8SI9
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone
Summary for 8SI9
Entry DOI | 10.2210/pdb8si9/pdb |
EMDB information | 40503 40506 |
Descriptor | Gamma-aminobutyric acid receptor subunit beta-2, allopregnanolone, GAMMA-AMINO-BUTANOIC ACID, ... (11 entities in total) |
Functional Keywords | ion channel, neurosteroids, transport protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 9 |
Total formula weight | 365240.87 |
Authors | Legesse, D.H.,Hibbs, R.E. (deposition date: 2023-04-14, release date: 2023-08-30, Last modification date: 2023-11-15) |
Primary citation | Legesse, D.H.,Fan, C.,Teng, J.,Zhuang, Y.,Howard, R.J.,Noviello, C.M.,Lindahl, E.,Hibbs, R.E. Structural insights into opposing actions of neurosteroids on GABA A receptors. Nat Commun, 14:5091-5091, 2023 Cited by PubMed: 37607940DOI: 10.1038/s41467-023-40800-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.98 Å) |
Structure validation
Download full validation report