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    HEADER    TRANSPORT PROTEIN                       02-MAY-19   6OT2              
    TITLE     STRUCTURE OF THE TRPV3 K169A SENSITIZED MUTANT IN APO FORM AT 4.1 A   
    TITLE    2 RESOLUTION                                                           
    COMPND    MOL_ID: 1;                                                            
    COMPND   2 MOLECULE: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V    
    COMPND   3 MEMBER 3;                                                            
    COMPND   4 CHAIN: A, B, D, C;                                                   
    COMPND   5 SYNONYM: TRPV3, VANILLOID RECEPTOR-LIKE 3, VRL-3;                    
    COMPND   6 ENGINEERED: YES;                                                     
    COMPND   7 MUTATION: YES                                                        
    SOURCE    MOL_ID: 1;                                                            
    SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
    SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
    SOURCE   4 ORGANISM_TAXID: 9606;                                                
    SOURCE   5 GENE: TRPV3;                                                         
    SOURCE   6 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
    SOURCE   7 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
    SOURCE   8 EXPRESSION_SYSTEM_TAXID: 7108                                        
    KEYWDS    ION CHANNEL, TRP CHANNEL, TRPV CHANNEL, METAL TRANSPORT, MEMBRANE     
    KEYWDS   2 TRANSPORT, MEMBRANE PROTEIN, TRANSPORT PROTEIN                       
    EXPDTA    ELECTRON MICROSCOPY                                                   
    AUTHOR    L.ZUBCEVIC,W.F.BORSCHEL,A.L.HSU,M.J.BORGNIA,S.-Y.LEE                  
    REVDAT   1   22-MAY-19 6OT2    0                                                
    JRNL        AUTH   L.ZUBCEVIC,W.F.BORSCHEL,A.L.HSU,M.J.BORGNIA,S.Y.LEE          
    JRNL        TITL   REGULATORY SWITCH AT THE CYTOPLASMIC INTERFACE CONTROLS TRPV 
    JRNL        TITL 2 CHANNEL GATING.                                              
    JRNL        REF    ELIFE                         V.   8       2019              
    JRNL        REFN                   ESSN 2050-084X                               
    JRNL        PMID   31070581                                                     
    JRNL        DOI    10.7554/ELIFE.47746                                          
    REMARK   2                                                                      
    REMARK   2 RESOLUTION.    4.10 ANGSTROMS.                                       
    REMARK   3                                                                      
    REMARK   3 REFINEMENT.                                                          
    REMARK   3   SOFTWARE PACKAGES      : NULL                                      
    REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
    REMARK   3                                                                      
    REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
    REMARK   3   PDB ENTRY                    : NULL                                
    REMARK   3   REFINEMENT SPACE             : NULL                                
    REMARK   3   REFINEMENT PROTOCOL          : NULL                                
    REMARK   3   REFINEMENT TARGET            : NULL                                
    REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
    REMARK   3                                                                      
    REMARK   3 FITTING PROCEDURE : NULL                                             
    REMARK   3                                                                      
    REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
    REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
    REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
    REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.100                          
    REMARK   3   NUMBER OF PARTICLES               : 95184                          
    REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
    REMARK   3                                       CORRECTION                     
    REMARK   3                                                                      
    REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
    REMARK   3                                                                      
    REMARK   3 OTHER DETAILS: NULL                                                  
    REMARK   4                                                                      
    REMARK   4 6OT2 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
    REMARK 100                                                                      
    REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 03-MAY-19.                  
    REMARK 100 THE DEPOSITION ID IS D_1000241295.                                   
    REMARK 245                                                                      
    REMARK 245 EXPERIMENTAL DETAILS                                                 
    REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
    REMARK 245   SPECIMEN TYPE                  : NULL                              
    REMARK 245                                                                      
    REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
    REMARK 245   SAMPLE TYPE                    : PARTICLE                          
    REMARK 245   PARTICLE TYPE                  : POINT                             
    REMARK 245   NAME OF SAMPLE                 : HUMAN TRPV3 ION CHANNEL           
    REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 2.50                              
    REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
    REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
    REMARK 245   SAMPLE BUFFER                  : NULL                              
    REMARK 245   PH                             : 8.00                              
    REMARK 245   SAMPLE DETAILS                 : NULL                              
    REMARK 245                                                                      
    REMARK 245 DATA ACQUISITION                                                     
    REMARK 245   DATE OF EXPERIMENT                : NULL                           
    REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
    REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
    REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
    REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
    REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
    REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
    REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
    REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
    REMARK 245   NOMINAL CS                        : NULL                           
    REMARK 245   IMAGING MODE                      : OTHER                          
    REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 40.00                          
    REMARK 245   ILLUMINATION MODE                 : OTHER                          
    REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
    REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
    REMARK 245   SOURCE                            : OTHER                          
    REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
    REMARK 245   IMAGING DETAILS                   : NULL                           
    REMARK 247                                                                      
    REMARK 247 ELECTRON MICROSCOPY                                                  
    REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
    REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
    REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
    REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
    REMARK 247  OF THE STRUCTURE FACTORS.                                           
    REMARK 300                                                                      
    REMARK 300 BIOMOLECULE: 1                                                       
    REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
    REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
    REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
    REMARK 300 BURIED SURFACE AREA.                                                 
    REMARK 350                                                                      
    REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
    REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
    REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
    REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
    REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
    REMARK 350                                                                      
    REMARK 350 BIOMOLECULE: 1                                                       
    REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
    REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, D, C                            
    REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
    REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
    REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
    REMARK 465                                                                      
    REMARK 465 MISSING RESIDUES                                                     
    REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
    REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
    REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
    REMARK 465                                                                      
    REMARK 465   M RES C SSSEQI                                                     
    REMARK 465     PRO A    97                                                      
    REMARK 465     SER A    98                                                      
    REMARK 465     ASN A    99                                                      
    REMARK 465     PRO A   100                                                      
    REMARK 465     ASN A   101                                                      
    REMARK 465     SER A   102                                                      
    REMARK 465     PRO A   103                                                      
    REMARK 465     SER A   104                                                      
    REMARK 465     ALA A   105                                                      
    REMARK 465     GLN A   106                                                      
    REMARK 465     LEU A   107                                                      
    REMARK 465     ALA A   108                                                      
    REMARK 465     LYS A   109                                                      
    REMARK 465     HIS A   150                                                      
    REMARK 465     ASP A   151                                                      
    REMARK 465     GLU A   152                                                      
    REMARK 465     ASP A   153                                                      
    REMARK 465     PRO A   463                                                      
    REMARK 465     ARG A   464                                                      
    REMARK 465     GLU A   465                                                      
    REMARK 465     GLU A   466                                                      
    REMARK 465     GLU A   467                                                      
    REMARK 465     ALA A   468                                                      
    REMARK 465     ILE A   469                                                      
    REMARK 465     PRO A   470                                                      
    REMARK 465     HIS A   471                                                      
    REMARK 465     PRO A   472                                                      
    REMARK 465     LEU A   473                                                      
    REMARK 465     ALA A   474                                                      
    REMARK 465     LEU A   475                                                      
    REMARK 465     THR A   476                                                      
    REMARK 465     HIS A   477                                                      
    REMARK 465     LYS A   478                                                      
    REMARK 465     MET A   479                                                      
    REMARK 465     ARG A   509                                                      
    REMARK 465     PRO A   510                                                      
    REMARK 465     SER A   511                                                      
    REMARK 465     ASP A   512                                                      
    REMARK 465     LEU A   513                                                      
    REMARK 465     GLN A   514                                                      
    REMARK 465     SER A   515                                                      
    REMARK 465     ILE A   516                                                      
    REMARK 465     LEU A   517                                                      
    REMARK 465     GLU A   751                                                      
    REMARK 465     ASP A   752                                                      
    REMARK 465     PRO A   753                                                      
    REMARK 465     GLY A   754                                                      
    REMARK 465     PRO A   755                                                      
    REMARK 465     VAL A   756                                                      
    REMARK 465     ARG A   757                                                      
    REMARK 465     ARG A   758                                                      
    REMARK 465     THR A   759                                                      
    REMARK 465     ASP A   760                                                      
    REMARK 465     PHE A   761                                                      
    REMARK 465     ASN A   762                                                      
    REMARK 465     LYS A   763                                                      
    REMARK 465     ILE A   764                                                      
    REMARK 465     GLN A   765                                                      
    REMARK 465     ASP A   766                                                      
    REMARK 465     SER A   767                                                      
    REMARK 465     SER A   768                                                      
    REMARK 465     ARG A   769                                                      
    REMARK 465     ASN A   770                                                      
    REMARK 465     ASN A   771                                                      
    REMARK 465     SER A   772                                                      
    REMARK 465     LYS A   773                                                      
    REMARK 465     THR A   774                                                      
    REMARK 465     THR A   775                                                      
    REMARK 465     LEU A   776                                                      
    REMARK 465     ASN A   777                                                      
    REMARK 465     ALA A   778                                                      
    REMARK 465     PHE A   779                                                      
    REMARK 465     GLU A   780                                                      
    REMARK 465     GLU A   781                                                      
    REMARK 465     VAL A   782                                                      
    REMARK 465     GLU A   783                                                      
    REMARK 465     GLU A   784                                                      
    REMARK 465     PHE A   785                                                      
    REMARK 465     PRO A   786                                                      
    REMARK 465     GLU A   787                                                      
    REMARK 465     THR A   788                                                      
    REMARK 465     SER A   789                                                      
    REMARK 465     VAL A   790                                                      
    REMARK 465     VAL A   791                                                      
    REMARK 465     ASP A   792                                                      
    REMARK 465     ALA A   793                                                      
    REMARK 465     GLY A   794                                                      
    REMARK 465     LEU A   795                                                      
    REMARK 465     GLU A   796                                                      
    REMARK 465     VAL A   797                                                      
    REMARK 465     LEU A   798                                                      
    REMARK 465     PHE A   799                                                      
    REMARK 465     GLN A   800                                                      
    REMARK 465     GLY A   801                                                      
    REMARK 465     ASP A   802                                                      
    REMARK 465     TYR A   803                                                      
    REMARK 465     LYS A   804                                                      
    REMARK 465     ASP A   805                                                      
    REMARK 465     ASP A   806                                                      
    REMARK 465     ASP A   807                                                      
    REMARK 465     ASP A   808                                                      
    REMARK 465     LYS A   809                                                      
    REMARK 465     ALA A   810                                                      
    REMARK 465     HIS A   811                                                      
    REMARK 465     HIS A   812                                                      
    REMARK 465     HIS A   813                                                      
    REMARK 465     HIS A   814                                                      
    REMARK 465     HIS A   815                                                      
    REMARK 465     HIS A   816                                                      
    REMARK 465     PRO B    97                                                      
    REMARK 465     SER B    98                                                      
    REMARK 465     ASN B    99                                                      
    REMARK 465     PRO B   100                                                      
    REMARK 465     ASN B   101                                                      
    REMARK 465     SER B   102                                                      
    REMARK 465     PRO B   103                                                      
    REMARK 465     SER B   104                                                      
    REMARK 465     ALA B   105                                                      
    REMARK 465     GLN B   106                                                      
    REMARK 465     LEU B   107                                                      
    REMARK 465     ALA B   108                                                      
    REMARK 465     LYS B   109                                                      
    REMARK 465     HIS B   150                                                      
    REMARK 465     ASP B   151                                                      
    REMARK 465     GLU B   152                                                      
    REMARK 465     ASP B   153                                                      
    REMARK 465     PRO B   463                                                      
    REMARK 465     ARG B   464                                                      
    REMARK 465     GLU B   465                                                      
    REMARK 465     GLU B   466                                                      
    REMARK 465     GLU B   467                                                      
    REMARK 465     ALA B   468                                                      
    REMARK 465     ILE B   469                                                      
    REMARK 465     PRO B   470                                                      
    REMARK 465     HIS B   471                                                      
    REMARK 465     PRO B   472                                                      
    REMARK 465     LEU B   473                                                      
    REMARK 465     ALA B   474                                                      
    REMARK 465     LEU B   475                                                      
    REMARK 465     THR B   476                                                      
    REMARK 465     HIS B   477                                                      
    REMARK 465     LYS B   478                                                      
    REMARK 465     MET B   479                                                      
    REMARK 465     ARG B   509                                                      
    REMARK 465     PRO B   510                                                      
    REMARK 465     SER B   511                                                      
    REMARK 465     ASP B   512                                                      
    REMARK 465     LEU B   513                                                      
    REMARK 465     GLN B   514                                                      
    REMARK 465     SER B   515                                                      
    REMARK 465     ILE B   516                                                      
    REMARK 465     LEU B   517                                                      
    REMARK 465     GLU B   751                                                      
    REMARK 465     ASP B   752                                                      
    REMARK 465     PRO B   753                                                      
    REMARK 465     GLY B   754                                                      
    REMARK 465     PRO B   755                                                      
    REMARK 465     VAL B   756                                                      
    REMARK 465     ARG B   757                                                      
