8TNI
Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex
Summary for 8TNI
Entry DOI | 10.2210/pdb8tni/pdb |
EMDB information | 41415 41416 41417 |
Descriptor | HIV-1 BG505 DS-SOSIP gp120, HIV-1 BG505 DS-SOSIP gp41, Light chain of bi-specific antibody CAP256L-R27, ... (8 entities in total) |
Functional Keywords | hiv-1 envelope, bi-specific, antibody, nanobody, vhh, llama, bg505 ds-sosip, neutralization, cap256, r27, immunization, viral protein-immune system complex, viral protein/immune system |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 10 |
Total formula weight | 366676.98 |
Authors | Zhou, T.,Morano, N.C.,Roark, R.S.,Kwong, P.D.,Xu, J. (deposition date: 2023-08-01, release date: 2024-05-08) |
Primary citation | Xu, J.,Zhou, T. Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex To Be Published, |
Experimental method | ELECTRON MICROSCOPY (3.61 Å) |
Structure validation
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