta, P, Bhardwaj, A, Reddy, V.S, Ramakumar, S. | | 登録日 | 2014-05-11 | | 公開日 | 2015-05-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Structural insights into N-terminal to C-terminal interactions and implications for thermostability of a (beta/alpha)8-triosephosphate isomerase barrel enzyme
Febs J., 282, 2015
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4QCF
 | | Crystal structure of N-terminal mutant (V1A) of an alkali thermostable GH10 xylanase from Bacillus sp. NG-27 | | 分子名称: | Alkaline thermostable endoxylanase, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Mahanta, P, Bhardwaj, A, Reddy, V.S, Ramakumar, S. | | 登録日 | 2014-05-11 | | 公開日 | 2015-05-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Structural insights into N-terminal to C-terminal interactions and implications for thermostability of a (beta/alpha)8-triosephosphate isomerase barrel enzyme
Febs J., 282, 2015
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4RVT
 | | MAP4K4 in complex with a pyridin-2(1H)-one derivative | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-hexanoyl-4-hydroxy-5-(4-hydroxyphenyl)pyridin-2(1H)-one, Mitogen-activated protein kinase kinase kinase kinase 4 | | 著者 | Richters, A, Becker, C, Kleine, S, Rauh, D. | | 登録日 | 2014-11-27 | | 公開日 | 2015-05-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4.
Angew.Chem.Int.Ed.Engl., 54, 2015
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6OSA
 | | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state) | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. | | 登録日 | 2019-05-01 | | 公開日 | 2019-07-10 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 572, 2019
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