    REMARK 465     ARG B   758                                                      
    REMARK 465     THR B   759                                                      
    REMARK 465     ASP B   760                                                      
    REMARK 465     PHE B   761                                                      
    REMARK 465     ASN B   762                                                      
    REMARK 465     LYS B   763                                                      
    REMARK 465     ILE B   764                                                      
    REMARK 465     GLN B   765                                                      
    REMARK 465     ASP B   766                                                      
    REMARK 465     SER B   767                                                      
    REMARK 465     SER B   768                                                      
    REMARK 465     ARG B   769                                                      
    REMARK 465     ASN B   770                                                      
    REMARK 465     ASN B   771                                                      
    REMARK 465     SER B   772                                                      
    REMARK 465     LYS B   773                                                      
    REMARK 465     THR B   774                                                      
    REMARK 465     THR B   775                                                      
    REMARK 465     LEU B   776                                                      
    REMARK 465     ASN B   777                                                      
    REMARK 465     ALA B   778                                                      
    REMARK 465     PHE B   779                                                      
    REMARK 465     GLU B   780                                                      
    REMARK 465     GLU B   781                                                      
    REMARK 465     VAL B   782                                                      
    REMARK 465     GLU B   783                                                      
    REMARK 465     GLU B   784                                                      
    REMARK 465     PHE B   785                                                      
    REMARK 465     PRO B   786                                                      
    REMARK 465     GLU B   787                                                      
    REMARK 465     THR B   788                                                      
    REMARK 465     SER B   789                                                      
    REMARK 465     VAL B   790                                                      
    REMARK 465     VAL B   791                                                      
    REMARK 465     ASP B   792                                                      
    REMARK 465     ALA B   793                                                      
    REMARK 465     GLY B   794                                                      
    REMARK 465     LEU B   795                                                      
    REMARK 465     GLU B   796                                                      
    REMARK 465     VAL B   797                                                      
    REMARK 465     LEU B   798                                                      
    REMARK 465     PHE B   799                                                      
    REMARK 465     GLN B   800                                                      
    REMARK 465     GLY B   801                                                      
    REMARK 465     ASP B   802                                                      
    REMARK 465     TYR B   803                                                      
    REMARK 465     LYS B   804                                                      
    REMARK 465     ASP B   805                                                      
    REMARK 465     ASP B   806                                                      
    REMARK 465     ASP B   807                                                      
    REMARK 465     ASP B   808                                                      
    REMARK 465     LYS B   809                                                      
    REMARK 465     ALA B   810                                                      
    REMARK 465     HIS B   811                                                      
    REMARK 465     HIS B   812                                                      
    REMARK 465     HIS B   813                                                      
    REMARK 465     HIS B   814                                                      
    REMARK 465     HIS B   815                                                      
    REMARK 465     HIS B   816                                                      
    REMARK 465     PRO D    97                                                      
    REMARK 465     SER D    98                                                      
    REMARK 465     ASN D    99                                                      
    REMARK 465     PRO D   100                                                      
    REMARK 465     ASN D   101                                                      
    REMARK 465     SER D   102                                                      
    REMARK 465     PRO D   103                                                      
    REMARK 465     SER D   104                                                      
    REMARK 465     ALA D   105                                                      
    REMARK 465     GLN D   106                                                      
    REMARK 465     LEU D   107                                                      
    REMARK 465     ALA D   108                                                      
    REMARK 465     LYS D   109                                                      
    REMARK 465     HIS D   150                                                      
    REMARK 465     ASP D   151                                                      
    REMARK 465     GLU D   152                                                      
    REMARK 465     ASP D   153                                                      
    REMARK 465     PRO D   463                                                      
    REMARK 465     ARG D   464                                                      
    REMARK 465     GLU D   465                                                      
    REMARK 465     GLU D   466                                                      
    REMARK 465     GLU D   467                                                      
    REMARK 465     ALA D   468                                                      
    REMARK 465     ILE D   469                                                      
    REMARK 465     PRO D   470                                                      
    REMARK 465     HIS D   471                                                      
    REMARK 465     PRO D   472                                                      
    REMARK 465     LEU D   473                                                      
    REMARK 465     ALA D   474                                                      
    REMARK 465     LEU D   475                                                      
    REMARK 465     THR D   476                                                      
    REMARK 465     HIS D   477                                                      
    REMARK 465     LYS D   478                                                      
    REMARK 465     MET D   479                                                      
    REMARK 465     ARG D   509                                                      
    REMARK 465     PRO D   510                                                      
    REMARK 465     SER D   511                                                      
    REMARK 465     ASP D   512                                                      
    REMARK 465     LEU D   513                                                      
    REMARK 465     GLN D   514                                                      
    REMARK 465     SER D   515                                                      
    REMARK 465     ILE D   516                                                      
    REMARK 465     LEU D   517                                                      
    REMARK 465     GLU D   751                                                      
    REMARK 465     ASP D   752                                                      
    REMARK 465     PRO D   753                                                      
    REMARK 465     GLY D   754                                                      
    REMARK 465     PRO D   755                                                      
    REMARK 465     VAL D   756                                                      
    REMARK 465     ARG D   757                                                      
    REMARK 465     ARG D   758                                                      
    REMARK 465     THR D   759                                                      
    REMARK 465     ASP D   760                                                      
    REMARK 465     PHE D   761                                                      
    REMARK 465     ASN D   762                                                      
    REMARK 465     LYS D   763                                                      
    REMARK 465     ILE D   764                                                      
    REMARK 465     GLN D   765                                                      
    REMARK 465     ASP D   766                                                      
    REMARK 465     SER D   767                                                      
    REMARK 465     SER D   768                                                      
    REMARK 465     ARG D   769                                                      
    REMARK 465     ASN D   770                                                      
    REMARK 465     ASN D   771                                                      
    REMARK 465     SER D   772                                                      
    REMARK 465     LYS D   773                                                      
    REMARK 465     THR D   774                                                      
    REMARK 465     THR D   775                                                      
    REMARK 465     LEU D   776                                                      
    REMARK 465     ASN D   777                                                      
    REMARK 465     ALA D   778                                                      
    REMARK 465     PHE D   779                                                      
    REMARK 465     GLU D   780                                                      
    REMARK 465     GLU D   781                                                      
    REMARK 465     VAL D   782                                                      
    REMARK 465     GLU D   783                                                      
    REMARK 465     GLU D   784                                                      
    REMARK 465     PHE D   785                                                      
    REMARK 465     PRO D   786                                                      
    REMARK 465     GLU D   787                                                      
    REMARK 465     THR D   788                                                      
    REMARK 465     SER D   789                                                      
    REMARK 465     VAL D   790                                                      
    REMARK 465     VAL D   791                                                      
    REMARK 465     ASP D   792                                                      
    REMARK 465     ALA D   793                                                      
    REMARK 465     GLY D   794                                                      
    REMARK 465     LEU D   795                                                      
    REMARK 465     GLU D   796                                                      
    REMARK 465     VAL D   797                                                      
    REMARK 465     LEU D   798                                                      
    REMARK 465     PHE D   799                                                      
    REMARK 465     GLN D   800                                                      
    REMARK 465     GLY D   801                                                      
    REMARK 465     ASP D   802                                                      
    REMARK 465     TYR D   803                                                      
    REMARK 465     LYS D   804                                                      
    REMARK 465     ASP D   805                                                      
    REMARK 465     ASP D   806                                                      
    REMARK 465     ASP D   807                                                      
    REMARK 465     ASP D   808                                                      
    REMARK 465     LYS D   809                                                      
    REMARK 465     ALA D   810                                                      
    REMARK 465     HIS D   811                                                      
    REMARK 465     HIS D   812                                                      
    REMARK 465     HIS D   813                                                      
    REMARK 465     HIS D   814                                                      
    REMARK 465     HIS D   815                                                      
    REMARK 465     HIS D   816                                                      
    REMARK 465     PRO C    97                                                      
    REMARK 465     SER C    98                                                      
    REMARK 465     ASN C    99                                                      
    REMARK 465     PRO C   100                                                      
    REMARK 465     ASN C   101                                                      
    REMARK 465     SER C   102                                                      
    REMARK 465     PRO C   103                                                      
    REMARK 465     SER C   104                                                      
    REMARK 465     ALA C   105                                                      
    REMARK 465     GLN C   106                                                      
    REMARK 465     LEU C   107                                                      
    REMARK 465     ALA C   108                                                      
    REMARK 465     LYS C   109                                                      
    REMARK 465     HIS C   150                                                      
    REMARK 465     ASP C   151                                                      
    REMARK 465     GLU C   152                                                      
    REMARK 465     ASP C   153                                                      
    REMARK 465     PRO C   463                                                      
    REMARK 465     ARG C   464                                                      
    REMARK 465     GLU C   465                                                      
    REMARK 465     GLU C   466                                                      
    REMARK 465     GLU C   467                                                      
    REMARK 465     ALA C   468                                                      
    REMARK 465     ILE C   469                                                      
    REMARK 465     PRO C   470                                                      
    REMARK 465     HIS C   471                                                      
    REMARK 465     PRO C   472                                                      
    REMARK 465     LEU C   473                                                      
    REMARK 465     ALA C   474                                                      
    REMARK 465     LEU C   475                                                      
    REMARK 465     THR C   476                                                      
    REMARK 465     HIS C   477                                                      
    REMARK 465     LYS C   478                                                      
    REMARK 465     MET C   479                                                      
    REMARK 465     ARG C   509                                                      
    REMARK 465     PRO C   510                                                      
    REMARK 465     SER C   511                                                      
    REMARK 465     ASP C   512                                                      
    REMARK 465     LEU C   513                                                      
    REMARK 465     GLN C   514                                                      
    REMARK 465     SER C   515                                                      
    REMARK 465     ILE C   516                                                      
    REMARK 465     LEU C   517                                                      
    REMARK 465     GLU C   751                                                      
    REMARK 465     ASP C   752                                                      
    REMARK 465     PRO C   753                                                      
    REMARK 465     GLY C   754                                                      
    REMARK 465     PRO C   755                                                      
    REMARK 465     VAL C   756                                                      
    REMARK 465     ARG C   757                                                      
    REMARK 465     ARG C   758                                                      
    REMARK 465     THR C   759                                                      
    REMARK 465     ASP C   760                                                      
    REMARK 465     PHE C   761                                                      
    REMARK 465     ASN C   762                                                      
    REMARK 465     LYS C   763                                                      
    REMARK 465     ILE C   764                                                      
    REMARK 465     GLN C   765                                                      
    REMARK 465     ASP C   766                                                      
    REMARK 465     SER C   767                                                      
    REMARK 465     SER C   768                                                      
    REMARK 465     ARG C   769                                                      
    REMARK 465     ASN C   770                                                      
    REMARK 465     ASN C   771                                                      
    REMARK 465     SER C   772                                                      
    REMARK 465     LYS C   773                                                      
    REMARK 465     THR C   774                                                      
    REMARK 465     THR C   775                                                      
    REMARK 465     LEU C   776                                                      
    REMARK 465     ASN C   777                                                      
    REMARK 465     ALA C   778                                                      
    REMARK 465     PHE C   779                                                      
    REMARK 465     GLU C   780                                                      
    REMARK 465     GLU C   781                                                      
    REMARK 465     VAL C   782                                                      
    REMARK 465     GLU C   783                                                      
    REMARK 465     GLU C   784                                                      
    REMARK 465     PHE C   785                                                      
    REMARK 465     PRO C   786                                                      
    REMARK 465     GLU C   787                                                      
    REMARK 465     THR C   788                                                      
    REMARK 465     SER C   789                                                      
    REMARK 465     VAL C   790                                                      
    REMARK 465     VAL C   791                                                      
    REMARK 465     ASP C   792                                                      
    REMARK 465     ALA C   793                                                      
    REMARK 465     GLY C   794                                                      
    REMARK 465     LEU C   795                                                      
    REMARK 465     GLU C   796                                                      
    REMARK 465     VAL C   797                                                      
    REMARK 465     LEU C   798                                                      
    REMARK 465     PHE C   799                                                      
    REMARK 465     GLN C   800                                                      
    REMARK 465     GLY C   801                                                      
    REMARK 465     ASP C   802                                                      
    REMARK 465     TYR C   803                                                      
    REMARK 465     LYS C   804                                                      
    REMARK 465     ASP C   805                                                      
    REMARK 465     ASP C   806                                                      
    REMARK 465     ASP C   807                                                      
    REMARK 465     ASP C   808                                                      
    REMARK 465     LYS C   809                                                      
    REMARK 465     ALA C   810                                                      
    REMARK 465     HIS C   811                                                      
    REMARK 465     HIS C   812                                                      
    REMARK 465     HIS C   813                                                      
    REMARK 465     HIS C   814                                                      
    REMARK 465     HIS C   815                                                      
