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6QCX
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BU of 6qcx by Molmil
Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer
分子名称: MAGNESIUM ION, PHOSPHATE ION, PYROPHOSPHATE 2-, ...
著者Cusack, S, Drncova, P.
登録日2018-12-31
公開日2019-06-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCV
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BU of 6qcv by Molmil
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP
分子名称: CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Cusack, S, Drncova, P.
登録日2018-12-31
公開日2019-06-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCT
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BU of 6qct by Molmil
Influenza B polymerase elongation complex
分子名称: 3 end, 5 end, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2018-12-30
公開日2019-06-05
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
8BDR
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BU of 8bdr by Molmil
Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-10-19
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BE0
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BU of 8be0 by Molmil
Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-10-20
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.34 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BEK
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BU of 8bek by Molmil
Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-10-21
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BF5
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BU of 8bf5 by Molmil
Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-10-24
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
6QCW
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BU of 6qcw by Molmil
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Cusack, S, Drncova, P.
登録日2018-12-31
公開日2019-06-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCS
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BU of 6qcs by Molmil
Influenza B polymerase pre-initiation complex
分子名称: 3 end, 5 end, Capped RNA, ...
著者Cusack, S, Kouba, T.
登録日2018-12-30
公開日2019-06-05
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
1ADJ
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BU of 1adj by Molmil
HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDINE
分子名称: HISTIDINE, HISTIDYL-TRNA SYNTHETASE, SULFATE ION
著者Cusack, S, Aberg, A.
登録日1997-02-18
公開日1997-08-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Biochemistry, 36, 1997
1ADY
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BU of 1ady by Molmil
HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDYL-ADENYLATE
分子名称: HISTIDYL-ADENOSINE MONOPHOSPHATE, HISTIDYL-TRNA SYNTHETASE, SULFATE ION
著者Cusack, S, Aberg, A.
登録日1997-02-19
公開日1997-08-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Biochemistry, 36, 1997
5MSG
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BU of 5msg by Molmil
Influenza B polymerase bound to vRNA promoter and capped RNA primer
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Cusack, S, Guilligay, D.
登録日2017-01-04
公開日2017-02-08
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase.
Nucleic Acids Res., 45, 2017
6EUX
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BU of 6eux by Molmil
Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
分子名称: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
著者Cusack, S, Gaudon, S.
登録日2017-10-31
公開日2017-12-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUV
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BU of 6euv by Molmil
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
分子名称: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2
著者Cusack, S, Lethier, M.
登録日2017-10-31
公開日2017-12-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUY
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BU of 6euy by Molmil
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
分子名称: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION
著者Cusack, S, Gaudon, S.
登録日2017-10-31
公開日2017-12-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUW
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BU of 6euw by Molmil
Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
分子名称: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2
著者Cusack, S, Gaudon, S.
登録日2017-10-31
公開日2017-12-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
5OOB
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BU of 5oob by Molmil
COMPLEX OF HUMAN NUCLEAR CAP-BINDING COMPLEX WITH M7GTP AND NELF-E C-TERMINAL PEPTIDE
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Negative elongation factor E, Nuclear cap-binding protein subunit 1, ...
著者Cusack, S, Schulze, W.M.
登録日2017-08-07
公開日2017-11-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.
Nat Commun, 8, 2017
5OO6
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BU of 5oo6 by Molmil
Complex of human nuclear cap-binding complex with ARS2 C-terminal peptide
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ...
著者Cusack, S, Schulze, W.M.
登録日2017-08-06
公開日2017-11-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.
Nat Commun, 8, 2017
2BYT
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BU of 2byt by Molmil
Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation
分子名称: LEUCINE, LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, ...
著者Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S.
登録日2005-08-04
公開日2005-09-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
6FSB
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BU of 6fsb by Molmil
Influenza B/Memphis/13/03 endonuclease with I38T mutation
分子名称: MAGNESIUM ION, MANGANESE (II) ION, Polymerase acidic protein
著者Cusack, S, Speranzini, V.
登録日2018-02-19
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS8
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BU of 6fs8 by Molmil
Influenza B/Memphis/13/03 endonuclease with bound inhibitor, baloxavir acid (BXA)
分子名称: Baloxavir acid, MANGANESE (II) ION, Polymerase acidic protein
著者Cusack, S, Speranzini, V.
登録日2018-02-19
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
5JCH
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BU of 5jch by Molmil
Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.95 A resolution (untwinned).
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Melanoma differentiation associated protein-5, ...
著者Cusack, S, Uchikawa, E.
登録日2016-04-15
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Mol.Cell, 62, 2016
1H4V
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BU of 1h4v by Molmil
HISTIDYL-TRNA SYNTHETASE from Thermus Thermophilus (ligand free)
分子名称: HISTIDYL-TRNA SYNTHETASE, SULFATE ION
著者Cusack, S, Yaremchuk, A, Tukalo, M.
登録日2001-05-14
公開日2001-06-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
5JAJ
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BU of 5jaj by Molmil
Structure of chicken LGP2 witha 5'p 10-mer dsRNA and ADP-AlF4-Mg.
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, LGP2, ...
著者Cusack, S, Uchikawa, E.
登録日2016-04-12
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Mol.Cell, 62, 2016
5JB2
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BU of 5jb2 by Molmil
Crystal structure of chicken LGP2 with 5'ppp 10-mer dsRNA and ADP-AlF4-Mg2+ at 2.2 A resolution.
分子名称: ADENOSINE-5'-DIPHOSPHATE, LGP2, MAGNESIUM ION, ...
著者Cusack, S, Uchikawa, E.
登録日2016-04-13
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Mol.Cell, 62, 2016

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