8DPU
The crystal structure of the IL-11 signalling complex
Summary for 8DPU
Entry DOI | 10.2210/pdb8dpu/pdb |
Descriptor | Interleukin-6 receptor subunit beta, Interleukin-11, Interleukin-11 receptor subunit alpha, ... (6 entities in total) |
Functional Keywords | complex, gp130, glycoprotein 130, signalling, cancer, cytokine, cytokine-receptor complex |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 18 |
Total formula weight | 561230.71 |
Authors | Metcalfe, R.D.,Aizel, K.,Griffin, M.D.W. (deposition date: 2022-07-17, release date: 2023-11-29, Last modification date: 2024-05-01) |
Primary citation | Metcalfe, R.D.,Hanssen, E.,Fung, K.Y.,Aizel, K.,Kosasih, C.C.,Zlatic, C.O.,Doughty, L.,Morton, C.J.,Leis, A.P.,Parker, M.W.,Gooley, P.R.,Putoczki, T.L.,Griffin, M.D.W. Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14:7543-7543, 2023 Cited by PubMed: 37985757DOI: 10.1038/s41467-023-42754-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.78 Å) |
Structure validation
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