8K8E
Human gamma-secretase in complex with a substrate mimetic
Summary for 8K8E
Entry DOI | 10.2210/pdb8k8e/pdb |
EMDB information | 36948 |
Descriptor | Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total) |
Functional Keywords | complex, protease, substrate mimetic, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 178324.58 |
Authors | Shi, Y.G.,Zhou, R.,Wolfe, M.S. (deposition date: 2023-07-29, release date: 2024-01-31, Last modification date: 2024-02-28) |
Primary citation | Devkota, S.,Zhou, R.,Nagarajan, V.,Maesako, M.,Do, H.,Noorani, A.,Overmeyer, C.,Bhattarai, S.,Douglas, J.T.,Saraf, A.,Miao, Y.,Ackley, B.D.,Shi, Y.,Wolfe, M.S. Familial Alzheimer mutations stabilize synaptotoxic gamma-secretase-substrate complexes. Cell Rep, 43:113761-113761, 2024 Cited by PubMed: 38349793DOI: 10.1016/j.celrep.2024.113761 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
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