9DK5

Cryo-EM structure of human Nav1.6 in complex with PaurTx3

Summary for 9DK5

• Entry DOI: 10.2210/pdb9dk5/pdb
• EMDB information: 46943
• Descriptor: Sodium channel protein type 8 subunit alpha, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (14 entities in total)
• Functional Keywords: nav1.6, voltage gated sodium channel, cryo-em, toxin, paurtx3, transport protein-toxin complex, transport protein/toxin
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 273508.24

Authors

Fan, X.,Huang, J.,Yan, N. (deposition date: 2024-09-08, release date: 2025-09-17)

• Primary citation: Fan, X.,Jian, H.,Chen, J.,Wang, H.,Wu, Q.,Liu, T.,Guo, Q.,Shen, Z.,Pan, X.,Jin, X.,Yan, N.; Diverse modulation mechanisms of human Nav1.6 by gating modifier neurotoxins; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.9 Å)