    REMARK 465     HIS C   816                                                      
    REMARK 470                                                                      
    REMARK 470 MISSING ATOM                                                         
    REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
    REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
    REMARK 470 I=INSERTION CODE):                                                   
    REMARK 470   M RES CSSEQI  ATOMS                                                
    REMARK 470     GLU A 110    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 111    CG   CD   OE1  OE2                                  
    REMARK 470     GLN A 112    CG   CD   OE1  NE2                                  
    REMARK 470     ARG A 113    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG A 114    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     LYS A 115    CG   CD   CE   NZ                                   
    REMARK 470     LYS A 116    CG   CD   CE   NZ                                   
    REMARK 470     ARG A 117    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG A 118    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     LEU A 119    CG   CD1  CD2                                       
    REMARK 470     LYS A 120    CG   CD   CE   NZ                                   
    REMARK 470     LYS A 121    CG   CD   CE   NZ                                   
    REMARK 470     ARG A 122    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ILE A 123    CG1  CG2  CD1                                       
    REMARK 470     VAL A 127    CG1  CG2                                            
    REMARK 470     SER A 128    OG                                                  
    REMARK 470     GLU A 129    CG   CD   OE1  OE2                                  
    REMARK 470     CYS A 131    SG                                                  
    REMARK 470     VAL A 132    CG1  CG2                                            
    REMARK 470     GLU A 133    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 134    CG   CD   OE1  OE2                                  
    REMARK 470     LEU A 135    CG   CD1  CD2                                       
    REMARK 470     VAL A 136    CG1  CG2                                            
    REMARK 470     GLU A 137    CG   CD   OE1  OE2                                  
    REMARK 470     LEU A 138    CG   CD1  CD2                                       
    REMARK 470     LEU A 139    CG   CD1  CD2                                       
    REMARK 470     VAL A 140    CG1  CG2                                            
    REMARK 470     GLU A 141    CG   CD   OE1  OE2                                  
    REMARK 470     LEU A 142    CG   CD1  CD2                                       
    REMARK 470     GLN A 143    CG   CD   OE1  NE2                                  
    REMARK 470     GLU A 144    CG   CD   OE1  OE2                                  
    REMARK 470     LEU A 145    CG   CD1  CD2                                       
    REMARK 470     CYS A 146    SG                                                  
    REMARK 470     ARG A 147    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG A 148    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG A 149    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ASP A 156    CG   OD1  OD2                                       
    REMARK 470     PHE A 157    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     MET A 159    CG   SD   CE                                        
    REMARK 470     LYS A 161    CG   CD   CE   NZ                                   
    REMARK 470     THR A 163    OG1  CG2                                            
    REMARK 470     SER A 165    OG                                                  
    REMARK 470     ASP A 166    CG   OD1  OD2                                       
    REMARK 470     THR A 167    OG1  CG2                                            
    REMARK 470     CYS A 171    SG                                                  
    REMARK 470     LYS A 174    CG   CD   CE   NZ                                   
    REMARK 470     ASN A 178    CG   OD1  ND2                                       
    REMARK 470     ILE A 179    CG1  CG2  CD1                                       
    REMARK 470     ASN A 182    CG   OD1  ND2                                       
    REMARK 470     THR A 183    OG1  CG2                                            
    REMARK 470     LYS A 184    CG   CD   CE   NZ                                   
    REMARK 470     GLU A 185    CG   CD   OE1  OE2                                  
    REMARK 470     VAL A 187    CG1  CG2                                            
    REMARK 470     ARG A 188    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     GLU A 195    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 196    CG   CD   OE1  OE2                                  
    REMARK 470     ASN A 197    CG   OD1  ND2                                       
    REMARK 470     ASP A 198    CG   OD1  OD2                                       
    REMARK 470     ILE A 199    CG1  CG2  CD1                                       
    REMARK 470     ARG A 202    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ASN A 205    CG   OD1  ND2                                       
    REMARK 470     GLU A 207    CG   CD   OE1  OE2                                  
    REMARK 470     THR A 209    OG1  CG2                                            
    REMARK 470     GLU A 210    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 211    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 214    CG   CD   OE1  OE2                                  
    REMARK 470     THR A 217    OG1  CG2                                            
    REMARK 470     GLU A 224    CG   CD   OE1  OE2                                  
    REMARK 470     ASP A 229    CG   OD1  OD2                                       
    REMARK 470     LEU A 234    CG   CD1  CD2                                       
    REMARK 470     ILE A 235    CG1  CG2  CD1                                       
    REMARK 470     ASP A 240    CG   OD1  OD2                                       
    REMARK 470     LYS A 246    CG   CD   CE   NZ                                   
    REMARK 470     LYS A 253    CG   CD   CE   NZ                                   
    REMARK 470     TYR A 254    CG   CD1  CD2  CE1  CE2  CZ   OH                    
    REMARK 470     GLN A 255    CG   CD   OE1  NE2                                  
    REMARK 470     HIS A 256    CG   ND1  CD2  CE1  NE2                             
    REMARK 470     GLU A 257    CG   CD   OE1  OE2                                  
    REMARK 470     CYS A 271    SG                                                  
    REMARK 470     GLN A 274    CG   CD   OE1  NE2                                  
    REMARK 470     GLU A 276    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 283    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 285    CG   CD   OE1  OE2                                  
    REMARK 470     GLN A 286    CG   CD   OE1  NE2                                  
    REMARK 470     ASN A 297    CG   OD1  ND2                                       
    REMARK 470     GLU A 308    CG   CD   OE1  OE2                                  
    REMARK 470     ASP A 309    CG   OD1  OD2                                       
    REMARK 470     PHE A 310    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LYS A 311    CG   CD   CE   NZ                                   
    REMARK 470     GLN A 313    CG   CD   OE1  NE2                                  
    REMARK 470     ASN A 314    CG   OD1  ND2                                       
    REMARK 470     MET A 320    CE                                                  
    REMARK 470     ASP A 322    CG   OD1  OD2                                       
    REMARK 470     MET A 323    CE                                                  
    REMARK 470     LEU A 326    CG   CD1  CD2                                       
    REMARK 470     GLU A 332    CG   CD   OE1  OE2                                  
    REMARK 470     THR A 335    OG1  CG2                                            
    REMARK 470     GLN A 346    CG   CD   OE1  NE2                                  
    REMARK 470     GLU A 355    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 364    CG   CD   OE1  OE2                                  
    REMARK 470     LYS A 366    CG   CD   CE   NZ                                   
    REMARK 470     GLU A 367    CG   CD   OE1  OE2                                  
    REMARK 470     LYS A 368    CG   CD   CE   NZ                                   
    REMARK 470     ARG A 369    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     SER A 372    OG                                                  
    REMARK 470     SER A 374    OG                                                  
    REMARK 470     ASP A 396    CG   OD1  OD2                                       
    REMARK 470     THR A 399    OG1  CG2                                            
    REMARK 470     ASP A 400    CG   OD1  OD2                                       
    REMARK 470     GLU A 405    CG   CD   OE1  OE2                                  
    REMARK 470     THR A 411    OG1  CG2                                            
    REMARK 470     ASN A 412    CG   OD1  ND2                                       
    REMARK 470     ASP A 414    CG   OD1  OD2                                       
    REMARK 470     GLU A 418    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 423    CG   CD   OE1  OE2                                  
    REMARK 470     LYS A 434    CG   CD   CE   NZ                                   
    REMARK 470     LYS A 438    CG   CD   CE   NZ                                   
    REMARK 470     PHE A 442    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     ARG A 462    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     TRP A 481    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
    REMARK 470     TRP A 481    CZ3  CH2                                            
    REMARK 470     LEU A 482    CG   CD1  CD2                                       
    REMARK 470     GLN A 483    CG   CD   OE1  NE2                                  
    REMARK 470     LEU A 484    CG   CD1  CD2                                       
    REMARK 470     LEU A 485    CG   CD1  CD2                                       
    REMARK 470     ARG A 487    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     MET A 488    CG   SD   CE                                        
    REMARK 470     PHE A 489    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU A 491    CG   CD1  CD2                                       
    REMARK 470     ILE A 492    CG1  CG2  CD1                                       
    REMARK 470     MET A 495    CG   SD   CE                                        
    REMARK 470     CYS A 496    SG                                                  
    REMARK 470     SER A 498    OG                                                  
    REMARK 470     VAL A 499    CG1  CG2                                            
    REMARK 470     LYS A 500    CE   NZ                                             
    REMARK 470     GLU A 501    CG   CD   OE1  OE2                                  
    REMARK 470     ILE A 503    CG1  CG2  CD1                                       
    REMARK 470     ILE A 505    CG1  CG2  CD1                                       
    REMARK 470     PHE A 506    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU A 507    CG   CD1  CD2                                       
    REMARK 470     LEU A 508    CG   CD1  CD2                                       
    REMARK 470     SER A 518    OG                                                  
    REMARK 470     ASP A 519    CG   OD1  OD2                                       
    REMARK 470     PHE A 524    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     ILE A 534    CD1                                                 
    REMARK 470     SER A 536    OG                                                  
    REMARK 470     VAL A 537    CG1  CG2                                            
    REMARK 470     PHE A 538    CD1  CD2  CE1  CE2  CZ                              
    REMARK 470     LEU A 541    CG   CD1  CD2                                       
    REMARK 470     PHE A 542    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     TYR A 544    CG   CD1  CD2  CE1  CE2  CZ   OH                    
    REMARK 470     LYS A 545    CG   CD   CE   NZ                                   
    REMARK 470     GLU A 546    CG   CD   OE1  OE2                                  
    REMARK 470     CYS A 550    SG                                                  
    REMARK 470     MET A 572    CG   SD   CE                                        
    REMARK 470     MET A 574    CG   SD   CE                                        
    REMARK 470     VAL A 577    CG1  CG2                                            
    REMARK 470     MET A 578    CG   SD   CE                                        
    REMARK 470     ILE A 579    CG1  CG2  CD1                                       
    REMARK 470     ILE A 583    CG1  CG2  CD1                                       
    REMARK 470     LEU A 584    CG   CD1  CD2                                       
    REMARK 470     ASP A 586    CG   OD1  OD2                                       
    REMARK 470     ILE A 609    CG1  CG2  CD1                                       
    REMARK 470     GLU A 610    CG   CD   OE1  OE2                                  
    REMARK 470     LYS A 611    CG   CD   CE   NZ                                   
    REMARK 470     CYS A 612    SG                                                  
    REMARK 470     LYS A 614    CG   CD   CE   NZ                                   
    REMARK 470     ASP A 615    CG   OD1  OD2                                       
    REMARK 470     ASN A 616    CG   OD1  ND2                                       
    REMARK 470     LYS A 617    CG   CD   CE   NZ                                   
    REMARK 470     ASP A 618    CG   OD1  OD2                                       
    REMARK 470     CYS A 619    SG                                                  
    REMARK 470     SER A 624    OG                                                  
    REMARK 470     ASP A 627    OD1  OD2                                            
    REMARK 470     ASP A 641    CG   OD1  OD2                                       
    REMARK 470     GLN A 645    CG   CD   OE1  NE2                                  
    REMARK 470     GLN A 646    CG   CD   OE1  NE2                                  
    REMARK 470     ASN A 647    CG   OD1  ND2                                       
    REMARK 470     SER A 648    OG                                                  
    REMARK 470     LYS A 649    CG   CD   CE   NZ                                   
    REMARK 470     GLU A 679    CG   CD   OE1  OE2                                  
    REMARK 470     VAL A 681    CG1  CG2                                            
    REMARK 470     GLU A 682    CG   CD   OE1  OE2                                  
    REMARK 470     ASN A 683    CG   OD1  ND2                                       
    REMARK 470     VAL A 684    CG1  CG2                                            
    REMARK 470     SER A 685    OG                                                  
    REMARK 470     GLU A 687    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 689    CG   CD   OE1  OE2                                  
    REMARK 470     ARG A 690    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     GLN A 695    CG   CD   OE1  NE2                                  
    REMARK 470     ILE A 700    CD1                                                 
    REMARK 470     GLU A 702    CG   CD   OE1  OE2                                  
    REMARK 470     GLU A 704    CG   CD   OE1  OE2                                  
    REMARK 470     LYS A 705    CD   CE   NZ                                        
    REMARK 470     MET A 706    CG   SD   CE                                        
    REMARK 470     GLU A 709    CG   CD   OE1  OE2                                  
    REMARK 470     LEU A 711    CG   CD1  CD2                                       
    REMARK 470     ARG A 714    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     MET A 717    CE                                                  
    REMARK 470     GLU A 719    CG   CD   OE1  OE2                                  
    REMARK 470     CYS A 721    SG                                                  
    REMARK 470     LYS A 722    CG   CD   CE   NZ                                   
    REMARK 470     GLU A 725    CG   CD   OE1  OE2                                  
    REMARK 470     ASP A 726    CG   OD1  OD2                                       
    REMARK 470     ASP A 727    CG   OD1  OD2                                       
    REMARK 470     GLU A 736    CG   CD   OE1  OE2                                  
    REMARK 470     LYS A 738    CG   CD   CE   NZ                                   
    REMARK 470     GLU A 741    CG   CD   OE1  OE2                                  
    REMARK 470     PHE A 748    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU A 749    CG   CD1  CD2                                       
    REMARK 470     ASN A 750    CG   OD1  ND2                                       
    REMARK 470     GLU B 110    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 111    CG   CD   OE1  OE2                                  
    REMARK 470     GLN B 112    CG   CD   OE1  NE2                                  
    REMARK 470     ARG B 113    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG B 114    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     LYS B 115    CG   CD   CE   NZ                                   
    REMARK 470     LYS B 116    CG   CD   CE   NZ                                   
    REMARK 470     ARG B 117    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG B 118    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     LEU B 119    CG   CD1  CD2                                       
    REMARK 470     LYS B 120    CG   CD   CE   NZ                                   
    REMARK 470     LYS B 121    CG   CD   CE   NZ                                   
    REMARK 470     ARG B 122    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ILE B 123    CG1  CG2  CD1                                       
    REMARK 470     VAL B 127    CG1  CG2                                            
    REMARK 470     SER B 128    OG                                                  
    REMARK 470     GLU B 129    CG   CD   OE1  OE2                                  
    REMARK 470     CYS B 131    SG                                                  
    REMARK 470     VAL B 132    CG1  CG2                                            
    REMARK 470     GLU B 133    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 134    CG   CD   OE1  OE2                                  
    REMARK 470     LEU B 135    CG   CD1  CD2                                       
    REMARK 470     VAL B 136    CG1  CG2                                            
    REMARK 470     GLU B 137    CG   CD   OE1  OE2                                  
    REMARK 470     LEU B 138    CG   CD1  CD2                                       
    REMARK 470     LEU B 139    CG   CD1  CD2                                       
    REMARK 470     VAL B 140    CG1  CG2                                            
    REMARK 470     GLU B 141    CG   CD   OE1  OE2                                  
    REMARK 470     LEU B 142    CG   CD1  CD2                                       
    REMARK 470     GLN B 143    CG   CD   OE1  NE2                                  
    REMARK 470     GLU B 144    CG   CD   OE1  OE2                                  
    REMARK 470     LEU B 145    CG   CD1  CD2                                       
    REMARK 470     CYS B 146    SG                                                  
    REMARK 470     ARG B 147    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG B 148    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG B 149    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ASP B 156    CG   OD1  OD2                                       
    REMARK 470     PHE B 157    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     MET B 159    CG   SD   CE                                        
    REMARK 470     LYS B 161    CG   CD   CE   NZ                                   
    REMARK 470     THR B 163    OG1  CG2                                            
    REMARK 470     SER B 165    OG                                                  
    REMARK 470     ASP B 166    CG   OD1  OD2                                       
    REMARK 470     THR B 167    OG1  CG2                                            
    REMARK 470     CYS B 171    SG                                                  
    REMARK 470     LYS B 174    CG   CD   CE   NZ                                   
    REMARK 470     ASN B 178    CG   OD1  ND2                                       
    REMARK 470     ILE B 179    CG1  CG2  CD1                                       
    REMARK 470     ASN B 182    CG   OD1  ND2                                       
    REMARK 470     THR B 183    OG1  CG2                                            
    REMARK 470     LYS B 184    CG   CD   CE   NZ                                   
    REMARK 470     GLU B 185    CG   CD   OE1  OE2                                  
    REMARK 470     VAL B 187    CG1  CG2                                            
    REMARK 470     ARG B 188    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     GLU B 195    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 196    CG   CD   OE1  OE2                                  
    REMARK 470     ASN B 197    CG   OD1  ND2                                       
    REMARK 470     ASP B 198    CG   OD1  OD2                                       
    REMARK 470     ILE B 199    CG1  CG2  CD1                                       
    REMARK 470     ARG B 202    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ASN B 205    CG   OD1  ND2                                       
    REMARK 470     GLU B 207    CG   CD   OE1  OE2                                  
    REMARK 470     THR B 209    OG1  CG2                                            
    REMARK 470     GLU B 210    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 211    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 214    CG   CD   OE1  OE2                                  
    REMARK 470     THR B 217    OG1  CG2                                            
    REMARK 470     GLU B 224    CG   CD   OE1  OE2                                  
    REMARK 470     ASP B 229    CG   OD1  OD2                                       
    REMARK 470     LEU B 234    CG   CD1  CD2                                       
    REMARK 470     ILE B 235    CG1  CG2  CD1                                       
    REMARK 470     ASP B 240    CG   OD1  OD2                                       
    REMARK 470     LYS B 246    CG   CD   CE   NZ                                   
    REMARK 470     LYS B 253    CG   CD   CE   NZ                                   
    REMARK 470     TYR B 254    CG   CD1  CD2  CE1  CE2  CZ   OH                    
    REMARK 470     GLN B 255    CG   CD   OE1  NE2                                  
    REMARK 470     HIS B 256    CG   ND1  CD2  CE1  NE2                             
    REMARK 470     GLU B 257    CG   CD   OE1  OE2                                  
    REMARK 470     CYS B 271    SG                                                  
    REMARK 470     GLN B 274    CG   CD   OE1  NE2                                  
    REMARK 470     GLU B 276    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 283    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 285    CG   CD   OE1  OE2                                  
    REMARK 470     GLN B 286    CG   CD   OE1  NE2                                  
    REMARK 470     ASN B 297    CG   OD1  ND2                                       
    REMARK 470     GLU B 308    CG   CD   OE1  OE2                                  
    REMARK 470     ASP B 309    CG   OD1  OD2                                       
    REMARK 470     PHE B 310    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LYS B 311    CG   CD   CE   NZ                                   
    REMARK 470     GLN B 313    CG   CD   OE1  NE2                                  
    REMARK 470     ASN B 314    CG   OD1  ND2                                       
    REMARK 470     MET B 320    CE                                                  
    REMARK 470     ASP B 322    CG   OD1  OD2                                       
    REMARK 470     MET B 323    CE                                                  
    REMARK 470     LEU B 326    CG   CD1  CD2                                       
    REMARK 470     GLU B 332    CG   CD   OE1  OE2                                  
    REMARK 470     THR B 335    OG1  CG2                                            
    REMARK 470     GLN B 346    CG   CD   OE1  NE2                                  
    REMARK 470     GLU B 355    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 364    CG   CD   OE1  OE2                                  
    REMARK 470     LYS B 366    CG   CD   CE   NZ                                   
    REMARK 470     GLU B 367    CG   CD   OE1  OE2                                  
    REMARK 470     LYS B 368    CG   CD   CE   NZ                                   
    REMARK 470     ARG B 369    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     SER B 372    OG                                                  
    REMARK 470     SER B 374    OG                                                  
    REMARK 470     ASP B 396    CG   OD1  OD2                                       
    REMARK 470     THR B 399    OG1  CG2                                            
    REMARK 470     ASP B 400    CG   OD1  OD2                                       
    REMARK 470     GLU B 405    CG   CD   OE1  OE2                                  
    REMARK 470     THR B 411    OG1  CG2                                            
    REMARK 470     ASN B 412    CG   OD1  ND2                                       
    REMARK 470     ASP B 414    CG   OD1  OD2                                       
    REMARK 470     GLU B 418    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 423    CG   CD   OE1  OE2                                  
    REMARK 470     LYS B 434    CG   CD   CE   NZ                                   
    REMARK 470     LYS B 438    CG   CD   CE   NZ                                   
    REMARK 470     PHE B 442    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     ARG B 462    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     TRP B 481    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
    REMARK 470     TRP B 481    CZ3  CH2                                            
    REMARK 470     LEU B 482    CG   CD1  CD2                                       
    REMARK 470     GLN B 483    CG   CD   OE1  NE2                                  
    REMARK 470     LEU B 484    CG   CD1  CD2                                       
    REMARK 470     LEU B 485    CG   CD1  CD2                                       
    REMARK 470     ARG B 487    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     MET B 488    CG   SD   CE                                        
    REMARK 470     PHE B 489    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU B 491    CG   CD1  CD2                                       
    REMARK 470     ILE B 492    CG1  CG2  CD1                                       
    REMARK 470     MET B 495    CG   SD   CE                                        
    REMARK 470     CYS B 496    SG                                                  
    REMARK 470     SER B 498    OG                                                  
    REMARK 470     VAL B 499    CG1  CG2                                            
    REMARK 470     LYS B 500    CE   NZ                                             
    REMARK 470     GLU B 501    CG   CD   OE1  OE2                                  
    REMARK 470     ILE B 503    CG1  CG2  CD1                                       
    REMARK 470     ILE B 505    CG1  CG2  CD1                                       
    REMARK 470     PHE B 506    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU B 507    CG   CD1  CD2                                       
    REMARK 470     LEU B 508    CG   CD1  CD2                                       
    REMARK 470     SER B 518    OG                                                  
    REMARK 470     ASP B 519    CG   OD1  OD2                                       
    REMARK 470     PHE B 524    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     ILE B 534    CD1                                                 
    REMARK 470     SER B 536    OG                                                  
    REMARK 470     VAL B 537    CG1  CG2                                            
    REMARK 470     PHE B 538    CD1  CD2  CE1  CE2  CZ                              
    REMARK 470     LEU B 541    CG   CD1  CD2                                       
    REMARK 470     PHE B 542    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     TYR B 544    CG   CD1  CD2  CE1  CE2  CZ   OH                    
    REMARK 470     LYS B 545    CG   CD   CE   NZ                                   
    REMARK 470     GLU B 546    CG   CD   OE1  OE2                                  
    REMARK 470     CYS B 550    SG                                                  
    REMARK 470     MET B 572    CG   SD   CE                                        
    REMARK 470     MET B 574    CG   SD   CE                                        
    REMARK 470     VAL B 577    CG1  CG2                                            
    REMARK 470     MET B 578    CG   SD   CE                                        
    REMARK 470     ILE B 579    CG1  CG2  CD1                                       
    REMARK 470     ILE B 583    CG1  CG2  CD1                                       
    REMARK 470     LEU B 584    CG   CD1  CD2                                       
    REMARK 470     ASP B 586    CG   OD1  OD2                                       
    REMARK 470     ILE B 609    CG1  CG2  CD1                                       
    REMARK 470     GLU B 610    CG   CD   OE1  OE2                                  
    REMARK 470     LYS B 611    CG   CD   CE   NZ                                   
    REMARK 470     CYS B 612    SG                                                  
    REMARK 470     LYS B 614    CG   CD   CE   NZ                                   
    REMARK 470     ASP B 615    CG   OD1  OD2                                       
    REMARK 470     ASN B 616    CG   OD1  ND2                                       
    REMARK 470     LYS B 617    CG   CD   CE   NZ                                   
    REMARK 470     ASP B 618    CG   OD1  OD2                                       
    REMARK 470     CYS B 619    SG                                                  
    REMARK 470     SER B 624    OG                                                  
    REMARK 470     ASP B 627    OD1  OD2                                            
    REMARK 470     ASP B 641    CG   OD1  OD2                                       
    REMARK 470     GLN B 645    CG   CD   OE1  NE2                                  
    REMARK 470     GLN B 646    CG   CD   OE1  NE2                                  
    REMARK 470     ASN B 647    CG   OD1  ND2                                       
    REMARK 470     SER B 648    OG                                                  
    REMARK 470     LYS B 649    CG   CD   CE   NZ                                   
    REMARK 470     GLU B 679    CG   CD   OE1  OE2                                  
    REMARK 470     VAL B 681    CG1  CG2                                            
    REMARK 470     GLU B 682    CG   CD   OE1  OE2                                  
    REMARK 470     ASN B 683    CG   OD1  ND2                                       
    REMARK 470     VAL B 684    CG1  CG2                                            
    REMARK 470     SER B 685    OG                                                  
    REMARK 470     GLU B 687    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 689    CG   CD   OE1  OE2                                  
    REMARK 470     ARG B 690    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     GLN B 695    CG   CD   OE1  NE2                                  
    REMARK 470     ILE B 700    CD1                                                 
    REMARK 470     GLU B 702    CG   CD   OE1  OE2                                  
    REMARK 470     GLU B 704    CG   CD   OE1  OE2                                  
    REMARK 470     LYS B 705    CD   CE   NZ                                        
    REMARK 470     MET B 706    CG   SD   CE                                        
    REMARK 470     GLU B 709    CG   CD   OE1  OE2                                  
    REMARK 470     LEU B 711    CG   CD1  CD2                                       
    REMARK 470     ARG B 714    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     MET B 717    CE                                                  
    REMARK 470     GLU B 719    CG   CD   OE1  OE2                                  
    REMARK 470     CYS B 721    SG                                                  
    REMARK 470     LYS B 722    CG   CD   CE   NZ                                   
    REMARK 470     GLU B 725    CG   CD   OE1  OE2                                  
    REMARK 470     ASP B 726    CG   OD1  OD2                                       
    REMARK 470     ASP B 727    CG   OD1  OD2                                       
    REMARK 470     GLU B 736    CG   CD   OE1  OE2                                  
    REMARK 470     LYS B 738    CG   CD   CE   NZ                                   
    REMARK 470     GLU B 741    CG   CD   OE1  OE2                                  
    REMARK 470     PHE B 748    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU B 749    CG   CD1  CD2                                       
    REMARK 470     ASN B 750    CG   OD1  ND2                                       
    REMARK 470     GLU D 110    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 111    CG   CD   OE1  OE2                                  
    REMARK 470     GLN D 112    CG   CD   OE1  NE2                                  
    REMARK 470     ARG D 113    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG D 114    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     LYS D 115    CG   CD   CE   NZ                                   
    REMARK 470     LYS D 116    CG   CD   CE   NZ                                   
    REMARK 470     ARG D 117    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG D 118    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     LEU D 119    CG   CD1  CD2                                       
    REMARK 470     LYS D 120    CG   CD   CE   NZ                                   
    REMARK 470     LYS D 121    CG   CD   CE   NZ                                   
    REMARK 470     ARG D 122    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ILE D 123    CG1  CG2  CD1                                       
    REMARK 470     VAL D 127    CG1  CG2                                            
    REMARK 470     SER D 128    OG                                                  
    REMARK 470     GLU D 129    CG   CD   OE1  OE2                                  
    REMARK 470     CYS D 131    SG                                                  
    REMARK 470     VAL D 132    CG1  CG2                                            
    REMARK 470     GLU D 133    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 134    CG   CD   OE1  OE2                                  
    REMARK 470     LEU D 135    CG   CD1  CD2                                       
    REMARK 470     VAL D 136    CG1  CG2                                            
    REMARK 470     GLU D 137    CG   CD   OE1  OE2                                  
    REMARK 470     LEU D 138    CG   CD1  CD2                                       
    REMARK 470     LEU D 139    CG   CD1  CD2                                       
    REMARK 470     VAL D 140    CG1  CG2                                            
    REMARK 470     GLU D 141    CG   CD   OE1  OE2                                  
    REMARK 470     LEU D 142    CG   CD1  CD2                                       
    REMARK 470     GLN D 143    CG   CD   OE1  NE2                                  
    REMARK 470     GLU D 144    CG   CD   OE1  OE2                                  
    REMARK 470     LEU D 145    CG   CD1  CD2                                       
    REMARK 470     CYS D 146    SG                                                  
    REMARK 470     ARG D 147    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG D 148    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG D 149    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ASP D 156    CG   OD1  OD2                                       
    REMARK 470     PHE D 157    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     MET D 159    CG   SD   CE                                        
    REMARK 470     LYS D 161    CG   CD   CE   NZ                                   
    REMARK 470     THR D 163    OG1  CG2                                            
    REMARK 470     SER D 165    OG                                                  
    REMARK 470     ASP D 166    CG   OD1  OD2                                       
    REMARK 470     THR D 167    OG1  CG2                                            
    REMARK 470     CYS D 171    SG                                                  
    REMARK 470     LYS D 174    CG   CD   CE   NZ                                   
    REMARK 470     ASN D 178    CG   OD1  ND2                                       
    REMARK 470     ILE D 179    CG1  CG2  CD1                                       
    REMARK 470     ASN D 182    CG   OD1  ND2                                       
    REMARK 470     THR D 183    OG1  CG2                                            
    REMARK 470     LYS D 184    CG   CD   CE   NZ                                   
    REMARK 470     GLU D 185    CG   CD   OE1  OE2                                  
    REMARK 470     VAL D 187    CG1  CG2                                            
    REMARK 470     ARG D 188    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     GLU D 195    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 196    CG   CD   OE1  OE2                                  
    REMARK 470     ASN D 197    CG   OD1  ND2                                       
    REMARK 470     ASP D 198    CG   OD1  OD2                                       
    REMARK 470     ILE D 199    CG1  CG2  CD1                                       
    REMARK 470     ARG D 202    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ASN D 205    CG   OD1  ND2                                       
    REMARK 470     GLU D 207    CG   CD   OE1  OE2                                  
    REMARK 470     THR D 209    OG1  CG2                                            
    REMARK 470     GLU D 210    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 211    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 214    CG   CD   OE1  OE2                                  
    REMARK 470     THR D 217    OG1  CG2                                            
    REMARK 470     GLU D 224    CG   CD   OE1  OE2                                  
    REMARK 470     ASP D 229    CG   OD1  OD2                                       
    REMARK 470     LEU D 234    CG   CD1  CD2                                       
    REMARK 470     ILE D 235    CG1  CG2  CD1                                       
    REMARK 470     ASP D 240    CG   OD1  OD2                                       
    REMARK 470     LYS D 246    CG   CD   CE   NZ                                   
    REMARK 470     LYS D 253    CG   CD   CE   NZ                                   
    REMARK 470     TYR D 254    CG   CD1  CD2  CE1  CE2  CZ   OH                    
    REMARK 470     GLN D 255    CG   CD   OE1  NE2                                  
    REMARK 470     HIS D 256    CG   ND1  CD2  CE1  NE2                             
    REMARK 470     GLU D 257    CG   CD   OE1  OE2                                  
    REMARK 470     CYS D 271    SG                                                  
    REMARK 470     GLN D 274    CG   CD   OE1  NE2                                  
    REMARK 470     GLU D 276    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 283    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 285    CG   CD   OE1  OE2                                  
    REMARK 470     GLN D 286    CG   CD   OE1  NE2                                  
    REMARK 470     ASN D 297    CG   OD1  ND2                                       
    REMARK 470     GLU D 308    CG   CD   OE1  OE2                                  
    REMARK 470     ASP D 309    CG   OD1  OD2                                       
    REMARK 470     PHE D 310    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LYS D 311    CG   CD   CE   NZ                                   
    REMARK 470     GLN D 313    CG   CD   OE1  NE2                                  
    REMARK 470     ASN D 314    CG   OD1  ND2                                       
    REMARK 470     MET D 320    CE                                                  
    REMARK 470     ASP D 322    CG   OD1  OD2                                       
    REMARK 470     MET D 323    CE                                                  
    REMARK 470     LEU D 326    CG   CD1  CD2                                       
    REMARK 470     GLU D 332    CG   CD   OE1  OE2                                  
    REMARK 470     THR D 335    OG1  CG2                                            
    REMARK 470     GLN D 346    CG   CD   OE1  NE2                                  
    REMARK 470     GLU D 355    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 364    CG   CD   OE1  OE2                                  
    REMARK 470     LYS D 366    CG   CD   CE   NZ                                   
    REMARK 470     GLU D 367    CG   CD   OE1  OE2                                  
    REMARK 470     LYS D 368    CG   CD   CE   NZ                                   
    REMARK 470     ARG D 369    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     SER D 372    OG                                                  
    REMARK 470     SER D 374    OG                                                  
    REMARK 470     ASP D 396    CG   OD1  OD2                                       
    REMARK 470     THR D 399    OG1  CG2                                            
    REMARK 470     ASP D 400    CG   OD1  OD2                                       
    REMARK 470     GLU D 405    CG   CD   OE1  OE2                                  
    REMARK 470     THR D 411    OG1  CG2                                            
    REMARK 470     ASN D 412    CG   OD1  ND2                                       
    REMARK 470     ASP D 414    CG   OD1  OD2                                       
    REMARK 470     GLU D 418    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 423    CG   CD   OE1  OE2                                  
    REMARK 470     LYS D 434    CG   CD   CE   NZ                                   
    REMARK 470     LYS D 438    CG   CD   CE   NZ                                   
    REMARK 470     PHE D 442    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     ARG D 462    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     TRP D 481    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
    REMARK 470     TRP D 481    CZ3  CH2                                            
    REMARK 470     LEU D 482    CG   CD1  CD2                                       
    REMARK 470     GLN D 483    CG   CD   OE1  NE2                                  
    REMARK 470     LEU D 484    CG   CD1  CD2                                       
    REMARK 470     LEU D 485    CG   CD1  CD2                                       
    REMARK 470     ARG D 487    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     MET D 488    CG   SD   CE                                        
    REMARK 470     PHE D 489    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU D 491    CG   CD1  CD2                                       
    REMARK 470     ILE D 492    CG1  CG2  CD1                                       
    REMARK 470     MET D 495    CG   SD   CE                                        
    REMARK 470     CYS D 496    SG                                                  
    REMARK 470     SER D 498    OG                                                  
    REMARK 470     VAL D 499    CG1  CG2                                            
    REMARK 470     LYS D 500    CE   NZ                                             
    REMARK 470     GLU D 501    CG   CD   OE1  OE2                                  
    REMARK 470     ILE D 503    CG1  CG2  CD1                                       
    REMARK 470     ILE D 505    CG1  CG2  CD1                                       
    REMARK 470     PHE D 506    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU D 507    CG   CD1  CD2                                       
    REMARK 470     LEU D 508    CG   CD1  CD2                                       
    REMARK 470     SER D 518    OG                                                  
    REMARK 470     ASP D 519    CG   OD1  OD2                                       
    REMARK 470     PHE D 524    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     ILE D 534    CD1                                                 
