8I5N

Rat Kir4.1 in complex with PIP2 and Lys05

Summary for 8I5N

• Entry DOI: 10.2210/pdb8i5n/pdb
• EMDB information: 35196
• Descriptor: ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (2 entities in total)
• Functional Keywords: kir4.1, ion channel, transport protein, membrane protein
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 4
• Total formula weight: 158153.16

Authors

Zhao, C.,Guo, J. (deposition date: 2023-01-26, release date: 2024-02-28, Last modification date: 2024-09-11)

• Primary citation: Zhou, X.,Zhao, C.,Xu, H.,Xu, Y.,Zhan, L.,Wang, P.,He, J.,Lu, T.,Gu, Y.,Yang, Y.,Xu, C.,Chen, Y.,Liu, Y.,Zeng, Y.,Tian, F.,Chen, Q.,Xie, X.,Liu, J.,Hu, H.,Li, J.,Zheng, Y.,Guo, J.,Gao, Z.; Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses.; Nat.Chem.Biol., 20:857-866, 2024; PubMed: 38355723; DOI: 10.1038/s41589-024-01555-y

Experimental method

ELECTRON MICROSCOPY (2.85 Å)