8VPH

CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Containing Quinoline-based SGI-1027 Analog 455 and Inhibitor MC4741

This is a non-PDB format compatible entry.

Summary for 8VPH

• Entry DOI: 10.2210/pdb8vph/pdb
• Descriptor: Site-specific DNA-methyltransferase (adenine-specific), DNA Strand II, DNA Strand I, ... (6 entities in total)
• Functional Keywords: dna adenine methylation, protein-dna complex, transferase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Clostridioides difficile; More
• Total number of polymer chains: 9
• Total formula weight: 233597.79

Authors

Zhou, J.,Horton, J.R.,Cheng, X. (deposition date: 2024-01-16, release date: 2024-09-25)

• Primary citation: Zhou, J.,Chen, Q.,Ren, R.,Yang, J.,Chang, C.,Liu, B.,Horton, J.R.,Li, C.,Maksoud, L.,Yang, Y.,Rotili, D.,Jain, A.K.,Zhang, X.,Blumenthal, R.M.,Chen, T.,Gao, Y.,Valente, S.,Mai, A.,Cheng, X.; Quinoline-based compounds can inhibit diverse enzymes that act on DNA; Cell Chem Biol, 2024

Experimental method

X-RAY DIFFRACTION (3.18 Å)