9MCX

CRYSTAL STRUCTURE OF HUMAN IGG1 FC FRAGMENT-FC-GAMMA RECEPTOR IIA COMPLEX H131 VARIANT

Summary for 9MCX

Entry DOI	10.2210/pdb9mcx/pdb
Descriptor	Immunoglobulin gamma-1 heavy chain Fc fragment, Low affinity immunoglobulin gamma Fc region receptor II-a H131 variant, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	immunoglobulin, igg1, immune system, immunoglobulin-like beta sandwich, fc fragment, fc gamma receptor iia, cd32a
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	73486.13
Authors	Tolbert, W.D.,Pazgier, M. (deposition date: 2024-12-05, release date: 2025-12-03)
Primary citation	Tolbert, W.D.,Nhan, P.B.,Conley, H.E.,Ge, X.,Chandravanshi, M.,Lee, M.,Veilleux, J.,Korzeniowski, M.,Gottumukkala, S.,Ackerman, M.E.,Pollara, J.,Pazgier, M. Cross-species analysis of FcgRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in human and macaque. Front Immunol, 2025 Cited by DOI: 10.3389/fimmu.2025.1726068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.38 Å)

Structure validation