9AVG
Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs
This is a non-PDB format compatible entry.
Summary for 9AVG
Entry DOI | 10.2210/pdb9avg/pdb |
EMDB information | 43901 |
Descriptor | Isoform 1 of Extracellular calcium-sensing receptor, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, CHOLESTEROL HEMISUCCINATE, ... (12 entities in total) |
Functional Keywords | calcium-sensing receptor, g-protein-coupled receptor, g protein, signal transduction, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 285944.48 |
Authors | Zuo, H.,Park, J.,Frangaj, A.,Ye, J.,Lu, G.,Manning, J.J.,Asher, W.B.,Lu, Z.,Hu, G.,Wang, L.,Mendez, J.,Eng, E.,Zhang, Z.,Lin, X.,Grasucci, R.,Hendrickson, W.A.,Clarke, O.B.,Javitch, J.A.,Conigrave, A.D.,Fan, Q.R. (deposition date: 2024-03-02, release date: 2024-04-17, Last modification date: 2024-05-22) |
Primary citation | Zuo, H.,Park, J.,Frangaj, A.,Ye, J.,Lu, G.,Manning, J.J.,Asher, W.B.,Lu, Z.,Hu, G.B.,Wang, L.,Mendez, J.,Eng, E.,Zhang, Z.,Lin, X.,Grassucci, R.,Hendrickson, W.A.,Clarke, O.B.,Javitch, J.A.,Conigrave, A.D.,Fan, Q.R. Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629:481-488, 2024 Cited by PubMed: 38632411DOI: 10.1038/s41586-024-07331-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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