8EOK
Structure of the C3bB proconvertase in complex with lufaxin and factor Xa
Summary for 8EOK
Entry DOI | 10.2210/pdb8eok/pdb |
EMDB information | 28378 |
Descriptor | Complement C3 beta chain, Complement C3b alpha' chain, Complement factor B, ... (9 entities in total) |
Functional Keywords | complement, alternative pathway, inhibitor, sand fly, immune system |
Biological source | Lutzomyia longipalpis More |
Total number of polymer chains | 6 |
Total formula weight | 339146.34 |
Authors | |
Primary citation | Andersen, J.F.,Lei, H.,Strayer, E.C.,Kanai, T.,Pham, V.,Pan, X.Z.,Alvarenga, P.H.,Gerber, G.F.,Asojo, O.A.,Francischetti, I.M.B.,Brodsky, R.A.,Valenzuela, J.G.,Ribeiro, J.M.C. A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141:3109-3121, 2023 Cited by PubMed: 36947859DOI: 10.1182/blood.2022019359 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.53 Å) |
Structure validation
Download full validation report