8G46
Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2
Summary for 8G46
Entry DOI | 10.2210/pdb8g46/pdb |
EMDB information | 29714 |
Descriptor | DNA damage-binding protein 1, DDB1- and CUL4-associated factor 16, Bromodomain-containing protein 4, ... (7 entities in total) |
Functional Keywords | e3 ligase, ubiquitin, degrader, targeted protein degradation, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 148651.12 |
Authors | Ma, M.W.,Hunkeler, M.,Jin, C.Y.,Fischer, E.S. (deposition date: 2023-02-08, release date: 2023-03-08) |
Primary citation | Li, Y.D.,Ma, M.W.,Hassan, M.M.,Hunkeler, M.,Teng, M.,Puvar, K.,Lumpkin, R.,Sandoval, B.,Jin, C.Y.,Ficarro, S.B.,Wang, M.Y.,Xu, S.,Groendyke, B.J.,Sigua, L.H.,Tavares, I.,Zou, C.,Tsai, J.M.,Park, P.M.C.,Yoon, H.,Majewski, F.C.,Marto, J.A.,Qi, J.,Nowak, R.P.,Donovan, K.A.,Slabicki, M.,Gray, N.S.,Fischer, E.S.,Ebert, B.L. Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. Biorxiv, 2023 Cited by PubMed: 36824856DOI: 10.1101/2023.02.14.528208 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.2 Å) |
Structure validation
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