1OQE
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![BU of 1oqe by Molmil](/molmil-images/mine/1oqe) | Crystal structure of sTALL-1 with BAFF-R | Descriptor: | Tumor necrosis factor ligand superfamily member 13B, soluble form, Tumor necrosis factor receptor superfamily member 13C | Authors: | Zhang, G. | Deposit date: | 2003-03-07 | Release date: | 2003-05-13 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Ligand-receptor binding revealed by the TNF family member TALL-1. Nature, 423, 2003
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6AZR
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![BU of 6azr by Molmil](/molmil-images/mine/6azr) | Crystal structure of the T264A HK853cp-BeF3-RR468 complex | Descriptor: | Chemotaxis regulator-transmits chemoreceptor signals to flagelllar motor components CheY, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Rose, J, Zhou, P. | Deposit date: | 2017-09-11 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.628 Å) | Cite: | A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases. Nat Commun, 8, 2017
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5OID
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![BU of 5oid by Molmil](/molmil-images/mine/5oid) | Complex Trichoplax STIL-NTD:human CEP85 coiled coil domain 4 | Descriptor: | Centrosomal protein of 85 kDa, Putative uncharacterized protein | Authors: | van Breugel, M. | Deposit date: | 2017-07-18 | Release date: | 2018-04-18 | Last modified: | 2018-05-09 | Method: | X-RAY DIFFRACTION (4.6 Å) | Cite: | Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly. Nat Commun, 9, 2018
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5OI9
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![BU of 5oi9 by Molmil](/molmil-images/mine/5oi9) | Trichoplax adhaerens STIL N-terminal domain | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Putative uncharacterized protein | Authors: | van Breugel, M. | Deposit date: | 2017-07-18 | Release date: | 2018-04-18 | Last modified: | 2018-05-09 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly. Nat Commun, 9, 2018
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5OI7
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![BU of 5oi7 by Molmil](/molmil-images/mine/5oi7) | Human CEP85 - coiled coil domain 4 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Centrosomal protein of 85 kDa | Authors: | van Breugel, M. | Deposit date: | 2017-07-18 | Release date: | 2018-04-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly. Nat Commun, 9, 2018
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7CKK
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![BU of 7ckk by Molmil](/molmil-images/mine/7ckk) | Structural complex of FTO bound with Dac51 | Descriptor: | 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE | Authors: | Yang, C, Gan, J. | Deposit date: | 2020-07-17 | Release date: | 2021-07-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab., 33, 2021
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4DVF
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![BU of 4dvf by Molmil](/molmil-images/mine/4dvf) | Crystal structure of BACE1 with its inhibitor | Descriptor: | Beta-secretase 1, METHYL (2S)-1-[(2R,5S,8S,12S,13S)-2,13-DIBENZYL-12-HYDROXY-3,5-DIMETHYL-8-(2-METHYLPROPYL)-15-(3-[(METHYLSULFONYL)AMINO]-5-{[(1R)-1-PHENYLETHYL]CARBAMOYL}PHENYL)-4,7,10,15-TETRAOXO-3,6,9,14-TETRAAZAPENTADECAN-1-OYL]PYRROLIDINE-2-CARBOXYLATE | Authors: | Xu, Y.C, Chen, W.Y, Li, L, Chen, T.T. | Deposit date: | 2012-02-23 | Release date: | 2013-01-16 | Last modified: | 2021-09-15 | Method: | X-RAY DIFFRACTION (1.803 Å) | Cite: | Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem., 55, 2012
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6V9T
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![BU of 6v9t by Molmil](/molmil-images/mine/6v9t) | Tudor domain of TDRD3 in complex with a small molecule | Descriptor: | 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, Tudor domain-containing protein 3, UNKNOWN ATOM OR ION | Authors: | Li, W, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2019-12-16 | Release date: | 2019-12-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.154 Å) | Cite: | A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun, 13, 2022
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7RKA
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![BU of 7rka by Molmil](/molmil-images/mine/7rka) | |
5CNQ
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![BU of 5cnq by Molmil](/molmil-images/mine/5cnq) | Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA, Mg2+ and Mn2+ ions | Descriptor: | DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), MANGANESE (II) ION, Nuclease-like protein, ... | Authors: | Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J. | Deposit date: | 2015-07-17 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.602 Å) | Cite: | Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA. Cell Rep, 13, 2015
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5CO8
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![BU of 5co8 by Molmil](/molmil-images/mine/5co8) | Crystal structure of the Holliday junction-resolving enzyme GEN1 (WT) in complex with product DNA and Mg2+ ion | Descriptor: | DNA (31-MER), DNA (5'-D(*AP*GP*AP*CP*TP*GP*CP*AP*GP*TP*TP*GP*AP*GP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*A)-3'), ... | Authors: | Liu, Y.J, Freeman, A.D.J, Declais, A.C, Wilson, T.J, Gartner, A, Lilley, D.M.J. | Deposit date: | 2015-07-20 | Release date: | 2016-01-13 | Last modified: | 2018-11-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA. Cell Rep, 13, 2015
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5EB9
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![BU of 5eb9 by Molmil](/molmil-images/mine/5eb9) | Crystal Structure Of Chicken CD8aa Homodimer | Descriptor: | CD8 alpha chain | Authors: | Liu, Y.J, Qi, J.X, Xia, C. | Deposit date: | 2015-10-18 | Release date: | 2016-09-14 | Method: | X-RAY DIFFRACTION (2.006 Å) | Cite: | The structural basis of chicken, swine and bovine CD8 alpha alpha dimers provides insight into the co-evolution with MHC I in endotherm species. Sci Rep, 6, 2016
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5EDX
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![BU of 5edx by Molmil](/molmil-images/mine/5edx) | Crystal structure of swine CD8aa homodimer | Descriptor: | CD8 alpha antigen | Authors: | Liu, Y.J, Qi, J.X, Zhang, N.Z, Xia, C. | Deposit date: | 2015-10-22 | Release date: | 2016-09-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | The structural basis of chicken, swine and bovine CD8 alpha alpha dimers provides insight into the co-evolution with MHC I in endotherm species. Sci Rep, 6, 2016
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7DV8
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![BU of 7dv8 by Molmil](/molmil-images/mine/7dv8) | The crystal structure of rice immune receptor RGA5-HMA2. | Descriptor: | Disease resistance protein RGA5 | Authors: | Zhang, X, Liu, J.F. | Deposit date: | 2021-01-12 | Release date: | 2021-10-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.447 Å) | Cite: | A designer rice NLR immune receptor confers resistance to the rice blast fungus carrying noncorresponding avirulence effectors. Proc.Natl.Acad.Sci.USA, 118, 2021
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1KVU
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![BU of 1kvu by Molmil](/molmil-images/mine/1kvu) | UDP-GALACTOSE 4-EPIMERASE COMPLEXED WITH UDP-PHENOL | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Thoden, J.B, Gulick, A.M, Holden, H.M. | Deposit date: | 1997-03-07 | Release date: | 1998-03-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli. Biochemistry, 36, 1997
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7KDC
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![BU of 7kdc by Molmil](/molmil-images/mine/7kdc) | The complex between RhoD and the Plexin B2 RBD | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B2, ... | Authors: | Kuo, Y, Wang, Y, Zhang, x. | Deposit date: | 2020-10-08 | Release date: | 2021-07-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A putative structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation. Elife, 10, 2021
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1HSJ
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![BU of 1hsj by Molmil](/molmil-images/mine/1hsj) | SARR MBP FUSION STRUCTURE | Descriptor: | FUSION PROTEIN CONSISTING OF STAPHYLOCOCCUS ACCESSORY REGULATOR PROTEIN R AND MALTOSE BINDING PROTEIN, alpha-D-glucopyranose | Authors: | Zhang, G. | Deposit date: | 2000-12-26 | Release date: | 2001-06-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the SarR protein from Staphylococcus aureus. Proc.Natl.Acad.Sci.USA, 98, 2001
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5UY1
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![BU of 5uy1 by Molmil](/molmil-images/mine/5uy1) | X-ray crystal structure of apo Halotag | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Haloalkane dehalogenase | Authors: | Dunham, N.P, Boal, A.K. | Deposit date: | 2017-02-23 | Release date: | 2017-03-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | The Cation-pi Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification. Biochemistry, 56, 2017
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5UXZ
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![BU of 5uxz by Molmil](/molmil-images/mine/5uxz) | |
4FGX
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![BU of 4fgx by Molmil](/molmil-images/mine/4fgx) | Crystal structure of bace1 with novel inhibitor | Descriptor: | Beta-secretase 1, DI(HYDROXYETHYL)ETHER, Inhibitor (2R,5S,8S,12S,13S,16S,19S,22S)-16-(3-amino-3-oxopropyl)-2,13-dibenzyl-12,22-dihydroxy-8-isobutyl-19-isopropyl-3,5,17-trimethyl-4,7,10,15,18,21-hexaoxo-3,6,9,14,17,20-hexaazatricosan-1-oic acid, ... | Authors: | Chen, T.T, Chen, W.Y, Li, L, Xu, Y.C. | Deposit date: | 2012-06-05 | Release date: | 2013-01-16 | Last modified: | 2021-09-15 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem., 55, 2012
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8I6Y
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![BU of 8i6y by Molmil](/molmil-images/mine/8i6y) | Crystal structure of Arabidopsis thaliana LOX1 | Descriptor: | FE (III) ION, Linoleate 9S-lipoxygenase 1 | Authors: | Liu, X, Liu, L. | Deposit date: | 2023-01-30 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.26 Å) | Cite: | UV-B light signal mediates stomatal closure by activating the 9-lipoxygenase pathway To Be Published
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4OU1
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![BU of 4ou1 by Molmil](/molmil-images/mine/4ou1) | Crystal structure of a computationally designed retro-aldolase covalently bound to folding probe 1 [(6-methoxynaphthalen-2-yl)(oxiran-2-yl)methanol] | Descriptor: | (1S,2S)-1-(6-methoxynaphthalen-2-yl)propane-1,2-diol, BENZOIC ACID, PHOSPHATE ION, ... | Authors: | Bhabha, G, Zhang, X, Ekiert, D.C. | Deposit date: | 2014-02-14 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts. Proc.Natl.Acad.Sci.USA, 111, 2014
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7BWN
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![BU of 7bwn by Molmil](/molmil-images/mine/7bwn) | Crystal Structure of a Designed Protein Heterocatenane | Descriptor: | Cellular tumor antigen p53, Chimera of Green fluorescent protein and p53dim | Authors: | Liu, Y.J, Duan, Z.L, Fang, J, Zhang, F, Xiao, J.Y, Zhang, W.B. | Deposit date: | 2020-04-15 | Release date: | 2020-06-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.396 Å) | Cite: | Cellular Synthesis and X-ray Crystal Structure of a Designed Protein Heterocatenane. Angew.Chem.Int.Ed.Engl., 59, 2020
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2ODD
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![BU of 2odd by Molmil](/molmil-images/mine/2odd) | Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor | Descriptor: | Protein CBFA2T1, SMRT, ZINC ION | Authors: | Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H. | Deposit date: | 2006-12-22 | Release date: | 2007-06-19 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. Cancer Cell, 11, 2007
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2OD1
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![BU of 2od1 by Molmil](/molmil-images/mine/2od1) | Solution structure of the MYND domain from human AML1-ETO | Descriptor: | Protein CBFA2T1, ZINC ION | Authors: | Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H. | Deposit date: | 2006-12-21 | Release date: | 2007-06-19 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. Cancer Cell, 11, 2007
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