8VIW

Cryo-EM structure of heparosan synthase 2 from Pasteurella multocida with polysaccharide in the GlcNAc-T active site

Summary for 8VIW

• Entry DOI: 10.2210/pdb8viw/pdb
• Related: 8VH7 8VH8
• EMDB information: 43269
• Descriptor: Heparosan synthase B, beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: polysaccharide synthase, complex, transferase
• Biological source: Pasteurella multocida
• Total number of polymer chains: 4
• Total formula weight: 265981.20

Authors

Krahn, J.M.,Pedersen, L.C.,Liu, J.,Stancanelli, E.,Borgnia, M.,Vivarette, E. (deposition date: 2024-01-05, release date: 2024-07-24)

• Primary citation: Stancanelli, E.,Krahn, J.A.,Viverette, E.,Dutcher, R.,Pagadala, V.,Borgnia, M.J.,Liu, J.,Pedersen, L.C.; Structural and Functional Analysis of Heparosan Synthase 2 from Pasteurella multocida to Improve the Synthesis of Heparin; Acs Catalysis, 14:6577-6588, 2024; DOI: 10.1021/acscatal.4c00677

Experimental method

ELECTRON MICROSCOPY (3.3 Å)