8EPA
Structure of interleukin receptor common gamma chain (IL2Rgamma) in complex with two antibodies
Summary for 8EPA
Entry DOI | 10.2210/pdb8epa/pdb |
EMDB information | 28523 |
Descriptor | Cytokine receptor common subunit gamma, REGN7257 Fab heavy chain, REGN7257 Fab light chain, ... (6 entities in total) |
Functional Keywords | interleukin signaling, lymphocyte maturation, blocking antibody, immunoglobulin, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 125760.90 |
Authors | |
Primary citation | Le Floc'h, A.,Nagashima, K.,Birchard, D.,Scott, G.,Ben, L.H.,Ajithdoss, D.,Gayvert, K.,Romero Hernandez, A.,Herbin, O.,Tay, A.,Farrales, P.,Korgaonkar, C.K.,Pan, H.,Shah, S.,Kamat, V.,Chatterjee, I.,Popke, J.,Oyejide, A.,Lim, W.K.,Kim, J.H.,Huang, T.,Franklin, M.,Olson, W.,Norton, T.,Perlee, L.,Yancopoulos, G.D.,Murphy, A.J.,Sleeman, M.A.,Orengo, J.M. Blocking common gamma chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models. Sci Transl Med, 15:eabo0205-eabo0205, 2023 Cited by PubMed: 36630481DOI: 10.1126/scitranslmed.abo0205 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
Download full validation report