8HMU

Crystal Structure of PKM2 mutant R516C

Summary for 8HMU

• Entry DOI: 10.2210/pdb8hmu/pdb
• Descriptor: Pyruvate kinase PKM, 1,6-di-O-phosphono-beta-D-fructofuranose, OXALATE ION, ... (8 entities in total)
• Functional Keywords: pkm2, hydroxylation, kinase, glycolysis, tumour promoting, warburg effect, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 244415.96

Authors

Upadhyay, S.,Kumar, A.,Patel, A.K. (deposition date: 2022-12-05, release date: 2023-01-11, Last modification date: 2024-05-29)

• Primary citation: Upadhyay, S.,Kumar, A.,Patel, A.K.; Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)