8KB4

Cryo-EM structure of human TMEM87A A308M

Summary for 8KB4

• Entry DOI: 10.2210/pdb8kb4/pdb
• Related: 8HSI 8HTT
• EMDB information: 37069
• Descriptor: Transmembrane protein 87A,EGFP, 2-acetamido-2-deoxy-beta-D-glucopyranose, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate (3 entities in total)
• Functional Keywords: non-selective cation channel, ion channel, membrane protein, golgi-localized protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 98128.72

Authors

Han, A.,Kim, H.M. (deposition date: 2023-08-03, release date: 2024-07-10, Last modification date: 2024-09-18)

• Primary citation: Kang, H.,Han, A.R.,Zhang, A.,Jeong, H.,Koh, W.,Lee, J.M.,Lee, H.,Jo, H.Y.,Maria-Solano, M.A.,Bhalla, M.,Kwon, J.,Roh, W.S.,Yang, J.,An, H.J.,Choi, S.,Kim, H.M.,Lee, C.J.; GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory.; Nat Commun, 15:5830-5830, 2024; PubMed: 38992057; DOI: 10.1038/s41467-024-49297-8

Experimental method

ELECTRON MICROSCOPY (3.1 Å)