8HNH
Cryo-EM structure of human OATP1B1 in complex with simeprevir
Summary for 8HNH
Entry DOI | 10.2210/pdb8hnh/pdb |
EMDB information | 34913 |
Descriptor | Solute carrier organic anion transporter family member 1B1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-({7-methoxy-8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, ... (4 entities in total) |
Functional Keywords | transporter, oatp1b1, organic anion transporting peptide, membrane protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 81725.86 |
Authors | |
Primary citation | Shan, Z.,Yang, X.,Liu, H.,Yuan, Y.,Xiao, Y.,Nan, J.,Zhang, W.,Song, W.,Wang, J.,Wei, F.,Zhang, Y. Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33:940-951, 2023 Cited by PubMed: 37674011DOI: 10.1038/s41422-023-00870-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.73 Å) |
Structure validation
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