8IM7
Human gamma-secretase treated with ganglioside GM1
Summary for 8IM7
Entry DOI | 10.2210/pdb8im7/pdb |
EMDB information | 35572 |
Descriptor | Nicastrin, Presenilin-1 CTF12, Gamma-secretase subunit APH-1A, ... (9 entities in total) |
Functional Keywords | intramembrane protease, lipid, ganglioside, gm1, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 178966.75 |
Authors | |
Primary citation | Wang, X.,Zhou, R.,Sun, X.,Li, J.,Wang, J.,Yue, W.,Wang, L.,Liu, H.,Shi, Y.,Zhang, D. Preferential Regulation of Gamma-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease. Adv Sci, 10:e2303411-e2303411, 2023 Cited by PubMed: 37759382DOI: 10.1002/advs.202303411 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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