9HM2

A swapped dimeric form of ZO1/TJP1 PDZ2 in complex with the C-terminal peptide from protein E of SARS-CoV-2

Summary for 9HM2

Entry DOI	10.2210/pdb9hm2/pdb
Descriptor	Tight junction protein ZO-1, Envelope small membrane protein, IODIDE ION, ... (4 entities in total)
Functional Keywords	pdz2, scaffolding, cell adhesion, tight junction
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	21986.85
Authors	Alvarez, F.,Mechaly, A.,Haouz, A.,Caillet-Saguy, C. (deposition date: 2024-12-06, release date: 2025-10-22)
Primary citation	Alvarez, F.,Larrous, F.,Mechaly, A.,Bardiaux, B.,Goor, Q.,Haouz, A.,Seon-Meniel, B.,De Sousa, R.A.,Bourg, S.,Figadere, B.,Wolff, N.,Munier-Lehmann, H.,Caillet-Saguy, C. HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2 Biorxiv, 2025 Cited by DOI: 10.1101/2025.07.16.665136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation