8XX0

Crystal structure of anti-IgE antibody HMK-12 Fab complexed with IgE F(ab')2

Summary for 8XX0

Entry DOI	10.2210/pdb8xx0/pdb
Descriptor	anti-IgE antibody HMK-12 Fab light chain, anti-IgE antibody HMK-12 Fab heavy chain, SPE7 immunoglobulin E F(ab')2 heavy chain, ... (8 entities in total)
Functional Keywords	allergy, allosteric, immune system
Biological source	Rattus norvegicus (rat) More
Total number of polymer chains	4
Total formula weight	108240.82
Authors	Hirano, T.,Koyanagi, A.,Kasai, M.,Okumura, K. (deposition date: 2024-01-17, release date: 2024-07-31, Last modification date: 2024-09-04)
Primary citation	Hirano, T.,Koyanagi, A.,Ago, H.,Yamamoto, M.,Kitaura, J.,Kasai, M.,Okumura, K. Allosteric inhibition of IgE-Fc epsilon RI interactions by simultaneous targeting of IgE F(ab')2 epitopes. Commun Biol, 7:1042-1042, 2024 Cited by PubMed: 39179708 DOI: 10.1038/s42003-024-06633-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation