1A38
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![BU of 1a38 by Molmil](/molmil-images/mine/1a38) | 14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE | Descriptor: | 14-3-3 PROTEIN ZETA, R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP) | Authors: | Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. | Deposit date: | 1998-01-28 | Release date: | 1999-03-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
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1A37
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![BU of 1a37 by Molmil](/molmil-images/mine/1a37) | 14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE | Descriptor: | 14-3-3 PROTEIN ZETA, PS-RAF259 PEPTIDE LSQRQRST(SEP)TPNVHM | Authors: | Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. | Deposit date: | 1998-01-28 | Release date: | 1999-03-02 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
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2C9L
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![BU of 2c9l by Molmil](/molmil-images/mine/2c9l) | Structure of the Epstein-Barr virus ZEBRA protein | Descriptor: | 5'-D(*AP*AP*GP*CP*AP*CP*TP*GP*AP*CP *TP*CP*AP*TP*GP*AP*AP*GP*T)-3', 5'-D(*AP*CP*TP*TP*CP*AP*CP*TP*GP*AP *GP*TP*CP*AP*GP*TP*GP*CP*T)-3', BZLF1 TRANS-ACTIVATOR PROTEIN | Authors: | Petosa, C, Morand, P, Baudin, F, Moulin, M, Artero, J.B, Muller, C.W. | Deposit date: | 2005-12-13 | Release date: | 2006-02-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural Basis of Lytic Cycle Activation by the Epstein-Barr Virus Zebra Protein Mol.Cell, 21, 2006
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2C9N
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![BU of 2c9n by Molmil](/molmil-images/mine/2c9n) | Structure of the Epstein-Barr virus ZEBRA protein at approximately 3. 5 Angstrom resolution | Descriptor: | 5'-D(*CP*AP*CP*TP*GP*AP*CP*TP*CP*AP *T)-3', 5'-D(*CP*AP*TP*GP*AP*GP*TP*CP*AP*GP *T)-3', BZLF1 TRANS-ACTIVATOR PROTEIN | Authors: | Petosa, C, Morand, P, Baudin, F, Moulin, M, Artero, J.B, Muller, C.W. | Deposit date: | 2005-12-13 | Release date: | 2006-02-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural Basis of Lytic Cycle Activation by the Epstein-Barr Virus Zebra Protein Mol.Cell, 21, 2006
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1W9C
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![BU of 1w9c by Molmil](/molmil-images/mine/1w9c) | Proteolytic fragment of CRM1 spanning six C-terminal HEAT repeats | Descriptor: | CRM1 PROTEIN | Authors: | Petosa, C, Schoehn, G, Askjaer, P, Bauer, U, Moulin, M, Steuerwald, U, Soler-Lopez, M, Baudin, F, Mattaj, I.W, Muller, C.W. | Deposit date: | 2004-10-08 | Release date: | 2004-12-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Architecture of Crm1-Exportin 1 Suggests How Cooperativity is Achieved During Formation of a Nuclear Export Complex Mol.Cell, 16, 2004
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1ACC
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![BU of 1acc by Molmil](/molmil-images/mine/1acc) | ANTHRAX PROTECTIVE ANTIGEN | Descriptor: | ANTHRAX PROTECTIVE ANTIGEN, CALCIUM ION | Authors: | Petosa, C, Liddington, R.C. | Deposit date: | 1997-02-05 | Release date: | 1998-02-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the anthrax toxin protective antigen. Nature, 385, 1997
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7NX5
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![BU of 7nx5 by Molmil](/molmil-images/mine/7nx5) | |
2PYO
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![BU of 2pyo by Molmil](/molmil-images/mine/2pyo) | Drosophila nucleosome core | Descriptor: | CHLORIDE ION, DNA (147-MER), Histone H2A, ... | Authors: | Clapier, C.R, Petosa, C, Mueller, C.W. | Deposit date: | 2007-05-16 | Release date: | 2007-11-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structure of the Drosophila nucleosome core particle highlights evolutionary constraints on the H2A-H2B histone dimer. Proteins, 71, 2007
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5LDF
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![BU of 5ldf by Molmil](/molmil-images/mine/5ldf) | |
7ZLW
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![BU of 7zlw by Molmil](/molmil-images/mine/7zlw) | NME1 in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase A | Authors: | Garcia-Saez, I, Iuso, D, Khochbin, S, Petosa, C. | Deposit date: | 2022-04-15 | Release date: | 2023-08-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet. Sci Adv, 9, 2023
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7ZL8
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![BU of 7zl8 by Molmil](/molmil-images/mine/7zl8) | NME1 in complex with succinyl-CoA | Descriptor: | Nucleoside diphosphate kinase A, SUCCINYL-COENZYME A | Authors: | Garcia-Saez, I, Iuso, D, Khochbin, S, Petosa, C. | Deposit date: | 2022-04-14 | Release date: | 2023-08-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet. Sci Adv, 9, 2023
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7ZTK
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![BU of 7ztk by Molmil](/molmil-images/mine/7ztk) | NME1 in complex with CoA | Descriptor: | COENZYME A, Nucleoside diphosphate kinase A | Authors: | Garcia-Saez, I, Iuso, D, Khochbin, S, Petosa, C. | Deposit date: | 2022-05-10 | Release date: | 2023-08-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet. Sci Adv, 9, 2023
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6TEM
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![BU of 6tem by Molmil](/molmil-images/mine/6tem) | CENP-A nucleosome core particle with 145 base pairs of the Widom 601 sequence by cryo-EM | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3-like centromeric protein A, ... | Authors: | Boopathi, R, Danev, R, Petosa, C, Bednar, J. | Deposit date: | 2019-11-12 | Release date: | 2020-04-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends. Nucleic Acids Res., 48, 2020
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6HKT
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![BU of 6hkt by Molmil](/molmil-images/mine/6hkt) | Structure of an H1-bound 6-nucleosome array | Descriptor: | DNA (1122-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Garcia-Saez, I, Dimitrov, S, Petosa, C. | Deposit date: | 2018-09-08 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (9.7 Å) | Cite: | Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation. Mol. Cell, 72, 2018
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4BSN
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![BU of 4bsn by Molmil](/molmil-images/mine/4bsn) | Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal helical extension at 4.1A | Descriptor: | EXPORTIN-1 | Authors: | Dian, C, Bernaudat, F, Langer, K, Oliva, M.F, Fornerod, M, Schoehn, G, Muller, C.W, Petosa, C. | Deposit date: | 2013-06-11 | Release date: | 2013-07-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structure of a Truncation Mutant of the Nuclear Export Factor Crm1 Provides Insights Into the Auto-Inhibitory Role of its C-Terminal Helix. Structure, 21, 2013
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4BSM
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![BU of 4bsm by Molmil](/molmil-images/mine/4bsm) | Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal helical extension at 4.5A | Descriptor: | EXPORTIN-1 | Authors: | Dian, C, Bernaudat, F, Langer, K, Oliva, M.F, Fornerod, M, Schoehn, G, Muller, C.W, Petosa, C. | Deposit date: | 2013-06-10 | Release date: | 2013-07-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.5 Å) | Cite: | Structure of a Truncation Mutant of the Nuclear Export Factor Crm1 Provides Insights Into the Auto-Inhibitory Role of its C-Terminal Helix. Structure, 21, 2013
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2Y8G
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![BU of 2y8g by Molmil](/molmil-images/mine/2y8g) | Structure of the Ran-binding domain from human RanBP3 (E352A-R353V double mutant) | Descriptor: | RAN-BINDING PROTEIN 3, SULFATE ION | Authors: | Langer, K, Dian, C, Rybin, V, Muller, C.W, Petosa, C. | Deposit date: | 2011-02-06 | Release date: | 2011-02-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Insights Into the Function of the Crm1 Cofactor Ranbp3 from the Structure of its Ran-Binding Domain Plos One, 6, 2011
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2Y8F
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![BU of 2y8f by Molmil](/molmil-images/mine/2y8f) | Structure of the Ran-binding domain from human RanBP3 (wild type) | Descriptor: | CHLORIDE ION, GLYCEROL, RAN-BINDING PROTEIN 3 | Authors: | Langer, K, Dian, C, Rybin, V, Muller, C.W, Petosa, C. | Deposit date: | 2011-02-06 | Release date: | 2011-02-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Insights Into the Function of the Crm1 Cofactor Ranbp3 from the Structure of its Ran-Binding Domain Plos One, 6, 2011
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1UUR
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![BU of 1uur by Molmil](/molmil-images/mine/1uur) | Structure of an activated Dictyostelium STAT in its DNA-unbound form | Descriptor: | STATA PROTEIN | Authors: | Soler-Lopez, M, Petosa, C, Fukuzawa, M, Ravelli, R, Williams, J.G, Muller, C.W. | Deposit date: | 2004-01-09 | Release date: | 2004-03-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of an Activated Dictyostelium Stat in its DNA-Unbound Form Mol.Cell, 13, 2004
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1UUS
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![BU of 1uus by Molmil](/molmil-images/mine/1uus) | Structure of an activated Dictyostelium STAT in its DNA-unbound form | Descriptor: | STAT PROTEIN | Authors: | Soler-Lopez, M, Petosa, C, Fukuzawa, M, Ravelli, R, Williams, J.G, Muller, C.W. | Deposit date: | 2004-01-09 | Release date: | 2004-03-26 | Last modified: | 2019-10-09 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of an Activated Dictyostelium Stat in its DNA-Unbound Form Mol.Cell, 13, 2004
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5N16
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![BU of 5n16 by Molmil](/molmil-images/mine/5n16) | First Bromodomain (BD1) from Candida albicans Bdf1 bound to a dibenzothiazepinone (compound 1) | Descriptor: | 5-cyclopropyl-2-(5-pyrazin-2-yl-1,2,4-oxadiazol-3-yl)benzo[b][1,4]benzothiazepin-6-one, Bromodomain-containing factor 1, GLYCEROL, ... | Authors: | Mietton, F, Ferri, E, Champleboux, M, Zala, N, Maubon, D, Zhou, Y, Harbut, M, Spittler, D, Garnaud, C, Courcon, M, Chauvel, M, d'Enfert, C, Kashemirov, B.A, Hull, M, Cornet, M, McKenna, C.E, Govin, J, Petosa, C. | Deposit date: | 2017-02-05 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Nat Commun, 8, 2017
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5N13
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![BU of 5n13 by Molmil](/molmil-images/mine/5n13) | Second Bromodomain (BD2) from Candida albicans Bdf1 in the unbound form | Descriptor: | Bromodomain-containing factor 1, GLYCEROL | Authors: | Mietton, F, Ferri, E, Champlebouxm, M, Zala, N, Maubon, D, Zhou, Y, Harbut, M, Spittler, D, Garnaud, C, Courcon, M, Chauvel, M, d'Enfert, C, Kashemirov, B.A, Hull, M, Cornet, M, McKenna, C.E, Govin, J, Petosa, C. | Deposit date: | 2017-02-04 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Nat Commun, 8, 2017
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5N17
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![BU of 5n17 by Molmil](/molmil-images/mine/5n17) | First Bromodomain (BD1) from Candida albicans Bdf1 bound to a dibenzothiazepinone (compound 3) | Descriptor: | (2~{S})-~{N}-(5-methyl-6-oxidanylidene-benzo[b][1,4]benzothiazepin-2-yl)oxolane-2-carboxamide, Bromodomain-containing factor 1, SULFATE ION | Authors: | Mietton, F, Ferri, E, Champleboux, M, Zala, N, Maubon, D, Zhou, Y, Harbut, M, Spittler, D, Garnaud, C, Courcon, M, Chauvon, M, d'Enfer, C, Kashemirov, B.A, Hull, M, Cornet, M, McKenna, C.E, Govin, J, Petosa, C. | Deposit date: | 2017-02-05 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Nat Commun, 8, 2017
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5N18
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![BU of 5n18 by Molmil](/molmil-images/mine/5n18) | Second Bromodomain (BD2) from Candida albicans Bdf1 bound to an imidazopyridine (compound 2) | Descriptor: | 4-[8-methyl-3-[(4-methylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]phenol, Bromodomain-containing factor 1, GLYCEROL | Authors: | Mietton, F, Ferri, E, Champleboux, M, Zala, N, Maubon, D, Zhou, Y, Harbut, M, Spittler, D, Garnaud, C, Courcon, M, Chauvel, M, d'Enfert, C, Kashemirov, B.A, Hull, M, Cornet, M, McKenna, C.E, Govin, J, Petosa, C. | Deposit date: | 2017-02-05 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Nat Commun, 8, 2017
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5N15
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![BU of 5n15 by Molmil](/molmil-images/mine/5n15) | First Bromodomain (BD1) from Candida albicans Bdf1 in the unbound form | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bromodomain-containing factor 1, GLYCEROL, ... | Authors: | Mietton, F, Ferri, E, Champleboux, M, Zala, N, Maubon, D, Zhou, Y, Harbut, M, Spittler, D, Garnaud, C, Courcon, M, Chauvel, M, d'Enfert, C, Kashemirov, B.A, Hull, M, Cornet, M, McKenna, C.E, Govin, J, Petosa, C. | Deposit date: | 2017-02-05 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Nat Commun, 8, 2017
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