8SIA

Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor NS8593 in closed state

8SIA の概要

• エントリーDOI: 10.2210/pdb8sia/pdb
• 関連するPDBエントリー: 8SI2 8SI3 8SI4 8SI5 8SI6 8SI7 8SI8
• EMDBエントリー: 40496 40497 40498 40499 40500 40501 40502 40504
• 分子名称: Transient receptor potential cation channel subfamily M member 7, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... (6 entities in total)
• 機能のキーワード: transient receptor potential m family member 7, trp, channel, trpm7, trp channels, membrane protein, magnesium channel, inhibitor, ligand, ns8593
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 631842.57

構造登録者

Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (登録日: 2023-04-14, 公開日: 2023-05-17, 最終更新日: 2023-05-24)

• 主引用文献: Nadezhdin, K.D.,Correia, L.,Narangoda, C.,Patel, D.S.,Neuberger, A.,Gudermann, T.,Kurnikova, M.G.,Chubanov, V.,Sobolevsky, A.I.; Structural mechanisms of TRPM7 activation and inhibition.; Nat Commun, 14:2639-2639, 2023; PubMed: 37156763; DOI: 10.1038/s41467-023-38362-3

実験手法

ELECTRON MICROSCOPY (2.91 Å)