8OQZ
Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in complex with Ab46
Summary for 8OQZ
Entry DOI | 10.2210/pdb8oqz/pdb |
EMDB information | 17113 |
Descriptor | Nicastrin, Presenilin-1 CTF12, Gamma-secretase subunit APH-1B, ... (8 entities in total) |
Functional Keywords | intramembrane proteolysis, protease, di-aspartyl protease, alzheimer's disease, complex, amyloid beta, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 192299.82 |
Authors | Odorcic, I.,Chavez Gutierrez, L.,Efremov, R.G. (deposition date: 2023-04-12, release date: 2024-04-24, Last modification date: 2024-06-19) |
Primary citation | Odorcic, I.,Hamed, M.B.,Lismont, S.,Chavez-Gutierrez, L.,Efremov, R.G. Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform. Nat Commun, 15:4479-4479, 2024 Cited by PubMed: 38802343DOI: 10.1038/s41467-024-48776-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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