8QY4

Structure of interleukin 11 (gp130 P496L mutant).

Summary for 8QY4

Entry DOI	10.2210/pdb8qy4/pdb
EMDB information	18741
Descriptor	Interleukin-11, Interleukin-6 receptor subunit beta, Interleukin-11 receptor subunit alpha, ... (5 entities in total)
Functional Keywords	interleukin, gp130, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	343338.98
Authors	Gardner, S.,Bubeck, D.,Jin, Y. (deposition date: 2023-10-25, release date: 2024-02-21, Last modification date: 2024-09-04)
Primary citation	Gardner, S.,Jin, Y.,Fyfe, P.K.,Voisin, T.B.,Bellon, J.S.,Pohler, E.,Piehler, J.,Moraga, I.,Bubeck, D. Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nat Commun, 15:2071-2071, 2024 Cited by PubMed: 38453915 DOI: 10.1038/s41467-024-46235-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.06 Å)

Structure validation