8HVP

STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR

8HVP の概要

• エントリーDOI: 10.2210/pdb8hvp/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000362
• 分子名称: HIV-1 PROTEASE, INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL (U-85548E) (3 entities in total)
• 機能のキーワード: acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 22401.33

構造登録者

Jaskolski, M.,Miller, M.,Tomasselli, A.G.,Sawyer, T.K.,Staples, D.G.,Heinrikson, R.L.,Schneider, J.,Kent, S.B.H.,Wlodawer, A. (登録日: 1990-10-26, 公開日: 1993-10-31, 最終更新日: 2023-11-15)

• 主引用文献: Jaskolski, M.,Tomasselli, A.G.,Sawyer, T.K.,Staples, D.G.,Heinrikson, R.L.,Schneider, J.,Kent, S.B.,Wlodawer, A.; Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor.; Biochemistry, 30:1600-1609, 1991; PubMed: 1993177; DOI: 10.1021/bi00220a023

実験手法

X-RAY DIFFRACTION (2.5 Å)