9H1J

Crystal structure of the p62 UBA domain bound to VHH 6C10

Summary for 9H1J

Entry DOI	10.2210/pdb9h1j/pdb
Descriptor	VHH 6C10, Sequestosome-1 (3 entities in total)
Functional Keywords	autophagy, macroautophagy, ubiquitin binding proteins, protein transport
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	75728.13
Authors	Gutmann, S.,Villard, F. (deposition date: 2024-10-09, release date: 2025-10-29)
Primary citation	Thiel, Z.,Marcellin, D.,Manneville, C.,Goretzki, B.,Egger, L.,Maher, R.,Siccardi, N.,Sandig, G.,Torres, L.,Probst, A.,Mueller, C.S.,George, N.,Vogel, M.,Lavoisier, A.,Choi, J.Y.,Forcellino, L.,Hauck, P.,Be, C.,Villard, F.,Gutmann, S.,Meyer, M.,Freuler, F.,Patoor, M.,Mitchell, G.,Nyfeler, B. Development of a p62 biodegrader for autophagy targeted degradation To Be Published,
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation