8SO3
CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3
Summary for 8SO3
Entry DOI | 10.2210/pdb8so3/pdb |
EMDB information | 40646 |
Descriptor | Lymphocyte activation gene 3 protein, favezelimab Fab heavy chain, favezelimab Fab light chain, ... (4 entities in total) |
Functional Keywords | lymphocyte activation gene 3 protein, favezelimab-lag3 complex, cryoem, single particle reconstruction., immunosuppressant |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 222224.08 |
Authors | Mishra, A.K.,Shahid, S.,Karade, S.S.,Mariuzza, R.A. (deposition date: 2023-04-28, release date: 2023-09-06, Last modification date: 2023-10-18) |
Primary citation | Mishra, A.K.,Shahid, S.,Karade, S.S.,Agnihotri, P.,Kolesnikov, A.,Hasan, S.S.,Mariuzza, R.A. CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker. Structure, 31:1149-, 2023 Cited by PubMed: 37619561DOI: 10.1016/j.str.2023.07.013 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.61 Å) |
Structure validation
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