8KCO
Cryo-EM structure of human gamma-secretase in complex with RO4929097
Summary for 8KCO
Entry DOI | 10.2210/pdb8kco/pdb |
EMDB information | 37106 |
Descriptor | Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total) |
Functional Keywords | intramembrane protease, gamma-secretase, gamma-secretase inhibitor, membrane protein, membrane protein-hydrolase complex |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 178961.86 |
Authors | |
Primary citation | Guo, X.,Wang, Y.,Zhou, J.,Jin, C.,Wang, J.,Jia, B.,Jing, D.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y. CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 To Be Published, |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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