9SFM

Crystal structure of Cereblon-DDB1 in complex with SB-405483 and Lenalidomide

This is a non-PDB format compatible entry.

Summary for 9SFM

• Entry DOI: 10.2210/pdb9sfm/pdb
• Descriptor: DNA damage-binding protein 1, Protein cereblon, 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: e3 ubiquitin ligase, substrate receptor, imids (immunomodulatory drugs), allosteric modulator, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 173175.64

Authors

Chung, C. (deposition date: 2025-08-19, release date: 2025-11-19)

• Primary citation: Chung, C.; : Identification of an allosteric site on the E3 ligase adapter cereblon.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.39 Å)