9EPU

Crystal structure of the human CDKL5 kinase domain with compound CAF-382

This is a non-PDB format compatible entry.

Summary for 9EPU

• Entry DOI: 10.2210/pdb9epu/pdb
• Descriptor: Cyclin-dependent kinase-like 5, ~{N}-[5-[(5-propan-2-yl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide, SULFATE ION, ... (6 entities in total)
• Functional Keywords: kinase, gene regulation
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35988.55

Authors

Richardson, W.,Chen, X.,Newman, J.A.,Bakshi, S.,Lakshminarayana, B.,Brooke, L.,Bullock, A.N. (deposition date: 2024-03-20, release date: 2025-04-02)

• Primary citation: Capener, J.L.,Kim, J.K.,Richardson, W.,Silvaroli, J.A.,Martinez, G.V.,Thorson, V.C.,Li, J.,Hoyt, K.R.,Satoskar, A.A.,Mallipattu, S.K.,Davidson, A.J.,Zepeda-Orozco, D.,Bajwa, A.,Bullock, A.N.,Axtman, A.D.,Pabla, N.S.; Crystal structure of the human CDKL5 kinase domain with compound CAF-382; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)