    REMARK 470     SER D 536    OG                                                  
    REMARK 470     VAL D 537    CG1  CG2                                            
    REMARK 470     PHE D 538    CD1  CD2  CE1  CE2  CZ                              
    REMARK 470     LEU D 541    CG   CD1  CD2                                       
    REMARK 470     PHE D 542    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     TYR D 544    CG   CD1  CD2  CE1  CE2  CZ   OH                    
    REMARK 470     LYS D 545    CG   CD   CE   NZ                                   
    REMARK 470     GLU D 546    CG   CD   OE1  OE2                                  
    REMARK 470     CYS D 550    SG                                                  
    REMARK 470     MET D 572    CG   SD   CE                                        
    REMARK 470     MET D 574    CG   SD   CE                                        
    REMARK 470     VAL D 577    CG1  CG2                                            
    REMARK 470     MET D 578    CG   SD   CE                                        
    REMARK 470     ILE D 579    CG1  CG2  CD1                                       
    REMARK 470     ILE D 583    CG1  CG2  CD1                                       
    REMARK 470     LEU D 584    CG   CD1  CD2                                       
    REMARK 470     ASP D 586    CG   OD1  OD2                                       
    REMARK 470     ILE D 609    CG1  CG2  CD1                                       
    REMARK 470     GLU D 610    CG   CD   OE1  OE2                                  
    REMARK 470     LYS D 611    CG   CD   CE   NZ                                   
    REMARK 470     CYS D 612    SG                                                  
    REMARK 470     LYS D 614    CG   CD   CE   NZ                                   
    REMARK 470     ASP D 615    CG   OD1  OD2                                       
    REMARK 470     ASN D 616    CG   OD1  ND2                                       
    REMARK 470     LYS D 617    CG   CD   CE   NZ                                   
    REMARK 470     ASP D 618    CG   OD1  OD2                                       
    REMARK 470     CYS D 619    SG                                                  
    REMARK 470     SER D 624    OG                                                  
    REMARK 470     ASP D 627    OD1  OD2                                            
    REMARK 470     ASP D 641    CG   OD1  OD2                                       
    REMARK 470     GLN D 645    CG   CD   OE1  NE2                                  
    REMARK 470     GLN D 646    CG   CD   OE1  NE2                                  
    REMARK 470     ASN D 647    CG   OD1  ND2                                       
    REMARK 470     SER D 648    OG                                                  
    REMARK 470     LYS D 649    CG   CD   CE   NZ                                   
    REMARK 470     GLU D 679    CG   CD   OE1  OE2                                  
    REMARK 470     VAL D 681    CG1  CG2                                            
    REMARK 470     GLU D 682    CG   CD   OE1  OE2                                  
    REMARK 470     ASN D 683    CG   OD1  ND2                                       
    REMARK 470     VAL D 684    CG1  CG2                                            
    REMARK 470     SER D 685    OG                                                  
    REMARK 470     GLU D 687    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 689    CG   CD   OE1  OE2                                  
    REMARK 470     ARG D 690    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     GLN D 695    CG   CD   OE1  NE2                                  
    REMARK 470     ILE D 700    CD1                                                 
    REMARK 470     GLU D 702    CG   CD   OE1  OE2                                  
    REMARK 470     GLU D 704    CG   CD   OE1  OE2                                  
    REMARK 470     LYS D 705    CD   CE   NZ                                        
    REMARK 470     MET D 706    CG   SD   CE                                        
    REMARK 470     GLU D 709    CG   CD   OE1  OE2                                  
    REMARK 470     LEU D 711    CG   CD1  CD2                                       
    REMARK 470     ARG D 714    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     MET D 717    CE                                                  
    REMARK 470     GLU D 719    CG   CD   OE1  OE2                                  
    REMARK 470     CYS D 721    SG                                                  
    REMARK 470     LYS D 722    CG   CD   CE   NZ                                   
    REMARK 470     GLU D 725    CG   CD   OE1  OE2                                  
    REMARK 470     ASP D 726    CG   OD1  OD2                                       
    REMARK 470     ASP D 727    CG   OD1  OD2                                       
    REMARK 470     GLU D 736    CG   CD   OE1  OE2                                  
    REMARK 470     LYS D 738    CG   CD   CE   NZ                                   
    REMARK 470     GLU D 741    CG   CD   OE1  OE2                                  
    REMARK 470     PHE D 748    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU D 749    CG   CD1  CD2                                       
    REMARK 470     ASN D 750    CG   OD1  ND2                                       
    REMARK 470     GLU C 110    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 111    CG   CD   OE1  OE2                                  
    REMARK 470     GLN C 112    CG   CD   OE1  NE2                                  
    REMARK 470     ARG C 113    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG C 114    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     LYS C 115    CG   CD   CE   NZ                                   
    REMARK 470     LYS C 116    CG   CD   CE   NZ                                   
    REMARK 470     ARG C 117    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG C 118    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     LEU C 119    CG   CD1  CD2                                       
    REMARK 470     LYS C 120    CG   CD   CE   NZ                                   
    REMARK 470     LYS C 121    CG   CD   CE   NZ                                   
    REMARK 470     ARG C 122    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ILE C 123    CG1  CG2  CD1                                       
    REMARK 470     VAL C 127    CG1  CG2                                            
    REMARK 470     SER C 128    OG                                                  
    REMARK 470     GLU C 129    CG   CD   OE1  OE2                                  
    REMARK 470     CYS C 131    SG                                                  
    REMARK 470     VAL C 132    CG1  CG2                                            
    REMARK 470     GLU C 133    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 134    CG   CD   OE1  OE2                                  
    REMARK 470     LEU C 135    CG   CD1  CD2                                       
    REMARK 470     VAL C 136    CG1  CG2                                            
    REMARK 470     GLU C 137    CG   CD   OE1  OE2                                  
    REMARK 470     LEU C 138    CG   CD1  CD2                                       
    REMARK 470     LEU C 139    CG   CD1  CD2                                       
    REMARK 470     VAL C 140    CG1  CG2                                            
    REMARK 470     GLU C 141    CG   CD   OE1  OE2                                  
    REMARK 470     LEU C 142    CG   CD1  CD2                                       
    REMARK 470     GLN C 143    CG   CD   OE1  NE2                                  
    REMARK 470     GLU C 144    CG   CD   OE1  OE2                                  
    REMARK 470     LEU C 145    CG   CD1  CD2                                       
    REMARK 470     CYS C 146    SG                                                  
    REMARK 470     ARG C 147    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG C 148    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ARG C 149    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ASP C 156    CG   OD1  OD2                                       
    REMARK 470     PHE C 157    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     MET C 159    CG   SD   CE                                        
    REMARK 470     LYS C 161    CG   CD   CE   NZ                                   
    REMARK 470     THR C 163    OG1  CG2                                            
    REMARK 470     SER C 165    OG                                                  
    REMARK 470     ASP C 166    CG   OD1  OD2                                       
    REMARK 470     THR C 167    OG1  CG2                                            
    REMARK 470     CYS C 171    SG                                                  
    REMARK 470     LYS C 174    CG   CD   CE   NZ                                   
    REMARK 470     ASN C 178    CG   OD1  ND2                                       
    REMARK 470     ILE C 179    CG1  CG2  CD1                                       
    REMARK 470     ASN C 182    CG   OD1  ND2                                       
    REMARK 470     THR C 183    OG1  CG2                                            
    REMARK 470     LYS C 184    CG   CD   CE   NZ                                   
    REMARK 470     GLU C 185    CG   CD   OE1  OE2                                  
    REMARK 470     VAL C 187    CG1  CG2                                            
    REMARK 470     ARG C 188    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     GLU C 195    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 196    CG   CD   OE1  OE2                                  
    REMARK 470     ASN C 197    CG   OD1  ND2                                       
    REMARK 470     ASP C 198    CG   OD1  OD2                                       
    REMARK 470     ILE C 199    CG1  CG2  CD1                                       
    REMARK 470     ARG C 202    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     ASN C 205    CG   OD1  ND2                                       
    REMARK 470     GLU C 207    CG   CD   OE1  OE2                                  
    REMARK 470     THR C 209    OG1  CG2                                            
    REMARK 470     GLU C 210    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 211    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 214    CG   CD   OE1  OE2                                  
    REMARK 470     THR C 217    OG1  CG2                                            
    REMARK 470     GLU C 224    CG   CD   OE1  OE2                                  
    REMARK 470     ASP C 229    CG   OD1  OD2                                       
    REMARK 470     LEU C 234    CG   CD1  CD2                                       
    REMARK 470     ILE C 235    CG1  CG2  CD1                                       
    REMARK 470     ASP C 240    CG   OD1  OD2                                       
    REMARK 470     LYS C 246    CG   CD   CE   NZ                                   
    REMARK 470     LYS C 253    CG   CD   CE   NZ                                   
    REMARK 470     TYR C 254    CG   CD1  CD2  CE1  CE2  CZ   OH                    
    REMARK 470     GLN C 255    CG   CD   OE1  NE2                                  
    REMARK 470     HIS C 256    CG   ND1  CD2  CE1  NE2                             
    REMARK 470     GLU C 257    CG   CD   OE1  OE2                                  
    REMARK 470     CYS C 271    SG                                                  
    REMARK 470     GLN C 274    CG   CD   OE1  NE2                                  
    REMARK 470     GLU C 276    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 283    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 285    CG   CD   OE1  OE2                                  
    REMARK 470     GLN C 286    CG   CD   OE1  NE2                                  
    REMARK 470     ASN C 297    CG   OD1  ND2                                       
    REMARK 470     GLU C 308    CG   CD   OE1  OE2                                  
    REMARK 470     ASP C 309    CG   OD1  OD2                                       
    REMARK 470     PHE C 310    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LYS C 311    CG   CD   CE   NZ                                   
    REMARK 470     GLN C 313    CG   CD   OE1  NE2                                  
    REMARK 470     ASN C 314    CG   OD1  ND2                                       
    REMARK 470     MET C 320    CE                                                  
    REMARK 470     ASP C 322    CG   OD1  OD2                                       
    REMARK 470     MET C 323    CE                                                  
    REMARK 470     LEU C 326    CG   CD1  CD2                                       
    REMARK 470     GLU C 332    CG   CD   OE1  OE2                                  
    REMARK 470     THR C 335    OG1  CG2                                            
    REMARK 470     GLN C 346    CG   CD   OE1  NE2                                  
    REMARK 470     GLU C 355    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 364    CG   CD   OE1  OE2                                  
    REMARK 470     LYS C 366    CG   CD   CE   NZ                                   
    REMARK 470     GLU C 367    CG   CD   OE1  OE2                                  
    REMARK 470     LYS C 368    CG   CD   CE   NZ                                   
    REMARK 470     ARG C 369    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     SER C 372    OG                                                  
    REMARK 470     SER C 374    OG                                                  
    REMARK 470     ASP C 396    CG   OD1  OD2                                       
    REMARK 470     THR C 399    OG1  CG2                                            
    REMARK 470     ASP C 400    CG   OD1  OD2                                       
    REMARK 470     GLU C 405    CG   CD   OE1  OE2                                  
    REMARK 470     THR C 411    OG1  CG2                                            
    REMARK 470     ASN C 412    CG   OD1  ND2                                       
    REMARK 470     ASP C 414    CG   OD1  OD2                                       
    REMARK 470     GLU C 418    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 423    CG   CD   OE1  OE2                                  
    REMARK 470     LYS C 434    CG   CD   CE   NZ                                   
    REMARK 470     LYS C 438    CG   CD   CE   NZ                                   
    REMARK 470     PHE C 442    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     ARG C 462    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     TRP C 481    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
    REMARK 470     TRP C 481    CZ3  CH2                                            
    REMARK 470     LEU C 482    CG   CD1  CD2                                       
    REMARK 470     GLN C 483    CG   CD   OE1  NE2                                  
    REMARK 470     LEU C 484    CG   CD1  CD2                                       
    REMARK 470     LEU C 485    CG   CD1  CD2                                       
    REMARK 470     ARG C 487    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     MET C 488    CG   SD   CE                                        
    REMARK 470     PHE C 489    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU C 491    CG   CD1  CD2                                       
    REMARK 470     ILE C 492    CG1  CG2  CD1                                       
    REMARK 470     MET C 495    CG   SD   CE                                        
    REMARK 470     CYS C 496    SG                                                  
    REMARK 470     SER C 498    OG                                                  
    REMARK 470     VAL C 499    CG1  CG2                                            
    REMARK 470     LYS C 500    CE   NZ                                             
    REMARK 470     GLU C 501    CG   CD   OE1  OE2                                  
    REMARK 470     ILE C 503    CG1  CG2  CD1                                       
    REMARK 470     ILE C 505    CG1  CG2  CD1                                       
    REMARK 470     PHE C 506    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU C 507    CG   CD1  CD2                                       
    REMARK 470     LEU C 508    CG   CD1  CD2                                       
    REMARK 470     SER C 518    OG                                                  
    REMARK 470     ASP C 519    CG   OD1  OD2                                       
    REMARK 470     PHE C 524    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     ILE C 534    CD1                                                 
    REMARK 470     SER C 536    OG                                                  
    REMARK 470     VAL C 537    CG1  CG2                                            
    REMARK 470     PHE C 538    CD1  CD2  CE1  CE2  CZ                              
    REMARK 470     LEU C 541    CG   CD1  CD2                                       
    REMARK 470     PHE C 542    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     TYR C 544    CG   CD1  CD2  CE1  CE2  CZ   OH                    
    REMARK 470     LYS C 545    CG   CD   CE   NZ                                   
    REMARK 470     GLU C 546    CG   CD   OE1  OE2                                  
    REMARK 470     CYS C 550    SG                                                  
    REMARK 470     MET C 572    CG   SD   CE                                        
    REMARK 470     MET C 574    CG   SD   CE                                        
    REMARK 470     VAL C 577    CG1  CG2                                            
    REMARK 470     MET C 578    CG   SD   CE                                        
    REMARK 470     ILE C 579    CG1  CG2  CD1                                       
    REMARK 470     ILE C 583    CG1  CG2  CD1                                       
    REMARK 470     LEU C 584    CG   CD1  CD2                                       
    REMARK 470     ASP C 586    CG   OD1  OD2                                       
    REMARK 470     ILE C 609    CG1  CG2  CD1                                       
    REMARK 470     GLU C 610    CG   CD   OE1  OE2                                  
    REMARK 470     LYS C 611    CG   CD   CE   NZ                                   
    REMARK 470     CYS C 612    SG                                                  
    REMARK 470     LYS C 614    CG   CD   CE   NZ                                   
    REMARK 470     ASP C 615    CG   OD1  OD2                                       
    REMARK 470     ASN C 616    CG   OD1  ND2                                       
    REMARK 470     LYS C 617    CG   CD   CE   NZ                                   
    REMARK 470     ASP C 618    CG   OD1  OD2                                       
    REMARK 470     CYS C 619    SG                                                  
    REMARK 470     SER C 624    OG                                                  
    REMARK 470     ASP C 627    OD1  OD2                                            
    REMARK 470     ASP C 641    CG   OD1  OD2                                       
    REMARK 470     GLN C 645    CG   CD   OE1  NE2                                  
    REMARK 470     GLN C 646    CG   CD   OE1  NE2                                  
    REMARK 470     ASN C 647    CG   OD1  ND2                                       
    REMARK 470     SER C 648    OG                                                  
    REMARK 470     LYS C 649    CG   CD   CE   NZ                                   
    REMARK 470     GLU C 679    CG   CD   OE1  OE2                                  
    REMARK 470     VAL C 681    CG1  CG2                                            
    REMARK 470     GLU C 682    CG   CD   OE1  OE2                                  
    REMARK 470     ASN C 683    CG   OD1  ND2                                       
    REMARK 470     VAL C 684    CG1  CG2                                            
    REMARK 470     SER C 685    OG                                                  
    REMARK 470     GLU C 687    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 689    CG   CD   OE1  OE2                                  
    REMARK 470     ARG C 690    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     GLN C 695    CG   CD   OE1  NE2                                  
    REMARK 470     ILE C 700    CD1                                                 
    REMARK 470     GLU C 702    CG   CD   OE1  OE2                                  
    REMARK 470     GLU C 704    CG   CD   OE1  OE2                                  
    REMARK 470     LYS C 705    CD   CE   NZ                                        
    REMARK 470     MET C 706    CG   SD   CE                                        
    REMARK 470     GLU C 709    CG   CD   OE1  OE2                                  
    REMARK 470     LEU C 711    CG   CD1  CD2                                       
    REMARK 470     ARG C 714    CG   CD   NE   CZ   NH1  NH2                        
    REMARK 470     MET C 717    CE                                                  
    REMARK 470     GLU C 719    CG   CD   OE1  OE2                                  
    REMARK 470     CYS C 721    SG                                                  
    REMARK 470     LYS C 722    CG   CD   CE   NZ                                   
    REMARK 470     GLU C 725    CG   CD   OE1  OE2                                  
    REMARK 470     ASP C 726    CG   OD1  OD2                                       
    REMARK 470     ASP C 727    CG   OD1  OD2                                       
    REMARK 470     GLU C 736    CG   CD   OE1  OE2                                  
    REMARK 470     LYS C 738    CG   CD   CE   NZ                                   
    REMARK 470     GLU C 741    CG   CD   OE1  OE2                                  
    REMARK 470     PHE C 748    CG   CD1  CD2  CE1  CE2  CZ                         
    REMARK 470     LEU C 749    CG   CD1  CD2                                       
    REMARK 470     ASN C 750    CG   OD1  ND2                                       
    REMARK 500                                                                      
    REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
    REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
    REMARK 500                                                                      
    REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
    REMARK 500                                                                      
    REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
    REMARK 500   O    TRP D   710     OG   SER D   713              2.07            
    REMARK 500   O    TRP B   710     OG   SER B   713              2.07            
    REMARK 500   O    TRP A   710     OG   SER A   713              2.07            
    REMARK 500   O    TRP C   710     OG   SER C   713              2.07            
    REMARK 500   O    LEU A   657     OG1  THR A   660              2.08            
    REMARK 500   O    LEU D   657     OG1  THR D   660              2.08            
    REMARK 500   O    LEU B   657     OG1  THR B   660              2.08            
    REMARK 500   O    LEU C   657     OG1  THR C   660              2.08            
    REMARK 500   OH   TYR B   321     OE2  GLU B   334              2.12            
    REMARK 500   OH   TYR D   321     OE2  GLU D   334              2.12            
    REMARK 500   OH   TYR A   321     OE2  GLU A   334              2.12            
    REMARK 500   OH   TYR C   321     OE2  GLU C   334              2.12            
    REMARK 500   O    TYR B   451     OG1  THR B   454              2.15            
    REMARK 500   O    TYR C   451     OG1  THR C   454              2.15            
    REMARK 500   O    TYR D   451     OG1  THR D   454              2.15            
    REMARK 500   O    TYR A   451     OG1  THR A   454              2.15            
    REMARK 500   O    ALA C   604     OG   SER C   607              2.17            
    REMARK 500   O    ALA A   604     OG   SER A   607              2.17            
    REMARK 500   O    ALA B   604     OG   SER B   607              2.17            
    REMARK 500   O    ALA D   604     OG   SER D   607              2.17            
    REMARK 500                                                                      
    REMARK 500 REMARK: NULL                                                         
    REMARK 500                                                                      
    REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
    REMARK 500 SUBTOPIC: TORSION ANGLES                                             
    REMARK 500                                                                      
    REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
    REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
    REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
    REMARK 500                                                                      
    REMARK 500 STANDARD TABLE:                                                      
    REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
    REMARK 500                                                                      
    REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
    REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
    REMARK 500                                                                      
    REMARK 500  M RES CSSEQI        PSI       PHI                                   
    REMARK 500    UNK A   3     -169.75   -165.08                                   
    REMARK 500    CYS A 131      -61.81   -105.13                                   
    REMARK 500    ARG A 226        3.87     81.12                                   
    REMARK 500    ALA A 354      -71.22    -91.53                                   
    REMARK 500    LYS A 376       71.23     61.44                                   
    REMARK 500    TYR A 382       95.88   -161.12                                   
    REMARK 500    LEU A 392       36.60   -141.00                                   
    REMARK 500    ASN A 394       28.53   -140.79                                   
    REMARK 500    THR A 421        4.09    -67.65                                   
    REMARK 500    TYR A 461       41.04   -104.03                                   
    REMARK 500    ASP A 519      -32.02   -130.57                                   
    REMARK 500    LEU A 642       98.22    -67.37                                   
    REMARK 500    THR A 680       46.48    -98.51                                   
    REMARK 500    UNK B   3     -169.75   -165.08                                   
    REMARK 500    CYS B 131      -61.83   -105.14                                   
    REMARK 500    ARG B 226        3.90     81.09                                   
    REMARK 500    ALA B 354      -71.28    -91.48                                   
    REMARK 500    LYS B 376       71.22     61.45                                   
    REMARK 500    TYR B 382       95.82   -161.13                                   
    REMARK 500    LEU B 392       36.60   -141.03                                   
    REMARK 500    ASN B 394       28.48   -140.81                                   
    REMARK 500    THR B 421        4.14    -67.64                                   
    REMARK 500    TYR B 461       41.03   -103.99                                   
    REMARK 500    ASP B 519      -32.02   -130.57                                   
    REMARK 500    LEU B 642       98.19    -67.31                                   
    REMARK 500    THR B 680       46.44    -98.50                                   
    REMARK 500    UNK D   3     -169.78   -165.10                                   
    REMARK 500    CYS D 131      -61.81   -105.09                                   
    REMARK 500    ARG D 226        3.86     81.09                                   
    REMARK 500    ALA D 354      -71.21    -91.55                                   
    REMARK 500    LYS D 376       71.26     61.47                                   
    REMARK 500    TYR D 382       95.88   -161.16                                   
    REMARK 500    LEU D 392       36.59   -141.03                                   
    REMARK 500    ASN D 394       28.52   -140.78                                   
    REMARK 500    THR D 421        4.11    -67.73                                   
    REMARK 500    TYR D 461       41.11   -104.09                                   
    REMARK 500    ASP D 519      -32.00   -130.56                                   
    REMARK 500    LEU D 642       98.18    -67.34                                   
    REMARK 500    THR D 680       46.55    -98.53                                   
    REMARK 500    UNK C   3     -169.75   -165.08                                   
    REMARK 500    CYS C 131      -61.80   -105.10                                   
    REMARK 500    ARG C 226        3.90     81.12                                   
    REMARK 500    ALA C 354      -71.25    -91.48                                   
    REMARK 500    LYS C 376       71.22     61.46                                   
    REMARK 500    TYR C 382       95.93   -161.10                                   
    REMARK 500    LEU C 392       36.60   -140.97                                   
    REMARK 500    ASN C 394       28.58   -140.81                                   
    REMARK 500    THR C 421        4.10    -67.67                                   
    REMARK 500    TYR C 461       41.03   -103.99                                   
    REMARK 500    ASP C 519      -31.94   -130.53                                   
    REMARK 500                                                                      
    REMARK 500 THIS ENTRY HAS      52 RAMACHANDRAN OUTLIERS.                        
    REMARK 500                                                                      
    REMARK 500 REMARK: NULL                                                         
    REMARK 900                                                                      
    REMARK 900 RELATED ENTRIES                                                      
    REMARK 900 RELATED ID: EMD-20192   RELATED DB: EMDB                             
    REMARK 900 STRUCTURE OF THE TRPV3 K169A SENSITIZED MUTANT IN APO FORM AT 4.1 A  
    REMARK 900 RESOLUTION                                                           
    REMARK 900 RELATED ID: EMD-20194   RELATED DB: EMDB                             
    REMARK 900 STRUCTURE OF THE TRPV3 K169A SENSITIZED MUTANT IN THE PRESENCE OF 2- 
    REMARK 900 APB AT 3.6 A RESOLUTION                                              
    DBREF  6OT2 A    1    14  PDB    6OT2     6OT2             1     14             
    DBREF  6OT2 A   97   790  UNP    Q8NET8   TRPV3_HUMAN     97    790             
    DBREF  6OT2 B    1    14  PDB    6OT2     6OT2             1     14             
    DBREF  6OT2 B   97   790  UNP    Q8NET8   TRPV3_HUMAN     97    790             
    DBREF  6OT2 D    1    14  PDB    6OT2     6OT2             1     14             
    DBREF  6OT2 D   97   790  UNP    Q8NET8   TRPV3_HUMAN     97    790             
    DBREF  6OT2 C    1    14  PDB    6OT2     6OT2             1     14             
    DBREF  6OT2 C   97   790  UNP    Q8NET8   TRPV3_HUMAN     97    790             
    SEQADV 6OT2 ALA A  169  UNP  Q8NET8    LYS   169 ENGINEERED MUTATION            
    SEQADV 6OT2 VAL A  791  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP A  792  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA A  793  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLY A  794  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LEU A  795  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLU A  796  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 VAL A  797  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LEU A  798  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 PHE A  799  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLN A  800  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLY A  801  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP A  802  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 TYR A  803  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LYS A  804  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP A  805  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP A  806  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP A  807  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP A  808  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LYS A  809  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA A  810  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS A  811  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS A  812  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS A  813  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS A  814  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS A  815  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS A  816  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA B  169  UNP  Q8NET8    LYS   169 ENGINEERED MUTATION            
    SEQADV 6OT2 VAL B  791  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP B  792  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA B  793  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLY B  794  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LEU B  795  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLU B  796  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 VAL B  797  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LEU B  798  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 PHE B  799  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLN B  800  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLY B  801  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP B  802  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 TYR B  803  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LYS B  804  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP B  805  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP B  806  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP B  807  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP B  808  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LYS B  809  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA B  810  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS B  811  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS B  812  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS B  813  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS B  814  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS B  815  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS B  816  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA D  169  UNP  Q8NET8    LYS   169 ENGINEERED MUTATION            
    SEQADV 6OT2 VAL D  791  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP D  792  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA D  793  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLY D  794  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LEU D  795  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLU D  796  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 VAL D  797  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LEU D  798  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 PHE D  799  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLN D  800  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLY D  801  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP D  802  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 TYR D  803  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LYS D  804  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP D  805  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP D  806  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP D  807  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP D  808  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LYS D  809  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA D  810  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS D  811  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS D  812  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS D  813  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS D  814  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS D  815  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS D  816  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA C  169  UNP  Q8NET8    LYS   169 ENGINEERED MUTATION            
    SEQADV 6OT2 VAL C  791  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP C  792  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA C  793  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLY C  794  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LEU C  795  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLU C  796  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 VAL C  797  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LEU C  798  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 PHE C  799  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLN C  800  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 GLY C  801  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP C  802  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 TYR C  803  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LYS C  804  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP C  805  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP C  806  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP C  807  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ASP C  808  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 LYS C  809  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 ALA C  810  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS C  811  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS C  812  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS C  813  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS C  814  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS C  815  UNP  Q8NET8              EXPRESSION TAG                 
    SEQADV 6OT2 HIS C  816  UNP  Q8NET8              EXPRESSION TAG                 
    SEQRES   1 A  734  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
    SEQRES   2 A  734  UNK PRO SER ASN PRO ASN SER PRO SER ALA GLN LEU ALA          
    SEQRES   3 A  734  LYS GLU GLU GLN ARG ARG LYS LYS ARG ARG LEU LYS LYS          
    SEQRES   4 A  734  ARG ILE PHE ALA ALA VAL SER GLU GLY CYS VAL GLU GLU          
    SEQRES   5 A  734  LEU VAL GLU LEU LEU VAL GLU LEU GLN GLU LEU CYS ARG          
    SEQRES   6 A  734  ARG ARG HIS ASP GLU ASP VAL PRO ASP PHE LEU MET HIS          
    SEQRES   7 A  734  LYS LEU THR ALA SER ASP THR GLY ALA THR CYS LEU MET          
    SEQRES   8 A  734  LYS ALA LEU LEU ASN ILE ASN PRO ASN THR LYS GLU ILE          
    SEQRES   9 A  734  VAL ARG ILE LEU LEU ALA PHE ALA GLU GLU ASN ASP ILE          
    SEQRES  10 A  734  LEU GLY ARG PHE ILE ASN ALA GLU TYR THR GLU GLU ALA          
    SEQRES  11 A  734  TYR GLU GLY GLN THR ALA LEU ASN ILE ALA ILE GLU ARG          
    SEQRES  12 A  734  ARG GLN GLY ASP ILE ALA ALA LEU LEU ILE ALA ALA GLY          
    SEQRES  13 A  734  ALA ASP VAL ASN ALA HIS ALA LYS GLY ALA PHE PHE ASN          
    SEQRES  14 A  734  PRO LYS TYR GLN HIS GLU GLY PHE TYR PHE GLY GLU THR          
    SEQRES  15 A  734  PRO LEU ALA LEU ALA ALA CYS THR ASN GLN PRO GLU ILE          
    SEQRES  16 A  734  VAL GLN LEU LEU MET GLU HIS GLU GLN THR ASP ILE THR          
    SEQRES  17 A  734  SER ARG ASP SER ARG GLY ASN ASN ILE LEU HIS ALA LEU          
    SEQRES  18 A  734  VAL THR VAL ALA GLU ASP PHE LYS THR GLN ASN ASP PHE          
    SEQRES  19 A  734  VAL LYS ARG MET TYR ASP MET ILE LEU LEU ARG SER GLY          
    SEQRES  20 A  734  ASN TRP GLU LEU GLU THR THR ARG ASN ASN ASP GLY LEU          
    SEQRES  21 A  734  THR PRO LEU GLN LEU ALA ALA LYS MET GLY LYS ALA GLU          
    SEQRES  22 A  734  ILE LEU LYS TYR ILE LEU SER ARG GLU ILE LYS GLU LYS          
    SEQRES  23 A  734  ARG LEU ARG SER LEU SER ARG LYS PHE THR ASP TRP ALA          
    SEQRES  24 A  734  TYR GLY PRO VAL SER SER SER LEU TYR ASP LEU THR ASN          
    SEQRES  25 A  734  VAL ASP THR THR THR ASP ASN SER VAL LEU GLU ILE THR          
    SEQRES  26 A  734  VAL TYR ASN THR ASN ILE ASP ASN ARG HIS GLU MET LEU          
    SEQRES  27 A  734  THR LEU GLU PRO LEU HIS THR LEU LEU HIS MET LYS TRP          
    SEQRES  28 A  734  LYS LYS PHE ALA LYS HIS MET PHE PHE LEU SER PHE CYS          
    SEQRES  29 A  734  PHE TYR PHE PHE TYR ASN ILE THR LEU THR LEU VAL SER          
    SEQRES  30 A  734  TYR TYR ARG PRO ARG GLU GLU GLU ALA ILE PRO HIS PRO          
    SEQRES  31 A  734  LEU ALA LEU THR HIS LYS MET GLY TRP LEU GLN LEU LEU          
    SEQRES  32 A  734  GLY ARG MET PHE VAL LEU ILE TRP ALA MET CYS ILE SER          
    SEQRES  33 A  734  VAL LYS GLU GLY ILE ALA ILE PHE LEU LEU ARG PRO SER          
    SEQRES  34 A  734  ASP LEU GLN SER ILE LEU SER ASP ALA TRP PHE HIS PHE          
    SEQRES  35 A  734  VAL PHE PHE ILE GLN ALA VAL LEU VAL ILE LEU SER VAL          
    SEQRES  36 A  734  PHE LEU TYR LEU PHE ALA TYR LYS GLU TYR LEU ALA CYS          
    SEQRES  37 A  734  LEU VAL LEU ALA MET ALA LEU GLY TRP ALA ASN MET LEU          
    SEQRES  38 A  734  TYR TYR THR ARG GLY PHE GLN SER MET GLY MET TYR SER          
    SEQRES  39 A  734  VAL MET ILE GLN LYS VAL ILE LEU HIS ASP VAL LEU LYS          
    SEQRES  40 A  734  PHE LEU PHE VAL TYR ILE VAL PHE LEU LEU GLY PHE GLY          
    SEQRES  41 A  734  VAL ALA LEU ALA SER LEU ILE GLU LYS CYS PRO LYS ASP          
    SEQRES  42 A  734  ASN LYS ASP CYS SER SER TYR GLY SER PHE SER ASP ALA          
    SEQRES  43 A  734  VAL LEU GLU LEU PHE LYS LEU THR ILE GLY LEU GLY ASP          
    SEQRES  44 A  734  LEU ASN ILE GLN GLN ASN SER LYS TYR PRO ILE LEU PHE          
    SEQRES  45 A  734  LEU PHE LEU LEU ILE THR TYR VAL ILE LEU THR PHE VAL          
    SEQRES  46 A  734  LEU LEU LEU ASN MET LEU ILE ALA LEU MET GLY GLU THR          
    SEQRES  47 A  734  VAL GLU ASN VAL SER LYS GLU SER GLU ARG ILE TRP ARG          
    SEQRES  48 A  734  LEU GLN ARG ALA ARG THR ILE LEU GLU PHE GLU LYS MET          
    SEQRES  49 A  734  LEU PRO GLU TRP LEU ARG SER ARG PHE ARG MET GLY GLU          
    SEQRES  50 A  734  LEU CYS LYS VAL ALA GLU ASP ASP PHE ARG LEU CYS LEU          
    SEQRES  51 A  734  ARG ILE ASN GLU VAL LYS TRP THR GLU TRP LYS THR HIS          
    SEQRES  52 A  734  VAL SER PHE LEU ASN GLU ASP PRO GLY PRO VAL ARG ARG          
    SEQRES  53 A  734  THR ASP PHE ASN LYS ILE GLN ASP SER SER ARG ASN ASN          
    SEQRES  54 A  734  SER LYS THR THR LEU ASN ALA PHE GLU GLU VAL GLU GLU          
    SEQRES  55 A  734  PHE PRO GLU THR SER VAL VAL ASP ALA GLY LEU GLU VAL          
    SEQRES  56 A  734  LEU PHE GLN GLY ASP TYR LYS ASP ASP ASP ASP LYS ALA          
    SEQRES  57 A  734  HIS HIS HIS HIS HIS HIS                                      
    SEQRES   1 B  734  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
    SEQRES   2 B  734  UNK PRO SER ASN PRO ASN SER PRO SER ALA GLN LEU ALA          
    SEQRES   3 B  734  LYS GLU GLU GLN ARG ARG LYS LYS ARG ARG LEU LYS LYS          
    SEQRES   4 B  734  ARG ILE PHE ALA ALA VAL SER GLU GLY CYS VAL GLU GLU          
    SEQRES   5 B  734  LEU VAL GLU LEU LEU VAL GLU LEU GLN GLU LEU CYS ARG          
    SEQRES   6 B  734  ARG ARG HIS ASP GLU ASP VAL PRO ASP PHE LEU MET HIS          
    SEQRES   7 B  734  LYS LEU THR ALA SER ASP THR GLY ALA THR CYS LEU MET          
    SEQRES   8 B  734  LYS ALA LEU LEU ASN ILE ASN PRO ASN THR LYS GLU ILE          
    SEQRES   9 B  734  VAL ARG ILE LEU LEU ALA PHE ALA GLU GLU ASN ASP ILE          
    SEQRES  10 B  734  LEU GLY ARG PHE ILE ASN ALA GLU TYR THR GLU GLU ALA          
    SEQRES  11 B  734  TYR GLU GLY GLN THR ALA LEU ASN ILE ALA ILE GLU ARG          
    SEQRES  12 B  734  ARG GLN GLY ASP ILE ALA ALA LEU LEU ILE ALA ALA GLY          
    SEQRES  13 B  734  ALA ASP VAL ASN ALA HIS ALA LYS GLY ALA PHE PHE ASN          
    SEQRES  14 B  734  PRO LYS TYR GLN HIS GLU GLY PHE TYR PHE GLY GLU THR          
    SEQRES  15 B  734  PRO LEU ALA LEU ALA ALA CYS THR ASN GLN PRO GLU ILE          
    SEQRES  16 B  734  VAL GLN LEU LEU MET GLU HIS GLU GLN THR ASP ILE THR          
    SEQRES  17 B  734  SER ARG ASP SER ARG GLY ASN ASN ILE LEU HIS ALA LEU          
    SEQRES  18 B  734  VAL THR VAL ALA GLU ASP PHE LYS THR GLN ASN ASP PHE          
    SEQRES  19 B  734  VAL LYS ARG MET TYR ASP MET ILE LEU LEU ARG SER GLY          
    SEQRES  20 B  734  ASN TRP GLU LEU GLU THR THR ARG ASN ASN ASP GLY LEU          
    SEQRES  21 B  734  THR PRO LEU GLN LEU ALA ALA LYS MET GLY LYS ALA GLU          
    SEQRES  22 B  734  ILE LEU LYS TYR ILE LEU SER ARG GLU ILE LYS GLU LYS          
    SEQRES  23 B  734  ARG LEU ARG SER LEU SER ARG LYS PHE THR ASP TRP ALA          
    SEQRES  24 B  734  TYR GLY PRO VAL SER SER SER LEU TYR ASP LEU THR ASN          
    SEQRES  25 B  734  VAL ASP THR THR THR ASP ASN SER VAL LEU GLU ILE THR          
    SEQRES  26 B  734  VAL TYR ASN THR ASN ILE ASP ASN ARG HIS GLU MET LEU          
    SEQRES  27 B  734  THR LEU GLU PRO LEU HIS THR LEU LEU HIS MET LYS TRP          
    SEQRES  28 B  734  LYS LYS PHE ALA LYS HIS MET PHE PHE LEU SER PHE CYS          
    SEQRES  29 B  734  PHE TYR PHE PHE TYR ASN ILE THR LEU THR LEU VAL SER          
    SEQRES  30 B  734  TYR TYR ARG PRO ARG GLU GLU GLU ALA ILE PRO HIS PRO          
    SEQRES  31 B  734  LEU ALA LEU THR HIS LYS MET GLY TRP LEU GLN LEU LEU          
    SEQRES  32 B  734  GLY ARG MET PHE VAL LEU ILE TRP ALA MET CYS ILE SER          
    SEQRES  33 B  734  VAL LYS GLU GLY ILE ALA ILE PHE LEU LEU ARG PRO SER          
