8J75

Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, monomeric state

Summary for 8J75

• Entry DOI: 10.2210/pdb8j75/pdb
• EMDB information: 36027
• Descriptor: High affinity choline transporter 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium) (3 entities in total)
• Functional Keywords: cht1, slc5a7, high affinity choline transporter, choline transporter, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 64240.22

Authors

Gao, Y.,Qiu, Y.,Zhao, Y. (deposition date: 2023-04-27, release date: 2024-04-10, Last modification date: 2024-05-01)

• Primary citation: Qiu, Y.,Gao, Y.,Huang, B.,Bai, Q.,Zhao, Y.; Transport mechanism of presynaptic high-affinity choline uptake by CHT1.; Nat.Struct.Mol.Biol., 31:701-709, 2024; PubMed: 38589607; DOI: 10.1038/s41594-024-01259-w

Experimental method

ELECTRON MICROSCOPY (3.6 Å)