9H02

Crystal structure of human CREBBP histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA

Summary for 9H02

• Entry DOI: 10.2210/pdb9h02/pdb
• Descriptor: CREB-binding protein, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: histone acetyltransferase, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 41853.19

Authors

Mechaly, A.E.,Cui, G.,Green, M.R.,Rodrigues-Lima, F. (deposition date: 2024-10-07, release date: 2025-10-15)

• Primary citation: Mechaly, A.E.,Cui, G.,Green, M.R.,Rodrigues-Lima, F.; Crystal structure of human CREBBP histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.03 Å)