9EY7
Crystal structure of human tyrosinase-related protein 1 (TYRP1) in complex with (R)-2,4-dihydroxyphenylalanine
Summary for 9EY7
Entry DOI | 10.2210/pdb9ey7/pdb |
Descriptor | 5,6-dihydroxyindole-2-carboxylic acid oxidase, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | melanogenesis, human tyrosinase, tyrosinase inhibitor, metal binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 54225.07 |
Authors | Ng, Y.M.,Soler-Lopez, M. (deposition date: 2024-04-09, release date: 2024-05-22, Last modification date: 2024-07-03) |
Primary citation | Faure, C.,Min Ng, Y.,Belle, C.,Soler-Lopez, M.,Khettabi, L.,Saidi, M.,Berthet, N.,Maresca, M.,Philouze, C.,Rachidi, W.,Reglier, M.,du Moulinet d'Hardemare, A.,Jamet, H. Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies. Chembiochem, 25:e202400235-e202400235, 2024 Cited by PubMed: 38642076DOI: 10.1002/cbic.202400235 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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