    SEQRES  34 B  734  ASP LEU GLN SER ILE LEU SER ASP ALA TRP PHE HIS PHE          
    SEQRES  35 B  734  VAL PHE PHE ILE GLN ALA VAL LEU VAL ILE LEU SER VAL          
    SEQRES  36 B  734  PHE LEU TYR LEU PHE ALA TYR LYS GLU TYR LEU ALA CYS          
    SEQRES  37 B  734  LEU VAL LEU ALA MET ALA LEU GLY TRP ALA ASN MET LEU          
    SEQRES  38 B  734  TYR TYR THR ARG GLY PHE GLN SER MET GLY MET TYR SER          
    SEQRES  39 B  734  VAL MET ILE GLN LYS VAL ILE LEU HIS ASP VAL LEU LYS          
    SEQRES  40 B  734  PHE LEU PHE VAL TYR ILE VAL PHE LEU LEU GLY PHE GLY          
    SEQRES  41 B  734  VAL ALA LEU ALA SER LEU ILE GLU LYS CYS PRO LYS ASP          
    SEQRES  42 B  734  ASN LYS ASP CYS SER SER TYR GLY SER PHE SER ASP ALA          
    SEQRES  43 B  734  VAL LEU GLU LEU PHE LYS LEU THR ILE GLY LEU GLY ASP          
    SEQRES  44 B  734  LEU ASN ILE GLN GLN ASN SER LYS TYR PRO ILE LEU PHE          
    SEQRES  45 B  734  LEU PHE LEU LEU ILE THR TYR VAL ILE LEU THR PHE VAL          
    SEQRES  46 B  734  LEU LEU LEU ASN MET LEU ILE ALA LEU MET GLY GLU THR          
    SEQRES  47 B  734  VAL GLU ASN VAL SER LYS GLU SER GLU ARG ILE TRP ARG          
    SEQRES  48 B  734  LEU GLN ARG ALA ARG THR ILE LEU GLU PHE GLU LYS MET          
    SEQRES  49 B  734  LEU PRO GLU TRP LEU ARG SER ARG PHE ARG MET GLY GLU          
    SEQRES  50 B  734  LEU CYS LYS VAL ALA GLU ASP ASP PHE ARG LEU CYS LEU          
    SEQRES  51 B  734  ARG ILE ASN GLU VAL LYS TRP THR GLU TRP LYS THR HIS          
    SEQRES  52 B  734  VAL SER PHE LEU ASN GLU ASP PRO GLY PRO VAL ARG ARG          
    SEQRES  53 B  734  THR ASP PHE ASN LYS ILE GLN ASP SER SER ARG ASN ASN          
    SEQRES  54 B  734  SER LYS THR THR LEU ASN ALA PHE GLU GLU VAL GLU GLU          
    SEQRES  55 B  734  PHE PRO GLU THR SER VAL VAL ASP ALA GLY LEU GLU VAL          
    SEQRES  56 B  734  LEU PHE GLN GLY ASP TYR LYS ASP ASP ASP ASP LYS ALA          
    SEQRES  57 B  734  HIS HIS HIS HIS HIS HIS                                      
    SEQRES   1 D  734  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
    SEQRES   2 D  734  UNK PRO SER ASN PRO ASN SER PRO SER ALA GLN LEU ALA          
    SEQRES   3 D  734  LYS GLU GLU GLN ARG ARG LYS LYS ARG ARG LEU LYS LYS          
    SEQRES   4 D  734  ARG ILE PHE ALA ALA VAL SER GLU GLY CYS VAL GLU GLU          
    SEQRES   5 D  734  LEU VAL GLU LEU LEU VAL GLU LEU GLN GLU LEU CYS ARG          
    SEQRES   6 D  734  ARG ARG HIS ASP GLU ASP VAL PRO ASP PHE LEU MET HIS          
    SEQRES   7 D  734  LYS LEU THR ALA SER ASP THR GLY ALA THR CYS LEU MET          
    SEQRES   8 D  734  LYS ALA LEU LEU ASN ILE ASN PRO ASN THR LYS GLU ILE          
    SEQRES   9 D  734  VAL ARG ILE LEU LEU ALA PHE ALA GLU GLU ASN ASP ILE          
    SEQRES  10 D  734  LEU GLY ARG PHE ILE ASN ALA GLU TYR THR GLU GLU ALA          
    SEQRES  11 D  734  TYR GLU GLY GLN THR ALA LEU ASN ILE ALA ILE GLU ARG          
    SEQRES  12 D  734  ARG GLN GLY ASP ILE ALA ALA LEU LEU ILE ALA ALA GLY          
    SEQRES  13 D  734  ALA ASP VAL ASN ALA HIS ALA LYS GLY ALA PHE PHE ASN          
    SEQRES  14 D  734  PRO LYS TYR GLN HIS GLU GLY PHE TYR PHE GLY GLU THR          
    SEQRES  15 D  734  PRO LEU ALA LEU ALA ALA CYS THR ASN GLN PRO GLU ILE          
    SEQRES  16 D  734  VAL GLN LEU LEU MET GLU HIS GLU GLN THR ASP ILE THR          
    SEQRES  17 D  734  SER ARG ASP SER ARG GLY ASN ASN ILE LEU HIS ALA LEU          
    SEQRES  18 D  734  VAL THR VAL ALA GLU ASP PHE LYS THR GLN ASN ASP PHE          
    SEQRES  19 D  734  VAL LYS ARG MET TYR ASP MET ILE LEU LEU ARG SER GLY          
    SEQRES  20 D  734  ASN TRP GLU LEU GLU THR THR ARG ASN ASN ASP GLY LEU          
    SEQRES  21 D  734  THR PRO LEU GLN LEU ALA ALA LYS MET GLY LYS ALA GLU          
    SEQRES  22 D  734  ILE LEU LYS TYR ILE LEU SER ARG GLU ILE LYS GLU LYS          
    SEQRES  23 D  734  ARG LEU ARG SER LEU SER ARG LYS PHE THR ASP TRP ALA          
    SEQRES  24 D  734  TYR GLY PRO VAL SER SER SER LEU TYR ASP LEU THR ASN          
    SEQRES  25 D  734  VAL ASP THR THR THR ASP ASN SER VAL LEU GLU ILE THR          
    SEQRES  26 D  734  VAL TYR ASN THR ASN ILE ASP ASN ARG HIS GLU MET LEU          
    SEQRES  27 D  734  THR LEU GLU PRO LEU HIS THR LEU LEU HIS MET LYS TRP          
    SEQRES  28 D  734  LYS LYS PHE ALA LYS HIS MET PHE PHE LEU SER PHE CYS          
    SEQRES  29 D  734  PHE TYR PHE PHE TYR ASN ILE THR LEU THR LEU VAL SER          
    SEQRES  30 D  734  TYR TYR ARG PRO ARG GLU GLU GLU ALA ILE PRO HIS PRO          
    SEQRES  31 D  734  LEU ALA LEU THR HIS LYS MET GLY TRP LEU GLN LEU LEU          
    SEQRES  32 D  734  GLY ARG MET PHE VAL LEU ILE TRP ALA MET CYS ILE SER          
    SEQRES  33 D  734  VAL LYS GLU GLY ILE ALA ILE PHE LEU LEU ARG PRO SER          
    SEQRES  34 D  734  ASP LEU GLN SER ILE LEU SER ASP ALA TRP PHE HIS PHE          
    SEQRES  35 D  734  VAL PHE PHE ILE GLN ALA VAL LEU VAL ILE LEU SER VAL          
    SEQRES  36 D  734  PHE LEU TYR LEU PHE ALA TYR LYS GLU TYR LEU ALA CYS          
    SEQRES  37 D  734  LEU VAL LEU ALA MET ALA LEU GLY TRP ALA ASN MET LEU          
    SEQRES  38 D  734  TYR TYR THR ARG GLY PHE GLN SER MET GLY MET TYR SER          
    SEQRES  39 D  734  VAL MET ILE GLN LYS VAL ILE LEU HIS ASP VAL LEU LYS          
    SEQRES  40 D  734  PHE LEU PHE VAL TYR ILE VAL PHE LEU LEU GLY PHE GLY          
    SEQRES  41 D  734  VAL ALA LEU ALA SER LEU ILE GLU LYS CYS PRO LYS ASP          
    SEQRES  42 D  734  ASN LYS ASP CYS SER SER TYR GLY SER PHE SER ASP ALA          
    SEQRES  43 D  734  VAL LEU GLU LEU PHE LYS LEU THR ILE GLY LEU GLY ASP          
    SEQRES  44 D  734  LEU ASN ILE GLN GLN ASN SER LYS TYR PRO ILE LEU PHE          
    SEQRES  45 D  734  LEU PHE LEU LEU ILE THR TYR VAL ILE LEU THR PHE VAL          
    SEQRES  46 D  734  LEU LEU LEU ASN MET LEU ILE ALA LEU MET GLY GLU THR          
    SEQRES  47 D  734  VAL GLU ASN VAL SER LYS GLU SER GLU ARG ILE TRP ARG          
    SEQRES  48 D  734  LEU GLN ARG ALA ARG THR ILE LEU GLU PHE GLU LYS MET          
    SEQRES  49 D  734  LEU PRO GLU TRP LEU ARG SER ARG PHE ARG MET GLY GLU          
    SEQRES  50 D  734  LEU CYS LYS VAL ALA GLU ASP ASP PHE ARG LEU CYS LEU          
    SEQRES  51 D  734  ARG ILE ASN GLU VAL LYS TRP THR GLU TRP LYS THR HIS          
    SEQRES  52 D  734  VAL SER PHE LEU ASN GLU ASP PRO GLY PRO VAL ARG ARG          
    SEQRES  53 D  734  THR ASP PHE ASN LYS ILE GLN ASP SER SER ARG ASN ASN          
    SEQRES  54 D  734  SER LYS THR THR LEU ASN ALA PHE GLU GLU VAL GLU GLU          
    SEQRES  55 D  734  PHE PRO GLU THR SER VAL VAL ASP ALA GLY LEU GLU VAL          
    SEQRES  56 D  734  LEU PHE GLN GLY ASP TYR LYS ASP ASP ASP ASP LYS ALA          
    SEQRES  57 D  734  HIS HIS HIS HIS HIS HIS                                      
    SEQRES   1 C  734  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
    SEQRES   2 C  734  UNK PRO SER ASN PRO ASN SER PRO SER ALA GLN LEU ALA          
    SEQRES   3 C  734  LYS GLU GLU GLN ARG ARG LYS LYS ARG ARG LEU LYS LYS          
    SEQRES   4 C  734  ARG ILE PHE ALA ALA VAL SER GLU GLY CYS VAL GLU GLU          
    SEQRES   5 C  734  LEU VAL GLU LEU LEU VAL GLU LEU GLN GLU LEU CYS ARG          
    SEQRES   6 C  734  ARG ARG HIS ASP GLU ASP VAL PRO ASP PHE LEU MET HIS          
    SEQRES   7 C  734  LYS LEU THR ALA SER ASP THR GLY ALA THR CYS LEU MET          
    SEQRES   8 C  734  LYS ALA LEU LEU ASN ILE ASN PRO ASN THR LYS GLU ILE          
    SEQRES   9 C  734  VAL ARG ILE LEU LEU ALA PHE ALA GLU GLU ASN ASP ILE          
    SEQRES  10 C  734  LEU GLY ARG PHE ILE ASN ALA GLU TYR THR GLU GLU ALA          
    SEQRES  11 C  734  TYR GLU GLY GLN THR ALA LEU ASN ILE ALA ILE GLU ARG          
    SEQRES  12 C  734  ARG GLN GLY ASP ILE ALA ALA LEU LEU ILE ALA ALA GLY          
    SEQRES  13 C  734  ALA ASP VAL ASN ALA HIS ALA LYS GLY ALA PHE PHE ASN          
    SEQRES  14 C  734  PRO LYS TYR GLN HIS GLU GLY PHE TYR PHE GLY GLU THR          
    SEQRES  15 C  734  PRO LEU ALA LEU ALA ALA CYS THR ASN GLN PRO GLU ILE          
    SEQRES  16 C  734  VAL GLN LEU LEU MET GLU HIS GLU GLN THR ASP ILE THR          
    SEQRES  17 C  734  SER ARG ASP SER ARG GLY ASN ASN ILE LEU HIS ALA LEU          
    SEQRES  18 C  734  VAL THR VAL ALA GLU ASP PHE LYS THR GLN ASN ASP PHE          
    SEQRES  19 C  734  VAL LYS ARG MET TYR ASP MET ILE LEU LEU ARG SER GLY          
    SEQRES  20 C  734  ASN TRP GLU LEU GLU THR THR ARG ASN ASN ASP GLY LEU          
    SEQRES  21 C  734  THR PRO LEU GLN LEU ALA ALA LYS MET GLY LYS ALA GLU          
    SEQRES  22 C  734  ILE LEU LYS TYR ILE LEU SER ARG GLU ILE LYS GLU LYS          
    SEQRES  23 C  734  ARG LEU ARG SER LEU SER ARG LYS PHE THR ASP TRP ALA          
    SEQRES  24 C  734  TYR GLY PRO VAL SER SER SER LEU TYR ASP LEU THR ASN          
    SEQRES  25 C  734  VAL ASP THR THR THR ASP ASN SER VAL LEU GLU ILE THR          
    SEQRES  26 C  734  VAL TYR ASN THR ASN ILE ASP ASN ARG HIS GLU MET LEU          
    SEQRES  27 C  734  THR LEU GLU PRO LEU HIS THR LEU LEU HIS MET LYS TRP          
    SEQRES  28 C  734  LYS LYS PHE ALA LYS HIS MET PHE PHE LEU SER PHE CYS          
    SEQRES  29 C  734  PHE TYR PHE PHE TYR ASN ILE THR LEU THR LEU VAL SER          
    SEQRES  30 C  734  TYR TYR ARG PRO ARG GLU GLU GLU ALA ILE PRO HIS PRO          
    SEQRES  31 C  734  LEU ALA LEU THR HIS LYS MET GLY TRP LEU GLN LEU LEU          
    SEQRES  32 C  734  GLY ARG MET PHE VAL LEU ILE TRP ALA MET CYS ILE SER          
    SEQRES  33 C  734  VAL LYS GLU GLY ILE ALA ILE PHE LEU LEU ARG PRO SER          
    SEQRES  34 C  734  ASP LEU GLN SER ILE LEU SER ASP ALA TRP PHE HIS PHE          
    SEQRES  35 C  734  VAL PHE PHE ILE GLN ALA VAL LEU VAL ILE LEU SER VAL          
    SEQRES  36 C  734  PHE LEU TYR LEU PHE ALA TYR LYS GLU TYR LEU ALA CYS          
    SEQRES  37 C  734  LEU VAL LEU ALA MET ALA LEU GLY TRP ALA ASN MET LEU          
    SEQRES  38 C  734  TYR TYR THR ARG GLY PHE GLN SER MET GLY MET TYR SER          
    SEQRES  39 C  734  VAL MET ILE GLN LYS VAL ILE LEU HIS ASP VAL LEU LYS          
    SEQRES  40 C  734  PHE LEU PHE VAL TYR ILE VAL PHE LEU LEU GLY PHE GLY          
    SEQRES  41 C  734  VAL ALA LEU ALA SER LEU ILE GLU LYS CYS PRO LYS ASP          
    SEQRES  42 C  734  ASN LYS ASP CYS SER SER TYR GLY SER PHE SER ASP ALA          
    SEQRES  43 C  734  VAL LEU GLU LEU PHE LYS LEU THR ILE GLY LEU GLY ASP          
    SEQRES  44 C  734  LEU ASN ILE GLN GLN ASN SER LYS TYR PRO ILE LEU PHE          
    SEQRES  45 C  734  LEU PHE LEU LEU ILE THR TYR VAL ILE LEU THR PHE VAL          
    SEQRES  46 C  734  LEU LEU LEU ASN MET LEU ILE ALA LEU MET GLY GLU THR          
    SEQRES  47 C  734  VAL GLU ASN VAL SER LYS GLU SER GLU ARG ILE TRP ARG          
    SEQRES  48 C  734  LEU GLN ARG ALA ARG THR ILE LEU GLU PHE GLU LYS MET          
    SEQRES  49 C  734  LEU PRO GLU TRP LEU ARG SER ARG PHE ARG MET GLY GLU          
    SEQRES  50 C  734  LEU CYS LYS VAL ALA GLU ASP ASP PHE ARG LEU CYS LEU          
    SEQRES  51 C  734  ARG ILE ASN GLU VAL LYS TRP THR GLU TRP LYS THR HIS          
    SEQRES  52 C  734  VAL SER PHE LEU ASN GLU ASP PRO GLY PRO VAL ARG ARG          
    SEQRES  53 C  734  THR ASP PHE ASN LYS ILE GLN ASP SER SER ARG ASN ASN          
    SEQRES  54 C  734  SER LYS THR THR LEU ASN ALA PHE GLU GLU VAL GLU GLU          
    SEQRES  55 C  734  PHE PRO GLU THR SER VAL VAL ASP ALA GLY LEU GLU VAL          
    SEQRES  56 C  734  LEU PHE GLN GLY ASP TYR LYS ASP ASP ASP ASP LYS ALA          
    SEQRES  57 C  734  HIS HIS HIS HIS HIS HIS                                      
    HELIX    1 AA1 GLU A  111  GLY A  130  1                                  20    
    HELIX    2 AA2 VAL A  132  ARG A  149  1                                  18    
    HELIX    3 AA3 PRO A  155  THR A  163  1                                   9    
    HELIX    4 AA4 THR A  170  ASN A  178  1                                   9    
    HELIX    5 AA5 ASN A  182  ASP A  198  1                                  17    
    HELIX    6 AA6 ILE A  199  ASN A  205  1                                   7    
    HELIX    7 AA7 THR A  217  ARG A  225  1                                   9    
    HELIX    8 AA8 GLY A  228  ALA A  239  1                                  12    
    HELIX    9 AA9 THR A  264  THR A  272  1                                   9    
    HELIX   10 AB1 PRO A  275  HIS A  284  1                                  10    
    HELIX   11 AB2 ASN A  298  THR A  305  1                                   8    
    HELIX   12 AB3 ASP A  315  SER A  328  1                                  14    
    HELIX   13 AB4 THR A  343  MET A  351  1                                   9    
    HELIX   14 AB5 ALA A  354  SER A  362  1                                   9    
    HELIX   15 AB6 GLU A  367  SER A  374  1                                   8    
    HELIX   16 AB7 SER A  402  TYR A  409  1                                   8    
    HELIX   17 AB8 ASN A  415  THR A  421  1                                   7    
    HELIX   18 AB9 LEU A  422  TYR A  461  1                                  40    
    HELIX   19 AC1 TRP A  481  LEU A  507  1                                  27    
    HELIX   20 AC2 ALA A  520  PHE A  542  1                                  23    
    HELIX   21 AC3 GLU A  546  ASN A  561  1                                  16    
    HELIX   22 AC4 MET A  562  GLY A  568  5                                   7    
    HELIX   23 AC5 PHE A  569  ASP A  586  1                                  18    
    HELIX   24 AC6 ASP A  586  ILE A  609  1                                  24    
    HELIX   25 AC7 SER A  624  GLY A  638  1                                  15    
    HELIX   26 AC8 TYR A  650  THR A  680  1                                  31    
    HELIX   27 AC9 ASN A  683  LEU A  707  1                                  25    
    HELIX   28 AD1 PRO A  708  ARG A  716  1                                   9    
    HELIX   29 AD2 LYS A  738  ASN A  750  1                                  13    
    HELIX   30 AD3 GLU B  111  GLY B  130  1                                  20    
    HELIX   31 AD4 VAL B  132  ARG B  149  1                                  18    
    HELIX   32 AD5 PRO B  155  THR B  163  1                                   9    
    HELIX   33 AD6 THR B  170  ASN B  178  1                                   9    
    HELIX   34 AD7 ASN B  182  ASP B  198  1                                  17    
    HELIX   35 AD8 ILE B  199  ASN B  205  1                                   7    
    HELIX   36 AD9 THR B  217  ARG B  225  1                                   9    
    HELIX   37 AE1 GLY B  228  ALA B  239  1                                  12    
    HELIX   38 AE2 THR B  264  THR B  272  1                                   9    
    HELIX   39 AE3 PRO B  275  HIS B  284  1                                  10    
    HELIX   40 AE4 ASN B  298  THR B  305  1                                   8    
    HELIX   41 AE5 ASP B  315  SER B  328  1                                  14    
    HELIX   42 AE6 THR B  343  MET B  351  1                                   9    
    HELIX   43 AE7 ALA B  354  SER B  362  1                                   9    
    HELIX   44 AE8 GLU B  367  SER B  374  1                                   8    
    HELIX   45 AE9 SER B  402  TYR B  409  1                                   8    
    HELIX   46 AF1 ASN B  415  THR B  421  1                                   7    
    HELIX   47 AF2 LEU B  422  TYR B  461  1                                  40    
    HELIX   48 AF3 TRP B  481  LEU B  507  1                                  27    
    HELIX   49 AF4 ALA B  520  PHE B  542  1                                  23    
    HELIX   50 AF5 GLU B  546  ASN B  561  1                                  16    
    HELIX   51 AF6 MET B  562  GLY B  568  5                                   7    
    HELIX   52 AF7 PHE B  569  ASP B  586  1                                  18    
    HELIX   53 AF8 ASP B  586  ILE B  609  1                                  24    
    HELIX   54 AF9 SER B  624  GLY B  638  1                                  15    
    HELIX   55 AG1 TYR B  650  THR B  680  1                                  31    
    HELIX   56 AG2 ASN B  683  LEU B  707  1                                  25    
    HELIX   57 AG3 PRO B  708  ARG B  716  1                                   9    
    HELIX   58 AG4 LYS B  738  ASN B  750  1                                  13    
    HELIX   59 AG5 GLU D  111  GLY D  130  1                                  20    
    HELIX   60 AG6 VAL D  132  ARG D  149  1                                  18    
    HELIX   61 AG7 PRO D  155  THR D  163  1                                   9    
    HELIX   62 AG8 THR D  170  ASN D  178  1                                   9    
    HELIX   63 AG9 ASN D  182  ASP D  198  1                                  17    
    HELIX   64 AH1 ILE D  199  ASN D  205  1                                   7    
    HELIX   65 AH2 THR D  217  ARG D  225  1                                   9    
    HELIX   66 AH3 GLY D  228  ALA D  239  1                                  12    
    HELIX   67 AH4 THR D  264  THR D  272  1                                   9    
    HELIX   68 AH5 PRO D  275  HIS D  284  1                                  10    
    HELIX   69 AH6 ASN D  298  THR D  305  1                                   8    
    HELIX   70 AH7 ASP D  315  SER D  328  1                                  14    
    HELIX   71 AH8 THR D  343  MET D  351  1                                   9    
    HELIX   72 AH9 ALA D  354  SER D  362  1                                   9    
    HELIX   73 AI1 GLU D  367  SER D  374  1                                   8    
    HELIX   74 AI2 SER D  402  TYR D  409  1                                   8    
    HELIX   75 AI3 ASN D  415  THR D  421  1                                   7    
    HELIX   76 AI4 LEU D  422  TYR D  461  1                                  40    
    HELIX   77 AI5 TRP D  481  LEU D  507  1                                  27    
    HELIX   78 AI6 ALA D  520  PHE D  542  1                                  23    
    HELIX   79 AI7 GLU D  546  ASN D  561  1                                  16    
    HELIX   80 AI8 MET D  562  GLY D  568  5                                   7    
    HELIX   81 AI9 PHE D  569  ASP D  586  1                                  18    
    HELIX   82 AJ1 ASP D  586  ILE D  609  1                                  24    
    HELIX   83 AJ2 SER D  624  GLY D  638  1                                  15    
    HELIX   84 AJ3 TYR D  650  THR D  680  1                                  31    
    HELIX   85 AJ4 ASN D  683  LEU D  707  1                                  25    
    HELIX   86 AJ5 PRO D  708  ARG D  716  1                                   9    
    HELIX   87 AJ6 LYS D  738  ASN D  750  1                                  13    
    HELIX   88 AJ7 GLU C  111  GLY C  130  1                                  20    
    HELIX   89 AJ8 VAL C  132  ARG C  149  1                                  18    
    HELIX   90 AJ9 PRO C  155  THR C  163  1                                   9    
    HELIX   91 AK1 THR C  170  ASN C  178  1                                   9    
    HELIX   92 AK2 ASN C  182  ASP C  198  1                                  17    
    HELIX   93 AK3 ILE C  199  ASN C  205  1                                   7    
    HELIX   94 AK4 THR C  217  ARG C  225  1                                   9    
    HELIX   95 AK5 GLY C  228  ALA C  239  1                                  12    
    HELIX   96 AK6 THR C  264  THR C  272  1                                   9    
    HELIX   97 AK7 PRO C  275  HIS C  284  1                                  10    
    HELIX   98 AK8 ASN C  298  THR C  305  1                                   8    
    HELIX   99 AK9 ASP C  315  SER C  328  1                                  14    
    HELIX  100 AL1 THR C  343  MET C  351  1                                   9    
    HELIX  101 AL2 ALA C  354  SER C  362  1                                   9    
    HELIX  102 AL3 GLU C  367  SER C  374  1                                   8    
    HELIX  103 AL4 SER C  402  TYR C  409  1                                   8    
    HELIX  104 AL5 ASN C  415  THR C  421  1                                   7    
    HELIX  105 AL6 LEU C  422  TYR C  461  1                                  40    
    HELIX  106 AL7 TRP C  481  LEU C  507  1                                  27    
    HELIX  107 AL8 ALA C  520  PHE C  542  1                                  23    
    HELIX  108 AL9 GLU C  546  ASN C  561  1                                  16    
    HELIX  109 AM1 MET C  562  GLY C  568  5                                   7    
    HELIX  110 AM2 PHE C  569  ASP C  586  1                                  18    
    HELIX  111 AM3 ASP C  586  ILE C  609  1                                  24    
    HELIX  112 AM4 SER C  624  GLY C  638  1                                  15    
    HELIX  113 AM5 TYR C  650  THR C  680  1                                  31    
    HELIX  114 AM6 ASN C  683  LEU C  707  1                                  25    
    HELIX  115 AM7 PRO C  708  ARG C  716  1                                   9    
    HELIX  116 AM8 LYS C  738  ASN C  750  1                                  13    
    SHEET    1 AA1 4 PHE A 377  TYR A 382  0                                        
    SHEET    2 AA1 4 VAL A 385  ASP A 391 -1  O  LEU A 389   N  PHE A 377           
    SHEET    3 AA1 4 LEU A 730  GLU A 736 -1  O  ILE A 734   N  SER A 388           
    SHEET    4 AA1 4 GLU A 719  LEU A 720 -1  N  GLU A 719   O  CYS A 731           
    SHEET    1 AA2 4 PHE B 377  TYR B 382  0                                        
    SHEET    2 AA2 4 VAL B 385  ASP B 391 -1  O  LEU B 389   N  PHE B 377           
    SHEET    3 AA2 4 LEU B 730  GLU B 736 -1  O  GLU B 736   N  SER B 386           
    SHEET    4 AA2 4 GLU B 719  LEU B 720 -1  N  GLU B 719   O  CYS B 731           
    SHEET    1 AA3 4 PHE D 377  TYR D 382  0                                        
    SHEET    2 AA3 4 VAL D 385  ASP D 391 -1  O  LEU D 389   N  PHE D 377           
    SHEET    3 AA3 4 LEU D 730  GLU D 736 -1  O  GLU D 736   N  SER D 386           
    SHEET    4 AA3 4 GLU D 719  LEU D 720 -1  N  GLU D 719   O  CYS D 731           
    SHEET    1 AA4 4 PHE C 377  TYR C 382  0                                        
    SHEET    2 AA4 4 VAL C 385  ASP C 391 -1  O  LEU C 389   N  PHE C 377           
    SHEET    3 AA4 4 LEU C 730  GLU C 736 -1  O  GLU C 736   N  SER C 386           
    SHEET    4 AA4 4 GLU C 719  LEU C 720 -1  N  GLU C 719   O  CYS C 731           
    CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
    ORIGX1      1.000000  0.000000  0.000000        0.00000                         
    ORIGX2      0.000000  1.000000  0.000000        0.00000                         
    ORIGX3      0.000000  0.000000  1.000000        0.00000                         
    SCALE1      0.003617  0.000000  0.000000        0.00000                         
    SCALE2      0.000000  0.003617  0.000000        0.00000                         
    SCALE3      0.000000  0.000000  0.003617        0.00000                         

    3D molecular view of vibration

    Displacement vectors
    Display
    Animation
    Display

    Still image of displacement vectors and GIF animation


    Mode 1

    Time-average properties and properties of the 10 lowest-frequency modes

    Fluctuation of atoms:
    Time average and for the 3 lowest-frequency modes.
    Fluctuation of dihedral angles:
    Time average and for the 3 lowest-frequency modes.
    Fluctuation of atomsFluctuation of dihedral angles

    Correlations between fluctuations of atoms

    Mode 1
    Correlations between fluctuations of atoms - Mode 1
    Time Average
    Time Average
    Distance map
    Distance map

    Calculation note

    PDB file name : pdb6ot2.ent

    Chains and HETATMs selected: 
      ATOM        A

    The following atoms are removed from PDB data on concern that they may have 
    abnormally large fluctuations, because they interact with few atoms.
      ATOM   2456  CG  LYS A 318     143.793 160.868 106.400  1.00 66.37           C  
      ATOM   2457  CD  LYS A 318     144.051 159.428 106.806  1.00 66.37           C  
      ATOM   2458  CE  LYS A 318     145.540 159.126 106.823  1.00 66.37           C  
      ATOM   2459  NZ  LYS A 318     145.824 157.719 107.215  1.00 66.37           N  
      ATOM   2478  CG  ARG A 319     142.124 160.640 101.244  1.00 71.29           C  
      ATOM   2479  CD  ARG A 319     141.581 159.806 100.095  1.00 71.29           C  
      ATOM   2480  NE  ARG A 319     140.246 159.282 100.367  1.00 71.29           N  
      ATOM   2481  CZ  ARG A 319     139.121 159.838  99.929  1.00 71.29           C  
      ATOM   2482  NH1 ARG A 319     139.166 160.941  99.196  1.00 71.29           N  
      ATOM   2483  NH2 ARG A 319     137.951 159.289 100.225  1.00 71.29           N  
      ATOM   7524  CG  LYS A 705     155.038 174.023 136.134  1.00 79.36           C  
      ATOM   8054  CG  LYS A 743     160.331 140.175 108.170  1.00 71.40           C  
      ATOM   8055  CD  LYS A 743     160.667 139.215 109.277  1.00 71.40           C  
      ATOM   8056  CE  LYS A 743     160.798 137.809 108.732  1.00 71.40           C  
      ATOM   8057  NZ  LYS A 743     161.153 136.810 109.767  1.00 71.40           N  

    = Normal mode analysis calculation =

    No. of modes used in the calculation : All modes.

    Parameters of potential energies:
      1-4 and 1-5 non-bonded interactions: E(d) = A*exp(-d(PDB)**2/B**2)(d-d(PDB))**2.
      Loop-closing potential:              E(d) = A*(d-d(PDB))**2.
        for a disulfide bond and one of the bonds in the DNA and RNA sugar ring.
      where d and d(PDB) are distances between atoms in calculation and in PDB data, 
      respectively.

      Interaction type   A       B      Cutoff distance (A)
        1-4             1.00    5.00      100.00
        1-5             1.00    5.00      100.00
        Loop-closing  100.00

    Temperature adjustment by magnitude of fluctuation:
      Set to mean displacements of atoms       0.500 A

    Animation
      No. of frames: 11
      Mean displacements (A):    0.50

    Displacement vector
      Mean length of vectors (A):    3.00